Surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)uses inorganic nanomaterials as matrixes to facilitate desorption and ionization of analytes.Compared with the traditional matrix-assisted laser ...Surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)uses inorganic nanomaterials as matrixes to facilitate desorption and ionization of analytes.Compared with the traditional matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)technique,SALDI-MS has the advantages of less interference in the low mass range,better reproducibility and higher salt tolerance.It is highly suitable for the analysis of small molecule compounds.In recent years,researchers have developed a range of nanomaterials that are successfully applied to the field of small molecule drug and metabolite analysis including drug screening and quantification,drug delivery,metabolite profiling,biomarker discovery and so forth.This review summarizes the latest progress of SALDI-MS matrix materials such as metal-based,carbon-based,silica-based nanomaterials and organic framework nanomaterials and their applications.In addition,our perspective of SALDI-MS technology is also discussed for further advancement.展开更多
基金State Key Laboratory of Natural and Biomimetic Drugs(Peking University)the National Natural Science Foundation of China(Grant No.21804123)。
文摘Surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)uses inorganic nanomaterials as matrixes to facilitate desorption and ionization of analytes.Compared with the traditional matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)technique,SALDI-MS has the advantages of less interference in the low mass range,better reproducibility and higher salt tolerance.It is highly suitable for the analysis of small molecule compounds.In recent years,researchers have developed a range of nanomaterials that are successfully applied to the field of small molecule drug and metabolite analysis including drug screening and quantification,drug delivery,metabolite profiling,biomarker discovery and so forth.This review summarizes the latest progress of SALDI-MS matrix materials such as metal-based,carbon-based,silica-based nanomaterials and organic framework nanomaterials and their applications.In addition,our perspective of SALDI-MS technology is also discussed for further advancement.
