本文综合了J Am Acad Dermatol 1990,23(3)上的部分文章,报道了一种新的口服抗真菌药伊康唑(itraconazole,ICZ)治疗花斑癣,表皮癣菌病,头癣,口腔、阴道念珠菌病,暗色丝孢霉病,孢子丝菌病,隐球菌病和曲霉菌病的临床疗效.结果表明:ICZ与...本文综合了J Am Acad Dermatol 1990,23(3)上的部分文章,报道了一种新的口服抗真菌药伊康唑(itraconazole,ICZ)治疗花斑癣,表皮癣菌病,头癣,口腔、阴道念珠菌病,暗色丝孢霉病,孢子丝菌病,隐球菌病和曲霉菌病的临床疗效.结果表明:ICZ与其它抗真菌制剂相比具有疗效高、毒副作用少、口服方便、对角蛋白亲和力高,停药后继续有效等特点,值得在临床上推广应用.展开更多
A 43-year-old man with a history of rheumatoid heart disease developed endocarditis.Blood culture showed endocarditis was caused by Kodamaea ohmeri and the susceptibility test showed the yeast species were susceptible...A 43-year-old man with a history of rheumatoid heart disease developed endocarditis.Blood culture showed endocarditis was caused by Kodamaea ohmeri and the susceptibility test showed the yeast species were susceptible to itraconazole,amphotericin B,and voriconazole,but susceptible-dose dependent to fluconazole,and resistant to 5-flucytosine.Treated with surgery and anti-fungi agents,the patient recovered from endocarditis.This is the first case of K.ohmeri fungemia found in Chinese from mainland.More and more evidence indicate that K.ohmeri is an important opportunistic pathogen for human beings.展开更多
This study evaluated the expression of N-acetyl-D-glucosamine, L-fucose, D-galactose and glucose/mannose on the cell wall surface of Aspergillus species using lectins and the in vitro antifungal activity of AMB （amph...This study evaluated the expression of N-acetyl-D-glucosamine, L-fucose, D-galactose and glucose/mannose on the cell wall surface of Aspergillus species using lectins and the in vitro antifungal activity of AMB （amphotericin B）, VOR （voriconazole） and ITC （itraconazole）. Con A （Concanavalin A）, WGA （wheat germ agglutinin）, UEA-I （Ulex europeus agglutinin I） and PNA （peanut agglutinin）, all conjugated with horseradish peroxidase, were used. For the susceptibility tests, sterilized fiat-bottomed 96-well microtitre plates were used and the procedures were followed of the Clinical and Laboratory Standard Institute. The inoculum was added to the wells with the tested drugs and the plates were incubated at 25 ℃ for 48 h before reading the results to determine the MIC （minimal inhibitory concentration） of AMB, VOR and ITC. All Aspergillus strains showed low MIC for AMB （0.031-1 μg/mL） and ITC （0.031-0.25μg/mL）. However, the isolates were less susceptible to VOR, for which the MIC ranged from 4 to 16 μg/mL. The results of this study indicate that the expression of N-acetyl-D-glucosamine and glucose/mannose on the cell wall surface of the Aspergillus species evaluated showed greater stability of expression in the fungal growth both in vitro and in parasitism.展开更多
This study aimed to analyze the clinical efficacy and safety of itraconazole. We investigated 68 patients with invasive fungal infections（IFI） in emergency intensive care unit（EICU）. A retrospective analysis was p...This study aimed to analyze the clinical efficacy and safety of itraconazole. We investigated 68 patients with invasive fungal infections（IFI） in emergency intensive care unit（EICU）. A retrospective analysis was performed in patients with IFI who were treated in the authors＇ institution, a grade III first class hospital in Beijing, China, between Feb. 2013 and Feb. 2015. The age of patients ranged from 35 to 90 years old with the mean age of（75.1±11.1） years old. The study population comprised 36 male and 32 female patients. Total response rate was 60.3%. The response rates in definitive diagnosis, clinical diagnosis and presumed diagnosis were 33.3%, 59.5% and 65.2%, respectively（P〈0.05）. The empirical treatment should be provided for patients with presumed diagnosis as earlier as possible. Eleven（16.2%） cases had adverse drug event（ADE） during treatment. The main signs were hepatic functional impairment and hypokalemia of ADE. The clinical efficacy and safety of intravenous itraconazole were precisely assessed. To reduce the adverse drug reaction（ADR）, hepatic and renal function and other biochemical criterion should be closely monitored.展开更多
It is known that the energy of the amorphous state of itraconazole loaded in ordered mesoporous materials is high relative to that of the crystalline state and is responsible for enhanced solubility and dissolution ra...It is known that the energy of the amorphous state of itraconazole loaded in ordered mesoporous materials is high relative to that of the crystalline state and is responsible for enhanced solubility and dissolution rate. We investigated the effects of particle size(0.7–5μm), mesostructure(2D p6 mm, cubic Ia-3d and cubic Fm-3m) and pore size(2.2–15.4 nm) of mesoporous silicas on the release performance of itraconazole. Results indicated that the release performance was not influenced by the particle sizes tested here, that the release performance increased with increasing pore diameter due to the lower probability of drug molecules colliding to recrystallize in large pores, and that the release performance was decreased in the cage-type pore structure(Fm-3m) compared to that in the cylindrical pore structures(p6mm and Ia-3d) because of the small entrance to the cagelike pores that retards the drug release.展开更多
文摘本文综合了J Am Acad Dermatol 1990,23(3)上的部分文章,报道了一种新的口服抗真菌药伊康唑(itraconazole,ICZ)治疗花斑癣,表皮癣菌病,头癣,口腔、阴道念珠菌病,暗色丝孢霉病,孢子丝菌病,隐球菌病和曲霉菌病的临床疗效.结果表明:ICZ与其它抗真菌制剂相比具有疗效高、毒副作用少、口服方便、对角蛋白亲和力高,停药后继续有效等特点,值得在临床上推广应用.
文摘A 43-year-old man with a history of rheumatoid heart disease developed endocarditis.Blood culture showed endocarditis was caused by Kodamaea ohmeri and the susceptibility test showed the yeast species were susceptible to itraconazole,amphotericin B,and voriconazole,but susceptible-dose dependent to fluconazole,and resistant to 5-flucytosine.Treated with surgery and anti-fungi agents,the patient recovered from endocarditis.This is the first case of K.ohmeri fungemia found in Chinese from mainland.More and more evidence indicate that K.ohmeri is an important opportunistic pathogen for human beings.
文摘This study evaluated the expression of N-acetyl-D-glucosamine, L-fucose, D-galactose and glucose/mannose on the cell wall surface of Aspergillus species using lectins and the in vitro antifungal activity of AMB （amphotericin B）, VOR （voriconazole） and ITC （itraconazole）. Con A （Concanavalin A）, WGA （wheat germ agglutinin）, UEA-I （Ulex europeus agglutinin I） and PNA （peanut agglutinin）, all conjugated with horseradish peroxidase, were used. For the susceptibility tests, sterilized fiat-bottomed 96-well microtitre plates were used and the procedures were followed of the Clinical and Laboratory Standard Institute. The inoculum was added to the wells with the tested drugs and the plates were incubated at 25 ℃ for 48 h before reading the results to determine the MIC （minimal inhibitory concentration） of AMB, VOR and ITC. All Aspergillus strains showed low MIC for AMB （0.031-1 μg/mL） and ITC （0.031-0.25μg/mL）. However, the isolates were less susceptible to VOR, for which the MIC ranged from 4 to 16 μg/mL. The results of this study indicate that the expression of N-acetyl-D-glucosamine and glucose/mannose on the cell wall surface of the Aspergillus species evaluated showed greater stability of expression in the fungal growth both in vitro and in parasitism.
文摘This study aimed to analyze the clinical efficacy and safety of itraconazole. We investigated 68 patients with invasive fungal infections（IFI） in emergency intensive care unit（EICU）. A retrospective analysis was performed in patients with IFI who were treated in the authors＇ institution, a grade III first class hospital in Beijing, China, between Feb. 2013 and Feb. 2015. The age of patients ranged from 35 to 90 years old with the mean age of（75.1±11.1） years old. The study population comprised 36 male and 32 female patients. Total response rate was 60.3%. The response rates in definitive diagnosis, clinical diagnosis and presumed diagnosis were 33.3%, 59.5% and 65.2%, respectively（P〈0.05）. The empirical treatment should be provided for patients with presumed diagnosis as earlier as possible. Eleven（16.2%） cases had adverse drug event（ADE） during treatment. The main signs were hepatic functional impairment and hypokalemia of ADE. The clinical efficacy and safety of intravenous itraconazole were precisely assessed. To reduce the adverse drug reaction（ADR）, hepatic and renal function and other biochemical criterion should be closely monitored.
文摘It is known that the energy of the amorphous state of itraconazole loaded in ordered mesoporous materials is high relative to that of the crystalline state and is responsible for enhanced solubility and dissolution rate. We investigated the effects of particle size(0.7–5μm), mesostructure(2D p6 mm, cubic Ia-3d and cubic Fm-3m) and pore size(2.2–15.4 nm) of mesoporous silicas on the release performance of itraconazole. Results indicated that the release performance was not influenced by the particle sizes tested here, that the release performance increased with increasing pore diameter due to the lower probability of drug molecules colliding to recrystallize in large pores, and that the release performance was decreased in the cage-type pore structure(Fm-3m) compared to that in the cylindrical pore structures(p6mm and Ia-3d) because of the small entrance to the cagelike pores that retards the drug release.
