This letter presents a programmable single-chip architecture for Multi-lnput and Multi-Output （M1MO） OFDM baseband receiver. The architecture comprises a Single Instruction Multiple Data （SIMD） DSP core and three ...This letter presents a programmable single-chip architecture for Multi-lnput and Multi-Output （M1MO） OFDM baseband receiver. The architecture comprises a Single Instruction Multiple Data （SIMD） DSP core and three coprocessors that are used for synchronization, FFT and channel decoder. In this MIMO OFDM system, the Zero Correlation Zone （ZCZ） code is used as the synchronization word preamble of packet in the physical layer in order to avoid the interference from other transmitting antennas. Furthermore, a simple channel estimation algorithm is proposed which is appropriate tbr the SIMD DSP computation.展开更多
CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of C...CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expression. Even though it fails to induce overt phenotypic changes, we find that CD8 ligation profoundly alters transcription in the T-cell clone, at a scale comparable to that induced by antibody-mediated ligation of CD3. The character of the resulting changes is distinct, however, with the net effect of CD8 ligation being substantially inhibitory. We speculate that ligating CD8 induces weak, T-cell receptor （TCR）-mediated inhibitory signals reminiscent of the effects of TCR antagonists. Our results imply that CD8 ligation alone is incapable of activating the T-cell clone because it fails to fully induce NFAT-dependent transcription.展开更多
As the traditional RISC+ASIC/ASSP approach for network processor design can not meet the today’s requirements, this paper described an alternate approach, Reconfigurable Processing Architecture, to boost the performa...As the traditional RISC+ASIC/ASSP approach for network processor design can not meet the today’s requirements, this paper described an alternate approach, Reconfigurable Processing Architecture, to boost the performance to ASIC level while reserve the programmability of the traditional RISC based system. This paper covers both the hardware architecture and the software development environment architecture.展开更多
There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable...There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable instruction set is an effective method to gain embedded system's re-configurability. This letter presents a logic module for Java processor to be capable of using programmable instruction set. Cost (area, power, and timing) of the module is trivial. Such module is also reusable for other embedded system solutions besides Java systems.展开更多
The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS ...The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling.展开更多
基金Supported by the National Natural Science Foundation of China (No.60476013).
文摘This letter presents a programmable single-chip architecture for Multi-lnput and Multi-Output （M1MO） OFDM baseband receiver. The architecture comprises a Single Instruction Multiple Data （SIMD） DSP core and three coprocessors that are used for synchronization, FFT and channel decoder. In this MIMO OFDM system, the Zero Correlation Zone （ZCZ） code is used as the synchronization word preamble of packet in the physical layer in order to avoid the interference from other transmitting antennas. Furthermore, a simple channel estimation algorithm is proposed which is appropriate tbr the SIMD DSP computation.
文摘CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expression. Even though it fails to induce overt phenotypic changes, we find that CD8 ligation profoundly alters transcription in the T-cell clone, at a scale comparable to that induced by antibody-mediated ligation of CD3. The character of the resulting changes is distinct, however, with the net effect of CD8 ligation being substantially inhibitory. We speculate that ligating CD8 induces weak, T-cell receptor （TCR）-mediated inhibitory signals reminiscent of the effects of TCR antagonists. Our results imply that CD8 ligation alone is incapable of activating the T-cell clone because it fails to fully induce NFAT-dependent transcription.
文摘As the traditional RISC+ASIC/ASSP approach for network processor design can not meet the today’s requirements, this paper described an alternate approach, Reconfigurable Processing Architecture, to boost the performance to ASIC level while reserve the programmability of the traditional RISC based system. This paper covers both the hardware architecture and the software development environment architecture.
基金Supported by the Guangzhou Key Technology R&D Program (No.2007Z2-D0011)
文摘There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable instruction set is an effective method to gain embedded system's re-configurability. This letter presents a logic module for Java processor to be capable of using programmable instruction set. Cost (area, power, and timing) of the module is trivial. Such module is also reusable for other embedded system solutions besides Java systems.
基金supported by Training Program of the National Major Research Plan(91339108)General Program(81370362,81170246)of the National Natural Science Foundation of Chinathe National Basic Research Program of China(2014CB542300)
文摘The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling.
