Objective MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR- 196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This met...Objective MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR- 196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk. Methods A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism. Results A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models （CT vs. TT, OR-1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR-1.08, 95%CI=1.01-1.14）. In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectat cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup. Conclusions The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.展开更多
Objective:Previous reports have shown that the gene promoter region of retinoic acid receptor β(RARβ) was hypermethylated in cervical carcinoma,implying the inhibition of gene transcription.The aim of this study was...Objective:Previous reports have shown that the gene promoter region of retinoic acid receptor β(RARβ) was hypermethylated in cervical carcinoma,implying the inhibition of gene transcription.The aim of this study was to investigate the association of cervical cancer development with the RARβ gene expression at the mRNA and protein level to assess the impact of RARβ as a marker for early detection of the cancer.Methods:We collected 126 cases of formalin fixed and paraffin embedded cervical tissue specimens as well as 37 cases of fresh tissue samples from women with cervicitis,cervical intraepithelial neoplasia(CIN) and cervical squamous cell carcinoma(CSCC).The RARβ mRNA and protein expression was detected by quantitative RT-PCR and immunohistochemistry,respectively.Results:(1) The mRNA expression of RARβ in CIN and cervical cancer was markedly decreased compared to cervicitis with a statistically very significant difference,but no difference was found between CIN and cervical cancer.(2) RARβ protein was normally expressed in the epithelial cells of cervicitis and partially lost in a few cases,but with the development of cervical lesion pathogenesis and cancer,a significant loss of protein expression was detected in CIN(38%) and CSCC(57%) compared to cervicitis(P < 0.01).Conclusion:The downregulation of RARβ transcription or loss of protein expression is an important indicator of cervical cancer and its precursur lesions.The detection of RARβ expression coupled with aberrant methylation of the gene may become a biomarker for the early prognosis or diagnosis of the cancer.展开更多
Most of the robots are nowadays evolving and imitating huiron social skills to achieve sociable interaction with humanas. Socially interactive robots require different characteristics than conventional robots. Likewis...Most of the robots are nowadays evolving and imitating huiron social skills to achieve sociable interaction with humanas. Socially interactive robots require different characteristics than conventional robots. Likewise human-human interaction, human-robot interaction is also accompanied with emotional interaction. Therefore, the robot＇s emotional expression is very important for human, especially facial expressions play an important role among the whole part of the human body. In this paper, we introduce a facial robot expression simulator FRESi.展开更多
Sense of science and technology has become the trend of modem design, but the commonly acknowledged sense of science and technology is different from science and technology itself. Starting from machine aesthetics and...Sense of science and technology has become the trend of modem design, but the commonly acknowledged sense of science and technology is different from science and technology itself. Starting from machine aesthetics and high-tech style, combined with the changing process of the sense of science and technology, it analyzes the causes and related social factors, style characteristics and manifestations of the sense of science and technology, as well as the inherent relationship of multi-angle analysis technology and the sense of science and technology. It illustrates the social value and defects of artistic expression of the sense of science and technology and reflects on the connection and difference between science and technology on the one hand and the sense of science and technology on the other hand.展开更多
Wano, spoken by about 7,000 native speakers, is a Papuan language of Trans-New Guinea Phylum, Dani-Kwerba Stock, which is found in the interior of Papua of the regency of Puncak Jaya. The language is closely related t...Wano, spoken by about 7,000 native speakers, is a Papuan language of Trans-New Guinea Phylum, Dani-Kwerba Stock, which is found in the interior of Papua of the regency of Puncak Jaya. The language is closely related to Dani, Walak, and Nggem. It is an SOV language typology that has a complex morphological system. Four spatial dimensions are morphosyntactically coded in elevative deixis, which are steepness/non-steepness distinction, proximity/distality distinction, adverbial/attributive expressions, and vertical/horizontal plane. This paper discusses the grammatical operation of a set of two-term system： ei ＂up＂ and ou ＂down＂ that serves as the basic forms for the elevational deixis in Wano.展开更多
Melanotic medullary carcinoma is extremely rare. We described a 35-year-old man who was found swelling in the left neck accidently, and no clinic evidences. A left total and right subtotal thyroidectomy and neck lymph...Melanotic medullary carcinoma is extremely rare. We described a 35-year-old man who was found swelling in the left neck accidently, and no clinic evidences. A left total and right subtotal thyroidectomy and neck lymph nodes dissection were done. Lymph nodes metastasis was not shown. Postoperative of four months, computerized tomography scan liver showed multiple focal lesion. Microscopic examination showed that abundant melanin pigmentation was observed in many of tumor cells. Tumor cells were diffusely immunopositive for vimentin, CK, CgA, syn, CEA, Calcitonin, HMB45, S-100 and negative for TG, TTF-1. Melanotic medullary carcinoma is very rare. It is necessary to report more cases for exact biological behavior and prognosis.展开更多
Through case studies in Ningbo, Dalian and Beijing, this article discusses how to promote public services, social integration and expression of residents＇ views in the construction of harmonious communities. The Ning...Through case studies in Ningbo, Dalian and Beijing, this article discusses how to promote public services, social integration and expression of residents＇ views in the construction of harmonious communities. The Ningbo case shows the origin, scale and effect of a government-led community public service network; the Dalian case describes the emergence, development and functions of community-led autonomous organizations as a means of promoting socially disadvantaged groups＇ integration into society; and the Beijing case reveals the value orientation, methods and constructive experience of community development evaluation based on the expression of residents＇ views.展开更多
基金supported by the National Natural Science Foundation of China(No.81071914)
文摘Objective MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR- 196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk. Methods A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism. Results A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models （CT vs. TT, OR-1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR-1.08, 95%CI=1.01-1.14）. In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectat cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup. Conclusions The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.
基金Supported by a grant from the Natural Science Foundation of China (No. 30760279)
文摘Objective:Previous reports have shown that the gene promoter region of retinoic acid receptor β(RARβ) was hypermethylated in cervical carcinoma,implying the inhibition of gene transcription.The aim of this study was to investigate the association of cervical cancer development with the RARβ gene expression at the mRNA and protein level to assess the impact of RARβ as a marker for early detection of the cancer.Methods:We collected 126 cases of formalin fixed and paraffin embedded cervical tissue specimens as well as 37 cases of fresh tissue samples from women with cervicitis,cervical intraepithelial neoplasia(CIN) and cervical squamous cell carcinoma(CSCC).The RARβ mRNA and protein expression was detected by quantitative RT-PCR and immunohistochemistry,respectively.Results:(1) The mRNA expression of RARβ in CIN and cervical cancer was markedly decreased compared to cervicitis with a statistically very significant difference,but no difference was found between CIN and cervical cancer.(2) RARβ protein was normally expressed in the epithelial cells of cervicitis and partially lost in a few cases,but with the development of cervical lesion pathogenesis and cancer,a significant loss of protein expression was detected in CIN(38%) and CSCC(57%) compared to cervicitis(P < 0.01).Conclusion:The downregulation of RARβ transcription or loss of protein expression is an important indicator of cervical cancer and its precursur lesions.The detection of RARβ expression coupled with aberrant methylation of the gene may become a biomarker for the early prognosis or diagnosis of the cancer.
基金supported by the MKE(The Ministry of Knowledge Economy,Korea)the ITRC(Information Technology Research Center)support program(ⅡTA-2008-C1090-0803-0006)
文摘Most of the robots are nowadays evolving and imitating huiron social skills to achieve sociable interaction with humanas. Socially interactive robots require different characteristics than conventional robots. Likewise human-human interaction, human-robot interaction is also accompanied with emotional interaction. Therefore, the robot＇s emotional expression is very important for human, especially facial expressions play an important role among the whole part of the human body. In this paper, we introduce a facial robot expression simulator FRESi.
文摘Sense of science and technology has become the trend of modem design, but the commonly acknowledged sense of science and technology is different from science and technology itself. Starting from machine aesthetics and high-tech style, combined with the changing process of the sense of science and technology, it analyzes the causes and related social factors, style characteristics and manifestations of the sense of science and technology, as well as the inherent relationship of multi-angle analysis technology and the sense of science and technology. It illustrates the social value and defects of artistic expression of the sense of science and technology and reflects on the connection and difference between science and technology on the one hand and the sense of science and technology on the other hand.
文摘Wano, spoken by about 7,000 native speakers, is a Papuan language of Trans-New Guinea Phylum, Dani-Kwerba Stock, which is found in the interior of Papua of the regency of Puncak Jaya. The language is closely related to Dani, Walak, and Nggem. It is an SOV language typology that has a complex morphological system. Four spatial dimensions are morphosyntactically coded in elevative deixis, which are steepness/non-steepness distinction, proximity/distality distinction, adverbial/attributive expressions, and vertical/horizontal plane. This paper discusses the grammatical operation of a set of two-term system： ei ＂up＂ and ou ＂down＂ that serves as the basic forms for the elevational deixis in Wano.
文摘Melanotic medullary carcinoma is extremely rare. We described a 35-year-old man who was found swelling in the left neck accidently, and no clinic evidences. A left total and right subtotal thyroidectomy and neck lymph nodes dissection were done. Lymph nodes metastasis was not shown. Postoperative of four months, computerized tomography scan liver showed multiple focal lesion. Microscopic examination showed that abundant melanin pigmentation was observed in many of tumor cells. Tumor cells were diffusely immunopositive for vimentin, CK, CgA, syn, CEA, Calcitonin, HMB45, S-100 and negative for TG, TTF-1. Melanotic medullary carcinoma is very rare. It is necessary to report more cases for exact biological behavior and prognosis.
基金This case study is an outcome of the cooperative research program"The Zhejiang Experience and the Development of China"carried out by CASS and Zhejiang Province.The research report was written by Ge Daoshun.
文摘Through case studies in Ningbo, Dalian and Beijing, this article discusses how to promote public services, social integration and expression of residents＇ views in the construction of harmonious communities. The Ningbo case shows the origin, scale and effect of a government-led community public service network; the Dalian case describes the emergence, development and functions of community-led autonomous organizations as a means of promoting socially disadvantaged groups＇ integration into society; and the Beijing case reveals the value orientation, methods and constructive experience of community development evaluation based on the expression of residents＇ views.
