Objective To screen and identify genetic loci affecting the active zone formation in C. elegans. Methods A SYD-2：：GFP reporter was constructed and used as an active zone marker for forward genetic screen to identify...Objective To screen and identify genetic loci affecting the active zone formation in C. elegans. Methods A SYD-2：：GFP reporter was constructed and used as an active zone marker for forward genetic screen to identify genetic loci affecting the active zone formation. Results Eight isolated mutant alleles were characterized from 15,000 haploid genomes. The SYD-2：：GFP phenotypes of these mutants are mainly reflected as the changes of number, morphology, distribution of puncta and the gaps appearance. Some mutants also exhibit visible behavioral or physical phenotypes, and aldicarb resistant or sensitive phenotypes. Conclusion These mutants provide the opportunity for further systematic research on the active zone formation and the neurotransmission.展开更多
In this study,we evaluate the forecast skill of the subseasonal-to-seasonal(S2S)prediction model of the Beijing Climate Center(BCC)for the boreal summer intraseasonal oscillation(BSISO).We also discuss the key factors...In this study,we evaluate the forecast skill of the subseasonal-to-seasonal(S2S)prediction model of the Beijing Climate Center(BCC)for the boreal summer intraseasonal oscillation(BSISO).We also discuss the key factors that inhibit the BSISO forecast skill in this model.Based on the bivariate anomaly correlation coefficient(ACC)of the BSISO index,defined by the first two EOF modes of outgoing longwave radiation and 850-hPa zonal wind anomalies over the Asian monsoon region,we found that the hindcast skill degraded as the lead time increased.The ACC dropped to below 0.5for lead times of 11 days and longer when the predicted BSISO showed weakened strength and insignificant northward propagation.To identify what causes the weakened forecast skill of BSISO at the forecast lead time of 11 days,we diagnosed the main mechanisms responsible for the BSISO northward propagation.The same analysis was also carried out using the observations and the outputs of the four-day forecast lead that successfully predicted the observed northward-propagating BSISO.We found that the lack of northward propagation at the 11-day forecast lead was due to insufficient increases in low-level cyclonic vorticity,moistening and warm temperature anomalies to the north of the convection,which were induced by the interaction between background mean flows and BSISO-related anomalous fields.The BCC S2S model can predict the background monsoon circulations,such as the low-level southerly and the northerly and easterly vertical shears,but has limited capability in forecasting the distributions of circulation and moisture anomalies.展开更多
This paper discusses a mathematical model for a liquid phase reacting flow occurring at the cathode of a patent pending novel fuel cell geometry, where a non homogeneous catalysis carried by gold and Prussian Blue, wi...This paper discusses a mathematical model for a liquid phase reacting flow occurring at the cathode of a patent pending novel fuel cell geometry, where a non homogeneous catalysis carried by gold and Prussian Blue, with the first reducing air O2 and the second the resulting H2O2. The breathing zone is porous walls microtubes, with three different types of pores in its walls. Inside the microtubes there is water solution of sulfuric acid. The microtubes possess an external layer of extremely porous polymer hydrophobic agent. A Prussian Blue thin porous layer is over the selective membrane. Appropriate porous and tubular connecting elements close the fluid loop. The asymmetry induces proper current and electric potential profiles, which leads to a mainly electrocapillary electrokinetic flow, which enhances the oxygen transport and assures the H2O2 flow to its reduction layer.展开更多
文摘Objective To screen and identify genetic loci affecting the active zone formation in C. elegans. Methods A SYD-2：：GFP reporter was constructed and used as an active zone marker for forward genetic screen to identify genetic loci affecting the active zone formation. Results Eight isolated mutant alleles were characterized from 15,000 haploid genomes. The SYD-2：：GFP phenotypes of these mutants are mainly reflected as the changes of number, morphology, distribution of puncta and the gaps appearance. Some mutants also exhibit visible behavioral or physical phenotypes, and aldicarb resistant or sensitive phenotypes. Conclusion These mutants provide the opportunity for further systematic research on the active zone formation and the neurotransmission.
基金supported by the National Basic Research Program of China (973 Program) (Grant No.2015CB453200)
文摘In this study,we evaluate the forecast skill of the subseasonal-to-seasonal(S2S)prediction model of the Beijing Climate Center(BCC)for the boreal summer intraseasonal oscillation(BSISO).We also discuss the key factors that inhibit the BSISO forecast skill in this model.Based on the bivariate anomaly correlation coefficient(ACC)of the BSISO index,defined by the first two EOF modes of outgoing longwave radiation and 850-hPa zonal wind anomalies over the Asian monsoon region,we found that the hindcast skill degraded as the lead time increased.The ACC dropped to below 0.5for lead times of 11 days and longer when the predicted BSISO showed weakened strength and insignificant northward propagation.To identify what causes the weakened forecast skill of BSISO at the forecast lead time of 11 days,we diagnosed the main mechanisms responsible for the BSISO northward propagation.The same analysis was also carried out using the observations and the outputs of the four-day forecast lead that successfully predicted the observed northward-propagating BSISO.We found that the lack of northward propagation at the 11-day forecast lead was due to insufficient increases in low-level cyclonic vorticity,moistening and warm temperature anomalies to the north of the convection,which were induced by the interaction between background mean flows and BSISO-related anomalous fields.The BCC S2S model can predict the background monsoon circulations,such as the low-level southerly and the northerly and easterly vertical shears,but has limited capability in forecasting the distributions of circulation and moisture anomalies.
文摘This paper discusses a mathematical model for a liquid phase reacting flow occurring at the cathode of a patent pending novel fuel cell geometry, where a non homogeneous catalysis carried by gold and Prussian Blue, with the first reducing air O2 and the second the resulting H2O2. The breathing zone is porous walls microtubes, with three different types of pores in its walls. Inside the microtubes there is water solution of sulfuric acid. The microtubes possess an external layer of extremely porous polymer hydrophobic agent. A Prussian Blue thin porous layer is over the selective membrane. Appropriate porous and tubular connecting elements close the fluid loop. The asymmetry induces proper current and electric potential profiles, which leads to a mainly electrocapillary electrokinetic flow, which enhances the oxygen transport and assures the H2O2 flow to its reduction layer.
