伊白沙坦治疗108例原发性高血压的疗效观察

目的观察伊白沙坦治疗原发性高血压(简称高血压)的疗效。方法采用随机平行对照方法,将216例原发性高血压患者分成2组,治疗组(n=108)给伊白沙坦;对照组(n=108)口服依那普利片,疗程均8周。结果治疗8周后伊白沙坦组总有效率91.67%明显高于依那普利组79.63%,差异有统计学意义(P<0.05)。结论伊白沙坦治疗原发性高血压疗效好,不良反应少。

伊白沙坦治疗原发性高血压40例疗效分析

目的研究伊白沙坦治疗原发性高血压的临床疗效,观察对脂质和血糖的影响。方法80例原发性高血压患者,随机分为治疗组和对照组,治疗组采用伊白沙坦治疗,对照组采用硝苯地平治疗,疗程均为4周。结果治疗组显效32例(82.5%),有效5例(12.5%),总有效率为95%。对照组显效22例(55%),有效10例(25%),总有效率为80%。两组差异显著(P<0.05),两组降压幅度比较差异无显著性(P>0.05),两组对血糖、脂质的影响差异无显著性(P>0.05)。结论伊白沙坦能明显降低血压而对血糖、血脂无不良影响。

伊白沙坦治疗原发性高血压疗效分析

目的研究伊白沙坦治疗原发性高血压的临床疗效并观察对脂质和血糖的影响。方法120例原发性高血压患者,随机分为治疗组和对照组,治疗组采用伊白沙坦治疗,对照组给予硝苯地平治疗。结果治疗组显效50例(83.3%),有效7例(11.7%),总有效率为95.0%;对照组显效33例(55.0%),有效15例(25.0%),总有效率为80.0%,两组差异显著(P<0.05),两组降压幅度比较无显著性(P>0.05),两组对血糖、脂质地影响差异无显著性(P>0.05)。结论伊白沙坦能明显降低血压,而对血糖、脂质无不良影响。

药物治疗原发性高血压的临床观察与分析

目的观察分析伊白沙坦等联合用药治疗高血压的临床效果。方法本组98例,随机分为2组,治疗组口服厄贝沙坦150mg,1次/d,阿替洛尔12.5mg,2次/d;氢氯塞嗪25mg,1次/d。对照组口服硝苯地平10mg,3次/d,氢氯塞嗪25mg,1次/d。两组患者均连续服药4周,进行记录分析。结果治疗组:显效38例(76%),有效11例(22%),无效1例(2%)。总有效率:49例(98%);对照组:显效23例(47.91%),有效14例(29.16%),无效11例(22.91%)。总有效率:37例,占77.08%。两组比较,有差异显著性(P<0.05)。结论伊白沙坦和小剂量阿替洛尔及氢氯塞嗪联合治疗高血压伴糖尿病,冠心病、脑梗死及心力衰竭等,效果好,副作用少,具有一定的临床价值。

Pharmacokinetics of Ivermectin in Salvelinus leucomaenis Following Two Ways of Administration

[Objective] This study was aimed to study the pharmacokinetics of iver- mectin in Salvelinus leucomaenis following a single oral administration or intraperi- toneal injection. [Method] After a single oral administration or intraperitoneal injection of ivermectin with a dosage of 0.3 mg/kg body weight, samples were taken at dif- ferent time points and determined by high-performance liquid chromatography-ultravi- olet detection （HPLC-UV）. The pharmacokinetic parameters were calculated by 3p97 software. [Result] The concentration-time relations of ivermectin in plasma, muscle, liver and kidney were well described by one-department open model with first-order absorption. After oral administration, the pharmacokinetic parameters in plasma were as follows： Tmax=4.503 h, Cmax=0.252mg/L, t1/2ka=0.476 h, t1/2ka=331.160 h, AUC=121.524 （mg/L） .h. After intraperitoneal injection, the pharmacokinetic parameters in plasma were as follows： Tmax=2.751 h, Cmax=0.230 mg/L, t1/2ka=0.306 h, t1/2ka=153.868 h, AUC= 51.689 （mg/L） .h. [Conclusion] There were differences in the pharmacokinetics of ivermectin in Salvelinus leucomaenis between two different administration routes, and intraperitoneal injection led to more rapid absorption than oral administration.

血管紧张素Ⅱ受体拮抗剂的临床应用现状

血管紧张素Ⅱ（ AngⅡ）受体（ AT）拮抗剂是一类新型降压药，它在受体水平拮抗循环和局部 AngⅡ作用，成为当今抗高血压药物治疗的新观念和新方法。据 Dotamonitor报道，本世纪抗高血压药的市场将由 AT拮抗剂支配。

Spatio-temporal Variation of Arctic Sea Ice in Summer from 2003 to 2013

The variation in Arctic sea ice has significant implications for climate change due to its huge influence on the global heat balance. In this study, we quantified the spatio-temporal variation of Arctic sea ice distribution using Advanced Microwave Scanning Radiometer(AMSR-E) sea-ice concentration data from 2003 to 2013. The results found that, over this period, the extent of sea ice reached a maximum in 2004, whereas in 2007 and 2012, the extent of summer sea ice was at a minimum. It declined continuously from 2010 to 2012, falling to its lowest level since 2003. Sea-ice extent fell continuously each summer between July and mid-September before increasing again. It decreased most rapidly in September, and the summer reduction rate was 1.35 × 10~5 km^2/yr, twice as fast as the rate between 1979 and 2006, and slightly slower than from 2002 to 2011. Area with >90% sea-ice concentration decreased by 1.32 × 10~7 km^2/yr, while locations with >50% sea-ice concentration, which were mainly covered by perennial ice, were near the North Pole, the Beaufort Sea, and the Queen Elizabeth Islands. Perennial Arctic ice decreased at a rate of 1.54 × 10~5 km^2 annually over the past 11 years.

T2* magnetic resonance imaging of the liver in thalassemic patients in Iran

AIM: To investigate the accuracy of T2*-weighted magnetic resonance imaging (MRI T2*) in the evaluation of iron overload in beta-thalassemia major patients. METHODS: In this cross-sectional study, 210 patients with beta-thalassemia major having regular blood transfusions were consecutively enrolled. Serum ferritin levels were measured, and all patients underwent MRI T2* of the liver. Liver biopsy was performed in 53 patients at an interval of no longer than 3 mo after the MRIT2* in each patient. The amount of iron was assessed in both MRI T2* and liver biopsy specimens of each patient. RESULTS: Patients’ ages ranged from 8 to 54 years with a mean of 24.59 ± 8.5 years. Mean serum ferritin level was 1906 ± 1644 ng/mL. Liver biopsy showed a moderate negative correlation with liver MRI T2* (r = -0.573, P = 0.000) and a low positive correlation with ferritin level (r = 0.350, P = 0.001). Serum ferritin levels showed a moderate negative correlation with liver MRI T2* values (r = -0.586, P = 0.000). CONCLUSION: Our study suggests that MRI T2* is a non-invasive, safe and reliable method for detecting iron load in patients with iron overload.

A model of supplying poplar wood for Iranian paper & wood factories

The objective of this research is to design a method for an appropriate alternative to supply poplar wood as raw material for wood and paper factories in Iran. Due to the destruction of the forests and lack of proper plantation, replacement of the forest wood by the fast growing wood is vital to satisfy all requirements of these factories. A hierarchy was used to prioritize benefits, opportunities, costs and risks （BOCR） using the Analytic Hierarchy Process （AHP） ratings approach. To evaluate the ＂control criteria＂ of the system, a control hierarchy was also created and prioritized by applying the Analytic Network Process （ANP）. A total of four major control criteria in the system are prioritized where each one controls a network structure evaluated by using ANE The final synthesis results of the system showed that internal poplar tree farming supplied by the forest product factories was the best choice among three potential alternatives （factory procurement, external procurement and mix procurement）.

Muse Turned ＂Femme Fatale＂ in D. G. Rossetti＇s Painting and Poetry

In many of D. G. Rossetti＇s paintings, Elizabeth Siddal appears as a model. In real life, they formed a married couple, and the relatonship was not as idealistic as it might have been, between a muse-figure and an artist. After Elizabeth＇s death, Rossetti seemed to have been preoccupied with the ＂Lilith＂ theme in his painting and poetry and somehow he could not free himself from the haunting memory of the ＂wronged wife＂, the muse. This often found manifestation in his portrayal of the ＂femme fatale＂ images. Applying psychoanalysis to art-criticism and literary appreciation, this paper is an attempt to explore the relationship between a model and an artist, which both psychologically and aesthetically, seemed to be working beyond the former＇s death. Through a detailed analysis of the ＂Lilith＂ image in D. G. Rossetti＇s art, this paper has shown the coplexities of the artist＇s agony and anxiety over the image of a muse, a homely beloved--turned into a threatening ＂femme fatale＂, now distant, unknown, frightening yet fascinating, and mystified by death.

＂Had He a Hand to Write This？＂ Missing ＂Secretary＂ Hands

When Elizabethan＇s were trained to read and write, the handwriting they first learned was ＂Secretary＂ （or ＂Secretarial＂） hand, reflecting the style used by monks and scribes well back into the Middle Ages. Only in the mid-1500s did an alternative hand called ＂Italic＂ （or ＂Italianate＂） slowly begin to be adopted as a second hand, reflecting handwriting used on the continent, and Italic was rarer than Secretary until well after 1600. Today, extant Elizabethan handwriting samples normally show each person used both hand styles, and where only one hand is extant for a given person, it is usually a Secretary hand. Thus, it＇s a surprise that two noblemen, the great William Cecil, Lord Burghley, and his son-in-law Edward DeVere, the 17th Earl of Oxford, are each assumed to have only Italic hand samples among their voluminous collections of handwriting. Did they not learn and never use Secretary hands, or is it that any Secretary hands in their documents are simply presumed to be written by clerks？ This article begins with questioning whether the two men really were limited to Italic hands, fmds a few plausible Secretary hand samples for one of them （possibly for both）, reconstructs a hypothetical Italic alphabet for him, and nominates many candidate manuscripts （MSS, singular MS） for having been written or contributed to by him, some of which may be relevant to Shakespeare studies. Other subjects touched on are calligraphy, a clerk （or amanuensis）, and griffe de notaire （literally a ＂notary＇s scratch＂, or identifying scribble）.

The Feigned Madness of Ulysses and Hamlet： A Derridean Reading of Cartesian Cogito

Ulysses, the towering mythological figure and the hero of the world＇s most famous epic The Odyssey, put on the pretence of madness to shirk the Trojan War. This is not mentioned in Homer, but in Fabulae by Gaius Julius Hyginus. Similarly, Hamlet put on an ＂antic disposition＂ after the ghost exhorted him to kill King Claudius. In these two cases taken from mythology and literature, and pertaining to the Classical period and the Elizabethan age respectively, intelligent characters put on the pretence of madness, in their battle with society though they are in control of their senses. It is the aim of this paper to examine the dynamics of reason and non-reason when combined and brought so close to one another, that they could be easily confounded, in light of Derrida＇s reading of Descartes＇ formulations about reason. Since the two examined works pertain to the Classical and Elizabethan ages respectively, the paper will shed light on the historical background of madness in these periods to give a broader perspective of reason and madness in these works.

Different Characters and Destines of Four Sisters in Little Women

Little Women is a novel published in1868 and written by American author Louisa May Alcott. The story concerns the lives and loves of four sisters growing up during the American Civil War. It was based on Alcott＇s own experiences as a child in Concord, Massachusetts with her three sisters, Anna, May, and Elizabeth. It is a story about love, faith, fortitude, and devotion. And this paper aims at analyzing the four sisters＇ different characters and destinies and tries to give readers a new understanding about this novel.

Hypothetical Earlier Dating for The Passionate Pilgrim and First Folio

Did part or all of Shakespeare＇s The Passionate Pilgrim （TPP） actually predate 1593 Venus ＆ Adonis （V＆A） and 1594 Rape ofLuereee （RofL）？ Oddly enough, that may be the case, because the sole extant copy of its first edition has no title page, thus no date. Copies of its second edition do have a title page and are clearly dated 1599, plus a 1612 augmented project was marked ＂third edition＂. Thus, it should be significant that some of TPP＇s poetry have been found in manuscript or early publications back to the early 1590s, and in one case perhaps as early as 1585. But TPP may be a relic of a much larger anthology of poetry which possibly existed in manuscript circa 1589-94, was revised circa 1610-12 to accompany an intended publication of all of Shakespeare＇s works （poetry and drama）, but was not fully published until nearly three decades later. It is also notable that the 1640 anthology attributed to Shakespeare contained TPP plus lengthy poetic paraphrases from Ovid in much the same mold as V＆A and RofL. Moreover, the 1640 anthology may hold a key to radically earlier dating of the 1623 First Folio （F1）. We will briefly delve into the murky world of the Elizabethan publishing world of the 1580s and beyond, wherein the 17th Earl of Oxford＇s former servant, Anthony Munday, may have had an important role in the disposition of each ＂Shake-speare＂ work.

Shakespeare＇s Language Strategies in Hamlet

This study investigates the language strategies used by Shakespeare in The Tragedy of Hamlet, Prince of Denmark （1603）. Emphasis is given to the type of language or register Shakespeare provides his characters with in order to give them genuine or assumed identities. The linguistic register of the three major characters of Claudius, the Ghost, and Hamlet is explored in light of the Elizabethan cultural context. This concern with these three characters stems from the basic assumption of the paper that the play is a struggle between Claudius and the Ghost over Hamlet. Claudius speaks the language of a monarch which is informed by the code of society; the Ghost, who used to speak such language of sovereignty while alive, speaks a language of the dead informed by a newly acquired experience not familiar to human beings. On the other hand, Hamlet＇s use of language is the most peculiar in the play. His register keeps changing according to his tragic growth and his readiness for action. The study indicates that the language functions Shakespeare utilizes in Hamlet are numerous. Language is used creatively for a variety of purposes in addition to communication. The playwright employs language as a shield for self-defense, a tool for defining and hiding identity and misleading and manipulating others, a means of search for reality, and a tool for punishment, among other functions. The study findings invite further research into Shakespeare＇s use of language in his plays. No detailed in-depth studies of Shakespearean language and its implications exist.

Shakespeare＇ s Sonnets Dated

By using echoes in some sonnets to lines in certain plays, emphasizing those echoes which were not later repeated, and by applying dates to those plays, in 1926 Elizabeth Beckwith tentatively dated a third of the 154 in the entire sonnets cycle. Her belief was that an unintentional authorial pattern of usage would be less subjective than other approaches to dating the sonnets. Yet, by use of dates from external allusions later applied by Prof. Leslie Hotson and other scholars, this author suggests that it may be possible to extend the total number of datable sonnets to over half of the cycle. However, Beckwith did not use dates for the plays which were later to become a standard dating scheme accepted by most scholars today, and so adjustments of her dates would change the dates she awarded to many of her selected sonnets. This author suggests that even the standard dating scheme is flawed, particularly if Shakespeare was dead when the Sonnets were published in 1609. He suggests another dating regime that meshes quite well with both Beckwith＇s 52 and an additional 27. Thus, the result for the 79 sonnets is to avoid certain problems in the distribution that Beckwith＇s method generated. The net result is what Beckwith termed ＂a skeleton around which the remaining sonnets can be safely built＂, but for over half rather than only a third of the cycle. This author suggests a half＂skeleton＂ is more indicative of the chronology for the whole sonnets cycle than only a third.

Vision and Imagination in the Renaissance Theatre

To see what lacks representation on stage is a fully creative act that the spectator performs thanks to his or her imagination, as （s）he is called to retrieve via memory what is objectively absent from the scene. The Renaissance audience accomplished such a creative act by making use of rhetoric and figurative arts. However, it is pre-eminently words that trigger and support the imagination, as Shakespeare＇s drama best exemplifies. Both in the Elizabethan drama and in the Italian Renaissance theatre, with its perspectival vision, the spectator＇s creative act takes place in an ideal space where the stage space turns into the locus of stereoscopic vision. Consequently, the creation and consumption of the vision originates first and foremost in drama （comedy and tragedy）. The psychological, aesthetic, and anthropological mechanisms at the heart of vision, and the fruition of the images deriving from words, can be found as operating within the dramatic text, from the point of view of both the playwright and of the spectator/listener, in a direct relationship of cause and effect. Religious and especially Jesuitical drama, whose theatrical experience aims at discovering a correspondence between words and images, testifies to the visual power of the theatre.

An assessment of Charter airline benefits for Port Elizabeth and the Eastern Cape

Tourism is becoming a vital component for economic development in South Africa. The income generated by the tourism industry is about 6% of the GDP, which is significant but still falls short of the goal set by the White Paper on Tourism in 2000. In the light of South Africa hosting the 2010 Football World Cup, it is important to identify ways of sustainable tourism development that would continue to increase the benefits to the economy long after the event＇s over. The main objective of the research was to explore an idea for increasing the level of tourist income generated in the Port Elizabeth （Eastern Cape） area. The idea was researched by means of conducting a cost-benefit analysis of two tourist related projects. These projects would introduce Charter airline services between Europe and Port Elizabeth. A second objective was to identify constraints on the project or market failures which would prevent their implementation. The economic theory behind the operation of an airline showed that lease costs and aeroplane operating costs are the two most important factors determine Charter airline＇s profitability. In order to offset these costs, airlines must achieve high passenger load factors. Charter airlines have the advantage over scheduled airlines, in that they will only fly if a minimum level of people has pre-booked seats. Two aeroplanes were chosen for comparison purpose： an Airbus A 340-300 and a Boeing 767-300ER. The private benefits calculated were based on load factors between 80 and 95 percent for ticket prices of USD 667 and USD 773. In addition, to private costs and benefits, social benefits were also estimated in the form of additional secondary revenue generated. With the introduction of net social benefits, both projects become profitable. A 50 percent substitution of revenue generated by the Charter tourists reduces the profits for the both projects drastically. A project based on a Boeing 767-300ER is the most efficient project as it has the highest NPV and BCR values. A reduction in the lease cost of the Airbus 340-300 could make projects based on it more competitive. A few constraints on the establishment of a Charter airline operator based in Port Elizabeth are： the lack of adequate runway for the landing of the long-haul carriers and the need of a larger liberalisation of the aviation policy by eliminating protectionism. The cost benefit analysis undertaken in this research does not take into account social costs and benefits to the economy of establishing a Charter airline based in Port Elizabeth, such as an employment, infrastructure development and poverty alleviation. Nevertheless the analysis does suggest that there are strong private and social benefits warranting the establishment of an airline business between Europe and Port Elizabeth. The economic benefits of the tourism industry and its link to airline travel are outlined in section 3. It is shown that the growth of the airline industry is a major component and contributor to tourism growth.

Camel milk could be helpful in the treatment of asthma

Asthma is a chronic inflammatory disease with excessive irritability and airway narrowing and inflammation plays an important role in it.There are 300 million asthmatic people in the world currently.Main treatments for asthma include two groups of bronchodilators and inflammation controllers.Researches was continued in order to reach new treatments to reduce drug side effects and treatment-resistant cases or the types associated with weak treatment response.Today,World Health Organization recommends the application of traditional medicine especially in underdeveloped countries because of insufficient health resources and spread of diseases.Iranian traditional medicine(ITM)or Persian medicine is one of the oldest comprehensive traditional medicines with thousands years history which could help us to manage different diseases.The aim of this hypothesis is to investigate the camel milk as a complementary treatment of asthma because this chronic disease is sometimes resistant or response weakly to the treatment.In this article,the administration of camel milk in lung inflammatory diseases was studied by searching the PubMed and Scopus scientific databases.The results of this study indicated that camel milk due to having anti-inflammatory,immunomodulatory and anti-oxidant effects could decrease the levels of inflammatory factors such as tumor necrosis factorα,interleukin-17(IL-17),IL-6,IL-1B and transforming growth factor-β1 in a human and animal samples with inflammatory diseases.Besides,based on ITM,camel milk was used in treatment patients with asthma.But,clinical studies are needed to validate the effectiveness of camel milk in asthma and its mechanisms.

Genetic Polymorphism of Kappa Casein （K-CN）in Iraqi Buffalo Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism

This study was carried out the animal production department, genetic engineering lab, college of agriculture, （UoB）, Iraq. The aim of this study was to use the polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP） as a fast, efficient and low cost method to detect the genetic variants of kappa-casein gene （k-CN） in Iraqi buffalo using three different primers specific for bovine k-CN to amplify the gene segment, followed by digestion using restriction enzyme （Hind III） for genotyping. DNA from 50 Iraqi buffaloes was extracted by phenol chloroform method. PCR was carried out in a final reaction volume of 25 μL and the reaction mixture was subjected to standard PCR protocol. The results of this work show that among the examined 50 Iraqi Buffalo were homozygous for the K-CN and genotyped as BB for all three primers but gave different bands. Thus PCR-RFLP using Hind III revealed all the samples to be monomorphic for this locus. The restriction digestion analysis of 397 bp PCR product of k-CN indicates the presence of two fragments of 154 bp and 225 bp for BB-genotype. A 437 bp fragment of the bovine genomic K-CN gene was amplified. One Hind III restriction site is found in position 346 of the amplified fragment of allele k-CN B, yielded 91 bp and 346 bp. Amplified products from Iraqi buffalo （530）, after being digested with Hind III, yielded two separate DNA fragments of different sizes i.e., 160 bp and 370 bp. For the first time completed research such specifications in Iraq, for the first time using molecular biology in genetic identification. Our objectives of this study have been to aid in understanding domestication, Buffalo origin and their history and evolution, to identify genetically unique breeds, to provide an objective basis for conservation decisions and to aid the formulation of breeding plans.