Andropause refers to a generalized decline of male hormones, including testosterone and dehydroepiandrosterone in middle-aged and aging men. This decline in hormones has been associated with changes such as depression...Andropause refers to a generalized decline of male hormones, including testosterone and dehydroepiandrosterone in middle-aged and aging men. This decline in hormones has been associated with changes such as depression, loss of libido, sexual dysfunction, and changes in body composition. Aging has been associated with an abundance of concomitant diseases, in particular cardiovascular diseases, and although andropause is correlated to aging, a causal relationship between reduction of androgens and the development of chronic diseases such as atherosclerosis and heart failure has not been convincingly established yet. On the other hand, increasing data has emerged that revealed the effects of low levels of androgens on cardiovascular disease progression. As an example, low levels of testosterone have been linked to a higher incidence of coronary artery disease. Whether hormone replacement therapy that is used for andropausal men to alleviate symptoms of ＂male menopause＂ can halt progression of cardiovascular disease, remains controversially discussed, primarily due to the lack of well-designed, randomized controlled trials. At least for symptom improvement, the use of androgen replacement therapy in andropausal men may be clinically indicated, and with the appropriate supervision and follow up may prove to be beneficial with regard to preservation of the integrity of cardiovascular health at higher ages.展开更多
The most persistent criticism about the play Death of a Salesman （1949） concerns the issue of genre and its constituents： Is it a tragedy？! If yes, to what extend is it a tragedy？ Miller himself considered the pl...The most persistent criticism about the play Death of a Salesman （1949） concerns the issue of genre and its constituents： Is it a tragedy？! If yes, to what extend is it a tragedy？ Miller himself considered the play to be the tragedy of the common man, as he presents his idea on tragedy as a genre and his idea of the tragic hero in his essay ＂Tragedy and the Common Man＂ （1942）, but for a group of critics it is not a tragedy but to others and to the author, it is the tragedy of the man who tries to survive in the modern world by using archaic weapons. This paper briefly revisits the Aristotelian tragedy concept and modern theories, and stands on what are tragedy and a tragic hero. It aims at reading Death of a Salesman as a meeting point between （ancient） concept of tragedy with modern man and his way of seeing life, and briefly examines and explores the continuing disagreements among academics and by what criteria this play is a tragedy.展开更多
Through the use of broccolini innovation resources, a group of unique ex- cellent broccolini and male sterile lines, as well as inbred lines were bred. In the research, 4 hybrid strains were bred by the use of male st...Through the use of broccolini innovation resources, a group of unique ex- cellent broccolini and male sterile lines, as well as inbred lines were bred. In the research, 4 hybrid strains were bred by the use of male sterile lines which had vigorous growth, high resistance, good quality, good commodity and high yield, in- cluding Beauty No.l, Beauty No.2, Beauty No.3, Beauty No.4. The results showed that Beauty No.2 behaved the best comprehensive characters of high yield, high commercial value and good taste. The yield of Beauty No.2 was 28 185 kg/hm2 and 25% higher than the control Qianxiu, the sulforaphane content was as high as 48 mg/kg and 77.8%, 272.1% higher than the control of Qianxiu and Manuolv broc- coli, respectively. The comprehensive character of Beauty No.1 ranked the second, the yield was the highest （29 265 kg/hm2） and 30% than the control Qianxiu.展开更多
Objective The sex hormone and the corresponding receptor may play some roles in the development of the metabolic syndrome （MS） in the elderly men. This study was designed to examine the relationship of level of the ...Objective The sex hormone and the corresponding receptor may play some roles in the development of the metabolic syndrome （MS） in the elderly men. This study was designed to examine the relationship of level of the sex hormone and androgen receptor with MS in elderly men, thus to investigate the possible pathogenesis of MS. Methods This cross sectional study enrolled 587 elderly men, including 400 healthy controlls aged 62-92 years and 187 MS patients aged 60-87 years in Wan Shou Lu area of Beijing city. Dehydroepiandrosterone sulfate （DHAE-S）, total testosterone （TT）, sex hormone binding globulin （SHBG）, free testosterone （FT）, follicle-stimulating hormone （FSH）,Estradiol （E2）,luteinizing hormone（LH） and androgen receptor （AR） in blood were tested. Statistical analyses included the comparison analysis of variables and independent variables, correlation analysis using multi-factor linear regression, and multiple logistic regression analysis. Results DHAE-S, TT, SHBG, FT and AR fluorescence intensity in healthy control group were higher than those in MS group, however, FSH and E2 levels were lower in healthy group. Age was negatively correlated with diastolic blood pressure （DBP） and FT, but positively correlated with systolic blood pressure （SBP） and E2. AR fluorescence intensity was negatively correlated with SBP and LH. The logistic regression equation showed the negative correlation between DHEA-S, SHBG and the development of MS. Conclusions There are low levels of DHEA-S, TT, SHBG, FT and AR in the elderly patients with MS. On the contrary, FSH and E2 concentration are higher. It can be suggested that low levels of DHEA-S and SHBG may be the potential risk factors of MS in elderly men.展开更多
文摘Andropause refers to a generalized decline of male hormones, including testosterone and dehydroepiandrosterone in middle-aged and aging men. This decline in hormones has been associated with changes such as depression, loss of libido, sexual dysfunction, and changes in body composition. Aging has been associated with an abundance of concomitant diseases, in particular cardiovascular diseases, and although andropause is correlated to aging, a causal relationship between reduction of androgens and the development of chronic diseases such as atherosclerosis and heart failure has not been convincingly established yet. On the other hand, increasing data has emerged that revealed the effects of low levels of androgens on cardiovascular disease progression. As an example, low levels of testosterone have been linked to a higher incidence of coronary artery disease. Whether hormone replacement therapy that is used for andropausal men to alleviate symptoms of ＂male menopause＂ can halt progression of cardiovascular disease, remains controversially discussed, primarily due to the lack of well-designed, randomized controlled trials. At least for symptom improvement, the use of androgen replacement therapy in andropausal men may be clinically indicated, and with the appropriate supervision and follow up may prove to be beneficial with regard to preservation of the integrity of cardiovascular health at higher ages.
文摘The most persistent criticism about the play Death of a Salesman （1949） concerns the issue of genre and its constituents： Is it a tragedy？! If yes, to what extend is it a tragedy？ Miller himself considered the play to be the tragedy of the common man, as he presents his idea on tragedy as a genre and his idea of the tragic hero in his essay ＂Tragedy and the Common Man＂ （1942）, but for a group of critics it is not a tragedy but to others and to the author, it is the tragedy of the man who tries to survive in the modern world by using archaic weapons. This paper briefly revisits the Aristotelian tragedy concept and modern theories, and stands on what are tragedy and a tragic hero. It aims at reading Death of a Salesman as a meeting point between （ancient） concept of tragedy with modern man and his way of seeing life, and briefly examines and explores the continuing disagreements among academics and by what criteria this play is a tragedy.
基金Supported by Guangdong Science and Technology Planning Program(2011B020401002)~~
文摘Through the use of broccolini innovation resources, a group of unique ex- cellent broccolini and male sterile lines, as well as inbred lines were bred. In the research, 4 hybrid strains were bred by the use of male sterile lines which had vigorous growth, high resistance, good quality, good commodity and high yield, in- cluding Beauty No.l, Beauty No.2, Beauty No.3, Beauty No.4. The results showed that Beauty No.2 behaved the best comprehensive characters of high yield, high commercial value and good taste. The yield of Beauty No.2 was 28 185 kg/hm2 and 25% higher than the control Qianxiu, the sulforaphane content was as high as 48 mg/kg and 77.8%, 272.1% higher than the control of Qianxiu and Manuolv broc- coli, respectively. The comprehensive character of Beauty No.1 ranked the second, the yield was the highest （29 265 kg/hm2） and 30% than the control Qianxiu.
文摘Objective The sex hormone and the corresponding receptor may play some roles in the development of the metabolic syndrome （MS） in the elderly men. This study was designed to examine the relationship of level of the sex hormone and androgen receptor with MS in elderly men, thus to investigate the possible pathogenesis of MS. Methods This cross sectional study enrolled 587 elderly men, including 400 healthy controlls aged 62-92 years and 187 MS patients aged 60-87 years in Wan Shou Lu area of Beijing city. Dehydroepiandrosterone sulfate （DHAE-S）, total testosterone （TT）, sex hormone binding globulin （SHBG）, free testosterone （FT）, follicle-stimulating hormone （FSH）,Estradiol （E2）,luteinizing hormone（LH） and androgen receptor （AR） in blood were tested. Statistical analyses included the comparison analysis of variables and independent variables, correlation analysis using multi-factor linear regression, and multiple logistic regression analysis. Results DHAE-S, TT, SHBG, FT and AR fluorescence intensity in healthy control group were higher than those in MS group, however, FSH and E2 levels were lower in healthy group. Age was negatively correlated with diastolic blood pressure （DBP） and FT, but positively correlated with systolic blood pressure （SBP） and E2. AR fluorescence intensity was negatively correlated with SBP and LH. The logistic regression equation showed the negative correlation between DHEA-S, SHBG and the development of MS. Conclusions There are low levels of DHEA-S, TT, SHBG, FT and AR in the elderly patients with MS. On the contrary, FSH and E2 concentration are higher. It can be suggested that low levels of DHEA-S and SHBG may be the potential risk factors of MS in elderly men.
