Latest advances in network sensor technology and state of the art of mobile robotics and artificial intelligence research can be applied to develop autonomous and distributed monitoring systems. Intelligent Space （iS...Latest advances in network sensor technology and state of the art of mobile robotics and artificial intelligence research can be applied to develop autonomous and distributed monitoring systems. Intelligent Space （iSpace） is an environmental system, which is able to support human in informative and physical ways. iSpace observing the space with distributed sensors, extracts useful information from the obtained data and provides various services to users. This means that essential functions of iSpace are ＂observation＂, ＂recognition＂ and ＂actuation.＂ In this paper, we focus on the observation function of iSpace. And we describe observation systems to get information of both human and mobile agents in the space to show new results.展开更多
Cardiac remodelling is generally accepted as a critical process in the progression of heart failure. Myocyte hypertrophy,inflammatory responses and cardiac fibrosis are the main pathological changes associated with ca...Cardiac remodelling is generally accepted as a critical process in the progression of heart failure. Myocyte hypertrophy,inflammatory responses and cardiac fibrosis are the main pathological changes associated with cardiac remodelling.AMP-activated protein kinase(AMPK) is known as an energy sensor and a regulator of cardiac metabolism under normal and ischaemic conditions. Additionally, AMPK has been shown to play roles in cardiac remodelling extending well beyond metabolic regulation. In this review, we discuss the currently defined roles of AMPK in cardiac remodelling and summarize the effects of AMPK on cardiac hypertrophy, inflammatory responses and fibrosis and the molecular mechanisms underlying these effects. In addition, we discuss some pharmacological activators of AMPK that are promising treatments for cardiac remodelling.展开更多
文摘Latest advances in network sensor technology and state of the art of mobile robotics and artificial intelligence research can be applied to develop autonomous and distributed monitoring systems. Intelligent Space （iSpace） is an environmental system, which is able to support human in informative and physical ways. iSpace observing the space with distributed sensors, extracts useful information from the obtained data and provides various services to users. This means that essential functions of iSpace are ＂observation＂, ＂recognition＂ and ＂actuation.＂ In this paper, we focus on the observation function of iSpace. And we describe observation systems to get information of both human and mobile agents in the space to show new results.
基金supported by the National Natural Science Foundation of China (81530009 to Youyi Zhang, 81670205 to Han Xiao)
文摘Cardiac remodelling is generally accepted as a critical process in the progression of heart failure. Myocyte hypertrophy,inflammatory responses and cardiac fibrosis are the main pathological changes associated with cardiac remodelling.AMP-activated protein kinase(AMPK) is known as an energy sensor and a regulator of cardiac metabolism under normal and ischaemic conditions. Additionally, AMPK has been shown to play roles in cardiac remodelling extending well beyond metabolic regulation. In this review, we discuss the currently defined roles of AMPK in cardiac remodelling and summarize the effects of AMPK on cardiac hypertrophy, inflammatory responses and fibrosis and the molecular mechanisms underlying these effects. In addition, we discuss some pharmacological activators of AMPK that are promising treatments for cardiac remodelling.
