Icon memory research under different time pressures and icon quantities based on event-related potential

In order to obtain related brain electrical components and neural bases of physiology assessment of icon elements in a digital human-computer interface the modified sample-delay matching task experimental paradigm is used under different time pressures 4 000 and 2 000 ms and different icon quantities three five and ten icons on icon memory based on event-related potential ERP technology.Experimental results demonstrate that P300 has significant volatility changes and the maximum amplitude around the middle line of the parietal area PZ and P200 has obvious volatility changes around the middle line of the frontal and central area FCZ during icon cognition.P300 and P200 amplitudes increase as tasks become more difficult.Thus P300 latency is positively correlated with task difficulty. ERP research on the characteristics of icon memory will be an important reference standard in guiding user neurocognitive behavior and physiology assessment on interface usability.

Dependent mechanism of Chinese prepositions processing in the brain:evidence from event-related potentials

Objective To compare the event-related potentials （ERPs） waves of verbs and prepositions in the brain. Methods We recorded ERPs in the brain while participants judged the legality of the collocation for verbs and ＂preposition＂. Results Both verbs and prepositions elicited a negativity at the frontal site in 230-330 ms and 350-500 ms window. No difference was seen in 230-330 ms and 350-500 ms window; In difference waves, a negativity was elicited in the left and fight hemisphere at about 270-400 ms and 470-600 ms window for both open and closed-class words. Conclusion These may demonstrate that prepositions in modem Chinese are probably not a separate class from verbs and that N280 may be not a specific component for only prepositions （or closed-class words）.

同一区域汉族大学生面孔识别内群体效应的ERP研究

本文旨在考察汉族大学生对内外群体成员面孔的再认是否表现出明显的内群体效应。方法:实验以28位在校汉族大学生为被试,以内外群体(汉族和壮族)成员的中性面孔作为刺激材料,使用学习-再认实验范式进行研究。结果:(1)相对于外群体成员面孔的辨认,汉族大学生对内群体成员面孔辨认的正确率、反应时都没有显示出优势,内群体效应不显著;(2)但在识别内外群体成员面孔时,其虚报率显著,汉族大学生再认汉族面孔时虚报率偏高;再认阶段被试对不同图片类型的辨别力d′差异不显著;(3)汉族大学生面孔识别时,受熟悉度以及面孔特征等因素影响,识别内群体成员面孔时诱发的P1、N170潜伏期和峰值以及P2、N250波幅与识别外群体成员面孔时诱发的脑电差异都不显著。结论:随着民族间文化交流的深入,高校学生间交往的密切,熟悉度的增加,面孔识别过程中不一定存在内群体效应。

Effects of acute aerobic exercise on response preparation in a Go/No Go Task in children with ADHD:An ERP study

Purpose： The purpose of this study was to investigate the impact of acute exercise on reaction time and response preparation during a Go/No Go Task in children with attention deficit hyperactivity disorder （ADHD）. Methods： Nineteen children with ADHD （aged between 8 and 12 years old） undertook a 30-min intervention that consisted of treadmill running or video-watching presented in a counterbalanced order on different days. A Go/No Go Task was administrated after exercise or video-watching. Results： The results indicated a shorter reaction time and smaller contingent negative variation （CNV） 2 amplitude following exercise relative to the video-watching. For event related potential （ERP） analyses, greater CNV l and CNV 2 amplitudes in response to No Go stimuli in com- parison to Go stimuli was observed in the video-watching session only. Conclusion： These findings suggest that acute exercise may benefit children with ADHD by developing appropriate response preparation, particularly in maintaining a stable motor preparatory set prior to performing the given task.

Effects of acute aerobic exercise on motor response inhibition:An ERP study using the stop-signal task

Purpose： The purpose of this study was to determine the effects of acute exercise on motor response inhibition using both behavioral and electrophysiological approaches. Methods： The P3 and N1 event-related potential （ERP） components were recorded while performing a stop-signal task in 21 college students following a moderately intense acute exercise bout for 30 min and a sedentary control session that involved reading. Results： Acute exercise induced a shorter stop signal response time （SSRT） as compared to control; however, the go response time （Go RT） remained unchanged. In examining the ERP data, acute exercise increased both P3 amplitude and latency but did not affect the N1 component. Conclusion： Acute exercise has a selective and beneficial effect on cognitive function, specifically affecting the motor response inhibition aspect of executive function. Furthermore, acute exercise predominately impacts later stages of information processing during motor response inhibition, which may lead to an increase in attentional resource allocation and confer the ability to successfully withhold a response to achieve motor response inhibition.

Dissociated neural potential for processing strategies between decimals and fractions

The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decimal strategies in magnitude processing of nonsymbolic entities and symbolic numbers.The experimental results show that continuous entities elicit stronger left-lateralized anterior N2 in decimals,while discretized ones elicit more significant right-lateralized posterior N2 in fractions during the identification stage.On the other hand,decimals elicit stronger N2 over the left-lateralized fronto-central sites while fractions elicit the more profound P2 over the right-lateralized fronto-central sites and N2 at biparietal regions during the semantic access stage.Hence,for nonsymbolic entity processing,alignments of decimals and continuous entities activate the phonological network,while alignments of fractions and discretized entities trigger the visuospatial regions.For symbolic numbers processing,exact strategies with rote arithmetic retrieval in verbal format are used in decimal processing,while approximate strategies with complex magnitude processing in a visuospatial format are used in fraction processing.

Effects of creative expression program on the event-related potential and task reaction time of elderly with mild cognitive impairment

Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.

PRELIMINARY STUDY OF THREE- TONE PARADIGM AUDITORY P300 ON AGING DEMENTIA

Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditional P300 (2t- P300) and three- tone paradigm auditory P300 (3t- P300). The results of these two methods were compared. Results. Abnormal P300 was found in 18 of 34 dementia cases (52.9％ ) by 2t- P300, and in 26 of 30 patients who finished the 3t- P300 tests (86.7％ ). In 2t- P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2 severe cases showed abnormal results. In 3t- P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t- P300 was found in 13 of 16 cases which showed normal 2t- P300. Besides prolonged and bad- shaped P300, no certain response of P300 to rare non- target stimulus (r- nT) was found in 10 mild cases by 3t- P300. Conclusion. Three- tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r- nT in 3t- P300 is an important index in early diagnosis of mild dementia.

The N400 and LPC Effects Reflecting Controlled but Not Automatic Mechanisms of Sentence Processing

This study focused on the automatic versus controlled nature of the underlying cognitive processes of ERPs （Event-Related Potentials） effects during speech perception. ERPs to the final word of sentences （half being semantically incongruent with the sentence and half congruent） were presented to French natives under 4 levels of degradation： no degradation, mild degradation （2 levels）, and strong degradation. Under mild degradation allowing controlled sentence-level processing according to behavioral data, the N400 effect （i.e., the N400 to incongruent words minus the N400 to congruent words） and a late positive complex were delayed and the latter effect was reduced. Under strong degradation allowing only automatic sentence processing according to behavioral data, no ERP effects remained. These results suggest that, unlike contextual effect found with single words （e.g., using word-pair or word-list paradigms）, ERP effects elicited by more complex contexts such as full sentences are generated by controlled but not by automatic mechanisms of speech processing.

Processing Relative Clauses in Chinese:Evidence from Event-Related Potentials

The interpretation of Chinese relative clauses has become of significant interest in sentence processing research, since some studies found that Chinese comprehension patterns violate the well-known universal subject relatives preference proposed by NAPH theory and proved by cross-linguistic studies. The current study uses the neuropsychological measure of ERP. It supports such a language-specific phenomenon, with the results showing that both subject- and object- modifying subject relatives eliciting larger ERP components than object relatives. The results suggest that object relatives are easier to process than subject relatives at both modifying positions, challenging the claim of universal subject preference for all languages. In addition, this study casts doubts on CWO and working memory-based DLT models despite results being compatible with them, and concludes that none of the current models are comprehensive enough to account for the data. Finally, this study offers a piece of evidence for the garden path effect caused by the surface NVN word order in the Chinese relative clause. All in all, this study adds to the evidence that processing preference is not universal. It contributes to a comprehensive model of how complex structures are processed.

Suppression dampens unpleasant emotion faster than reappraisal:Neural dynamics in a Chinese sample

The timing dynamics of regulating negative emotion with expressive suppression and cognitive reappraisal were investigated in a Chinese sample. Event-Related Potentials were recorded while subjects were required to view, suppress emotion expression to, or reappraise emotional pictures. The results showed a similar reduction in self-reported negative emotion during both strategies. Additionally, expressive suppression elicited larger amplitudes than reappraisal in central-frontal P3 component(340–480 ms). More importantly, the Late Positive Potential(LPP) amplitudes were decreased in each 200 ms of the 800–1600 ms time intervals during suppression vs. viewing conditions. In contrast, LPP amplitudes were similar for reappraisal and viewing conditions in all the time windows, except for the decreased amplitudes during reappraisal in the 1400–1600 ms. The LPP(but not P3) amplitudes were positively related to negative mood ratings, whereas the amplitudes of P3, rather than LPP, predict self-reported expressive suppression. These results suggest that expressive suppression decreases emotion responding more rapidly than reappraisal, at the cost of greater cognitive resource involvements in Chinese individuals.

Clinical study on Jin's three-needle therapy for post-stroke cognitive impairment

Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table,with 30 cases in each group.The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy.The treatment for both groups lasted four weeks.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores as well as amplitude and latency of potential 300(P300)were adopted to compare the between-group results before and after treatment.Results:Before treatment,there were no significant differences(all P>0.05)in MMSE and MoCA scores,P300 latency and P300 amplitude between the two groups.After 4 weeks of treatment,the MMSE and MoCA scores and P300 amplitudes were improved in both groups,and the P300 latencies became shorter.The results showed significant intra-group and between-group differences(all P<0.05).Conclusion:Based on the routine treatment,Jin's three-needle therapy is effective for PSCI.The mechanism is probably through its regulation on the patients'neuroelectrophysiology.

Single-trial ERP evidence for the three-stage scheme of facial expression processing

Using a rapid serial visual presentation paradigm, we previously showed that the average amplitudes of six event-related potential (ERP) components were affected by different categories of emotional faces. In the current study, we investigated the six discriminating components on a single-trial level to clarify whether the amplitude difference between experimental conditions results from a difference in the real variability of single-trial amplitudes or from latency jitter across trials. It is found that there were consistent amplitude differences in the single-trial P1, N170, VPP, N3, and P3 components, demonstrating that a substantial proportion of the average amplitude differences can be explained by the pure variability in amplitudes on a single-trial basis between experimental conditions. These single-trial results verified the three-stage scheme of facial expression processing beyond multitrial ERP averaging, and showed the three processing stages of "fear popup", "emotional/unemotional discrimination", and "complete separation" based on the single-trial ERP dynamics.

Unsuccessful letter–sound integration in English reading by native Chinese speakers: evidence from an event related potentials study

Integrating letters and sounds are essential for successful reading in alphabetic languages. It remains unclear if native speakers of non-alphabetic languages integrate letters and sounds in reading an alphabetic lan- guage in the same way as native alphabetic readers do. Chinese is a morpho-syllabic system （each character cor- responds to one syllable） and contrasts sharply with alphabetic languages such as English. Several fMRI studies have shown that native Chinese speakers apply their native language system to read English words. By using the cross- modal mismatch negativity （MMN） paradigm, we directly investigated letter-sound integration for reading in English among native Chinese speakers. To investigate the effect of native language background on letter-sound integration in second language reading, a group of native Korean English learners served as a comparison group. We compared MMN responses between an auditory only condition （only vowels presented） and two audiovisual conditions （AV0, vowel presented synchronously with the corresponding letter; AV200, the letter presented 200 ms before the corresponding vowel） for both native Chinese and native Korean speakers. Native Chinese speakers demonstrated significantly attenuated MMN amplitudes in audiovisual conditions compared with the auditory only condition, regardless of their phonological decoding speed. In con- trast, native Korean speakers showed amplified amplitude MMN in AV200 compared with that in the auditory only condition. The results suggest that native language may shape the brain responses of second language learners to reading a second language in the early stages. Native non- alphabetic language speakers may be unable to use visual information to facilitate their phonological processing in the early stage while naT：lye alphabetic language speakers are capable of integrating letter sounds automatically.

Neural correlates of audio-visual modal interference inhibition investigated in children by ERP

In order to detect cross-sectional age characteristics of cognitive neural mechanisms in audio-visual modal interference inhibition,event-related potentials(ERP) of 14 10-year-old children were recorded while performing the words interference task.In incongruent conditions,the participants were required to inhibit the audio interference words of the same category.The present findings provided the preliminary evidence of brain mechanism for the children's inhibition development in the specific childhood stage.

A classification-based method to estimate event-related potentials from single trial EEG

A novel method based on machine learning is developed to estimate event-related potentials from single trial electroencephalography. This paper builds a basic framework using classification and an optimization model based on this framework for estimating event-related potentials. Then the SingleTrialEM algorithm is derived by introducing a logistic regression model, which could be obtained by training before SingleTrialEM is used, to instantiate the optimization model. The simulation tests demonstrate that the proposed method is correct and solid. The advantage of this method is verified by the comparison between this method and the Woody filter in simulation tests. Also, the cognitive test results are consistent with the conclusions of cognitive science.

Neural basis for successful encoding and retrieval of prospective memory

Prospective memory (PM) refers to memory for future intentions.Difference due to memory (Dm effect) is the difference in neural activity related to stimuli that were subsequently remembered or forgotten.Using event-related potentials (ERPs),the present study investigated the Dm effect for PM using a subsequent task-switching paradigm.The results showed that a Dm effect of ERP P150 was more positive-going for later PM hit trials than for later PM forgotten trials during 100–200 ms.This Dm effect may reflect the process for the production of future intention or the process for attention.Consistent with previously reported Dm effects of other types of memory,we found that the fbN2 (250–280 ms) and late positivity component (400–700 ms) were stronger in later PM hit trials than in forgotten trials.The fbN2 was evoked by Chinese characters.The late positivity component was related to the precise encoding process.In conclusion,because of the early P150,PM encoding appears to be somewhat different from previously identified Dm effects.However,further research is needed.Our findings reveal that Dm effects of PM share similar characteristics with known Dm effects of other types of episodic memory after the very early stage of neural processing.

Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults

Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with al- cohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant dif- ferences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It may also affect some blood biochemical indicators, but the specific mechanisms need further research.

The role of microglia in thalamic reticular nucleus in acupuncture regulating cognitive deficits in insomnia rats

Objective:To explore the mechanism of acupuncture in regulating cognitive deficits in insomnia rats by observing the effect of acupuncture on microglia in thalamic reticular nucleus(TRN).Methods:Thirty rats were randomly divided into a control group,a model group and an acupuncture group,with 10 rats in each group.The insomnia model was established by intraperitoneal injection of para-chlorophenylalanine(PCPA)once a day for 2 d.Rats in the control group were intraperitoneally injected with the same amount of normal saline.Rats in the acupuncture group received acupuncture at Neiguan(PC 6)and Zusanli(ST 36)for 5 consecutive days.The CLOCKLAB 2 data acquisition system was used to dynamically observe the sleep of the rats throughout the experiment.The cognition of rats was evaluated by event-related potentials(ERPs).After intervention,brain tissue was extracted.Immunofluorescence was used to test the fluorescence expression in TRN region.The concentrations of interleukin(IL)-1βand tumor necrosis factor(TNF)-αwere detected by enzyme-linked immunosorbent assay.Results:After intraperitoneal injection of PCPA suspension,the spontaneous activity in light period of rats in the model group and acupuncture group increased significantly compared with the control group(both P<0.01).After acupuncture treatment,the rats in the acupuncture group had much less spontaneous activity during the light period than those in the model group(P<0.01),and the results indicated that acupuncture could effectively improve the sleep quality of insomnia rats.Compared with the control group,rats in the model group showed that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αincreased significantly(all P<0.05),and the P3 amplitude decreased significantly(P<0.01).Compared with the model group,rats in the acupuncture group presented that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αwere significantly decreased(all P<0.05),and the amplitude of P3 was significantly increased(P<0.05).Conclusion:Acupuncture possesses an ability to improve the cognitive state in insomnia rats.The mechanism may be related to inhibiting the microglial activation,diminishing the levels of pro-inflammatory mediators like IL-1βand TNF-α,and promoting the recovery of central nervous system function.

Application of P300 in Scalp Acupuncture for Cognitive Disorder Due to Cerebral Infarction

Objective：To observe and compare the therapeutic effect of two different needling methods,liver-soothing and mind-regulating needling method versus conventional needling method,in treating anxiety and depression in tension-type headache.Methods：A total of 120 patients with tension-type headache coupled with anxiety and/or depression were randomized into two groups according to the random number table,a liver-soothing andmind-regulating needling group （group A） and a conventional needling group （group B）,60 patients in each group.The self-rating anxiety scale （SAS） and self-rating depression scale （SDS） were used for evaluation before and after treatment.The therapeutic effects of the two groups were compared after 2-treatment courses.Results：The values of SAS and SDS both significantly dropped in the two groups （P0.01）,and the differences between the two groups after treatment were statistically significant （P0.01,P0.05）.The therapeutic effect in group A was superior to that in group B （P0.01）.The 3-month follow-up study showed that the liver-soothing andmind-regulating needling method had better long-term effect in improving anxiety and depression than the conventional needling method （P0.05）.Conclusion：The liver-soothing andmind-regulating needling method can effectively relieve the anxiety and depression symptoms in patients with tension-type headache,and the long-term effect is also satisfactory.