伴嗜伊红细胞增多和全身性反应（drug reaction with eosinophilia and systemic symptoms，DRESS）综合征于1959年首次被认识。但直到1996年才被正式命名，是由于接触某些药物引起的，临床表现为皮疹、发热、内脏器官炎症、淋巴结病变...伴嗜伊红细胞增多和全身性反应（drug reaction with eosinophilia and systemic symptoms，DRESS）综合征于1959年首次被认识。但直到1996年才被正式命名，是由于接触某些药物引起的，临床表现为皮疹、发热、内脏器官炎症、淋巴结病变和嗜伊红细胞增多、血小板减少和非典型性淋巴细胞增多等血液学异常的综合征。该症病情较重，病死率高达10％。展开更多
Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, t...Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4,-10,-12B and-13,the IL-4 receptor, tumour necrosis factor (TNF)-α , STAT6, and interferon (IFN)-γ . Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that th e analysed genetic polymorphisms of cytokine genes do not appear to be associate d with AD susceptibility in our Chinese population.展开更多
文摘伴嗜伊红细胞增多和全身性反应（drug reaction with eosinophilia and systemic symptoms，DRESS）综合征于1959年首次被认识。但直到1996年才被正式命名，是由于接触某些药物引起的，临床表现为皮疹、发热、内脏器官炎症、淋巴结病变和嗜伊红细胞增多、血小板减少和非典型性淋巴细胞增多等血液学异常的综合征。该症病情较重，病死率高达10％。
文摘Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4,-10,-12B and-13,the IL-4 receptor, tumour necrosis factor (TNF)-α , STAT6, and interferon (IFN)-γ . Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that th e analysed genetic polymorphisms of cytokine genes do not appear to be associate d with AD susceptibility in our Chinese population.
