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血液传播型肝炎的站内污染及其预防
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作者 耿秀凤 亓梅章 《实用医技杂志》 2001年第10期785-786,共2页
血液传播型肝炎主要包括乙型、丙型、丁型、己型和庚性等,其共同点是都可经血液、体液及肠外其它途径传播.因目前血站丁型、己型和庚型尚未列入常规检验,不作为调查对象.为了解本站内环境乙型、丙型肝炎的污染情况,提高工作人员对此类... 血液传播型肝炎主要包括乙型、丙型、丁型、己型和庚性等,其共同点是都可经血液、体液及肠外其它途径传播.因目前血站丁型、己型和庚型尚未列入常规检验,不作为调查对象.为了解本站内环境乙型、丙型肝炎的污染情况,提高工作人员对此类病毒的认识,加强预防和控制,于2000年8月应用ELISA法对本站内环境与有关物体表面做HBsAg、抗-HCV检测,报告如下. 展开更多
关键词 血液传播型肝炎 血站 污染 预防
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新型肝炎病毒的研究进展
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作者 于建国 史庆轩 商庆华 《人民军医》 2003年第3期163-165,共3页
关键词 肝炎病毒 研究进展 肝炎 肝炎 输血传播病毒肝炎
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2003年莱芜市中心血站站内环境乙型、丙型肝炎污染调查
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作者 耿秀凤 潘秀芳 《预防医学论坛》 2005年第1期87-87,共1页
关键词 2003年 莱芜市 中心血站 站内环境 肝炎 肝炎 抗-HCV HBSAG 传播型肝炎
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乙型肝炎病毒母婴传播及其阻断研究的现状与存在问题 被引量:18
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作者 邹怀宾 陈煜 +5 位作者 张华 段钟平 李杰 庄辉 梁晓峰 Calvin Q.Pan 《中华肝脏病杂志》 CAS CSCD 北大核心 2010年第7期556-558,共3页
HBV可经血液、母婴、性接触等多种途径传播,其中母婴传播是我国HBV传播的主要途径之一.乙型肝炎母婴阻断是指通过产前、产时,产后采取一系列措施对新生儿进行保护以减少感染HBV机会的方法.近年来,HBV的母婴阻断取得了较好效果,总体阻断... HBV可经血液、母婴、性接触等多种途径传播,其中母婴传播是我国HBV传播的主要途径之一.乙型肝炎母婴阻断是指通过产前、产时,产后采取一系列措施对新生儿进行保护以减少感染HBV机会的方法.近年来,HBV的母婴阻断取得了较好效果,总体阻断成功率约在90%以上,但仍有一定的失败率,在相关机制、方案优化等方面仍面临一些亟待解决的问题. 展开更多
关键词 肝炎病毒 母亲 婴儿 疫苗
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A randomized controlled clinical trial: Interruption of intrauterine transmission of hepatitis B virus infection with HBIG 被引量:26
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作者 Qin XH Lin Xi-ao +2 位作者 Xiao-Bo Lu Yue-Xin Zhang Xia Cai 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第21期3434-3437,共4页
AIM: To evaluate the efficacy of interruption of intrauterine infection of HBV with HBIG in pregnant women with positive HBeAg and HBsAg.METHODS: A prospective randomized controlled trial was adopted. Sixty cases wi... AIM: To evaluate the efficacy of interruption of intrauterine infection of HBV with HBIG in pregnant women with positive HBeAg and HBsAg.METHODS: A prospective randomized controlled trial was adopted. Sixty cases with positive HBeAg and HBsAg were coincident with the criteria of inclusion, and 8 cases were excluded. Fifty-two cases were analyzed (28 cases in trial group and 24 in control group). All cases in trial group received 200 IU HBIG intravenously every 4 wk for 3 times from the 28^th wk. The cases of control group received placebo in the same way. All pregnant women were detected for HBeAg and HBV-DNA at the beginning of the trial and end of the trial (delivery). The cord blood of all newborns were collected for detecting HBeAg and HBV-DNA simultaneously.RESULTS: For investigation of HBeAg of newborns in trial group, 6 of 28 cases of newborns had positive HBeAg, the HBeAg positive rate being 21.4%, the total rate of 95% CI being 8%-41%. In control group, 19 of 24 cases of newborns had positive HBeAg, HBeAg positive rate was 79.2%, the rate of 95%CI being 5%-93%. By statistical analysis, 2= 17.26, P 〈 0.01, RR = 0.27, 95% CI (6.3 × 10^-6, 8.6 × 10^-5). For investigation of HBV-DNA of newborns in trial group, 7 of 28 cases of newborns had positive HBV-DNA, HBV-DNA positive rate being 25%, the total rate of 95% CI being 11%-45%. In control group, 20 of 24 cases of newborns had positive HBV-DNA, HBV-DNA positive rate was 83.3%, the total rate of 95% CI being 63%-95%. By statistical analysis, X^2 = 17.62, P 〈 0.01, RR = 0.30, 95% CI (1.5 × 10^-5, 1.7× 10^-4). The results indicated that there was significant difference in HBeAg positive rate and HBV-DNA positive rate of newborns between the two groups. In trial group, 7 of 28 newborns had HBV-DNA positive, but the HBV-DNA load of newborns was lower than that of their mothers. In control group, 20 of 24 newborns still had HBV-DNA positive, and the HBV-DNA load of newborns was close to those of their mothers. Statistical analysis indicated that there was no significant difference in HBV- DNA load between postnatal women without HBIG intervention and their filial generations (T = 81.5, P 〉 0.1). CONCLUSION: It is effective and safe to prevent intrauterine infection of HBV with HBIG from the 28^th wk in pregnant women with positive HBeAg and HBsAg. In clinical application, those pregnant women with negative HBeAg and positive HBV-DNA also need to be interrupted by HBIG. 展开更多
关键词 INTERRUPTION INTRAUTERINE TRANSMISSION Hepatitis B virus HBIG
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Risk factors affecting the mother-to-infant transmission of hepatitis B virus: a meta analysis 被引量:2
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作者 李晶华 邵中军 +3 位作者 王宗仁 马静 龙铟 姚菊峰 《Journal of Medical Colleges of PLA(China)》 CAS 2006年第4期268-273,共6页
Objective:To search for risk factors that affect mother-to-infant transmission of hepatitis B virus(HBV). Methods:To obtain studies eligible for meta-analysis, China biological medicine discs and MEDLINE citations... Objective:To search for risk factors that affect mother-to-infant transmission of hepatitis B virus(HBV). Methods:To obtain studies eligible for meta-analysis, China biological medicine discs and MEDLINE citations were surveyed. Mother HBV DNA or HBeAg positivity,neonate HBeAg positivity, mode of delivery, threatened abortion and threatened premature labor were processed with meta analysis. Criteria for selection of published studies for meta analysis were based on principle by Abdolmaleky HM. Odds ratio (OR) was calculated and summarized by fixed effect model or random-effects model using RevMan software. The heterogeneity of the group of ORs was assessed using an X^2 test. The significance of the pooled OR was determined by the u-test. The strength of association was assessed using the OR. An OR〉1. 0 indicated a positive association between the risk factor and neonate HBV infection. Results: After meta analysis of factors concerned, a significant association was found between the positivity of HBeAg in mother and neonate, of HBV DNA in mother peripheral serum, and HBV mother-to-infant transmission, with a pooled OR equal to 19.43 (95% CI=8. 77-43. 06), 36.5 (95% CI= 19.85-67. 11), and 36.5 (95 % CI= 19.85-67.11 ) respectively. Mode of delivery, threatened abortion and threatened premature labor proved not to be of risk factors on the mother-to-infant transmission of HBV. Conclusion: Mother HBV DNA or HBeAg positivity and neonate HBeAg positivity were proved to be of risk factors affecting the transmission of HBV from mother to fetal. 展开更多
关键词 mother-to-infant transmission hepatitis B virus risk factor
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Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission 被引量:11
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作者 Tao Shen Xin-Min Yan Yun-Lian Zou Jian-Mei Gao Hong Dong 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第37期5674-5682,共9页
AIM: To determine whether HBV with the same characteristics causes dissimilar mutations in different hosts. METHODS: Full-length HBV genome was amplified and linked with pMD T18 vector. Positive clones were selected b... AIM: To determine whether HBV with the same characteristics causes dissimilar mutations in different hosts. METHODS: Full-length HBV genome was amplified and linked with pMD T18 vector. Positive clones were selected by double-restriction endonuclease digestion (EcoRⅠ and HindⅢ) and PCR. Twenty seven clones were randomly selected from an asymptomatic mother [at two time points: 602 (1 d) and 6022 (6 mo)] and her son [602 (S)], and the phylogenetic and mutational analysis was performed using BioEditor, Clustal X and MEGA software. Potential immune epitopes were determined by the Stabilized Matrix Method (SMM), SMM-Align Method and Emini Surface Accessibility Prediction. RESULTS: All of the 27 sequences were genotype C, the divergence between the mother and son was 0%-0.8%. Compared with another 50 complete sequences of genotype C, the mother and her son each had 13 specific nucleotides that differed from the other genotype C isolates. AA 1-11 deletion in preS1 was the dominant mutation in the mother (14/18). The 1762T/1764A double mutation existed in all clones of the mother, 3 of them were also coupled with G1896A mutation, but none were found in the son.17 bp deletion starting at nucleotide 2330 was the major mutation (5/9) in the son, which caused seven potential HLA class Ⅰ epitopes and one B cell epitope deletion, and produced a presumptive new start codon, downstream from the original one of the P gene. CONCLUSION: The HBV strain in the son came from his mother, and discrepant mutation occurred in the mother and her son during infection. 展开更多
关键词 Hepatic B virus Vertical transmission Fullgenome Mutation PHYLOGENETIC DELETION
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Effect of delivery mode on maternal-infant transmission of hepatitis B virus by immunoprophylaxis 被引量:23
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作者 王建设 朱启镕 张秀珍 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第10期1510-1512,共3页
OBJECTIVE: To study the effect of different delivery modes on immunoprophylaxis efficacy so as to clarify whether or not cesarean section reduces immunoprophylaxis failure. METHODS: Mothers with positive hepatitis B s... OBJECTIVE: To study the effect of different delivery modes on immunoprophylaxis efficacy so as to clarify whether or not cesarean section reduces immunoprophylaxis failure. METHODS: Mothers with positive hepatitis B surface antigen (HBsAg) were selected in the third trimester of pregnancy. Their babies were inoculated with hepatitis B immunoglobulin at birth and hepatitis B vaccine at 1, 2 and 7 months of age. HBsAg and its antibodies (anti-HBs) were tested at 1, 4, 7, and 12 months of age, then followed up yearly. RESULTS: A total of 301 babies entered the study, including 144 born by normal spontaneous vaginal delivery, 40 by obstetric forceps or vacuum extraction, and 117 by cesarean section. The incidence of mother's HBeAg positivity or baby's gender constitution was comparable between the three groups. There were no significant differences in the positive rate of anti-HBs or HBsAg at follow-up periods among the three groups. At 12 months of age, anti-HBs could be detected in 78.9% of the babies born by normal vaginal delivery, 84.6% of the babies by forceps or vacuum extraction, and 86.4% of the babies by cesarean section. The positive rate of HBsAg was 8.1%, 7.7%, 9.7%, and chronic HBV infection incidence was 7.3%, 7.7%, 6.8% respectively. CONCLUSIONS: There are no significant effects of delivery mode on the interruption of HBV maternal-baby transmission by immunoprophylaxis. Cesarean section does not reduce the incidence of immunoprophylaxis failure. 展开更多
关键词 Cesarean Section Disease Transmission Vertical Female Hepatitis B Hepatitis B Antibodies Hepatitis B Surface Antigens Hepatitis B Vaccines Humans IMMUNOGLOBULINS PREGNANCY
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Mechanism of peripheral blood mononuclear cell invasion by HBV on artificial immunization in newborns 被引量:4
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作者 岳亚飞 孟金来 张树林 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第9期1380-1382,153-154,共3页
OBJECTIVE: To study the effect and mechanism of the peripheral blood mononuclear cell (PBMC) invasion by HBV on artificial immunization in newborns. METHODS: Fifty-two newborns of HBsAg positive mothers were immunized... OBJECTIVE: To study the effect and mechanism of the peripheral blood mononuclear cell (PBMC) invasion by HBV on artificial immunization in newborns. METHODS: Fifty-two newborns of HBsAg positive mothers were immunized with HBIG (hepatitis B immunoglobulin) and HBVac (hepatitis B vaccine) and were followed up for 7 months. The newborns' HBV-DNA in serum and in the PBMCs was detected with nested-PCR; anti-HBs was tested with solid phase radioimmunoassay (SP-RIA). PBMCs isolated from newborn peripheral blood were incubated in the presence of PHA or purified HBsAg. Interleukin-2 (IL-2) level in culture supernatants of activated cells was detected by ELISA. RESULTS: The failure rate of immunization was higher in infants with positive HBV-DNA in PBMCs than those with negative HBV-DNA (P 展开更多
关键词 DNA Viral Hepatitis B Surface Antigens Hepatitis B Vaccines Hepatitis B virus Humans IMMUNIZATION IMMUNOGLOBULINS Infant Newborn INTERLEUKIN-2 Leukocytes Mononuclear
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Effect of delivery mode on maternal-infant transmission of hepatitis B virus by immunoprophylaxis
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作者 王建设 朱启镕 张秀珍 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第10期70-72,149-150,共5页
To study the effect of different delivery modes on immunoprophylaxis efficacy so as to clarify whether or not cesarean section reduces immunoprophylaxis failure Methods Mothers with positive hepatitis B surface ant... To study the effect of different delivery modes on immunoprophylaxis efficacy so as to clarify whether or not cesarean section reduces immunoprophylaxis failure Methods Mothers with positive hepatitis B surface antigen (HBsAg) were selected in the third trimester of pregnancy Their babies were inoculated with hepatitis B immunoglobulin at birth and hepatitis B vaccine at 1, 2 and 7 months of age HBsAg and its antibodies (anti HBs) were tested at 1, 4, 7, and 12 months of age, then followed up yearly Results A total of 301 babies entered the study, including 144 born by normal spontaneous vaginal delivery, 40 by obstetric forceps or vacuum extraction, and 117 by cesarean section The incidence of mother’s HBeAg positivity or baby’s gender constitution was comparable between the three groups There were no significant differences in the positive rate of anti HBs or HBsAg at follow up periods among the three groups At 12 months of age, anti HBs could be detected in 78 9% of the babies born by normal vaginal delivery, 84 6% of the babies by forceps or vacuum extraction, and 86 4% of the babies by cesarean section The positive rate of HBsAg was 8 1%, 7 7%, 9 7%, and chronic HBV infection incidence was 7 3%, 7 7%, 6 8% respectively Conclusions There are no significant effects of delivery mode on the interruption of HBV maternal baby transmission by immunoprophylaxis Cesarean section does not reduce the incidence of immunoprophylaxis failure 展开更多
关键词 vertical disease transmission · hepatitis B virus · cesarean section
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Management of chronic hepatitis B during pregnancy 被引量:1
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作者 Aysha Aslam Karen Joanie Campoverde Reyes +2 位作者 Vijayram Reddy Malladi Rizwan Ishtiaq Daryl T.Y.Lau 《Gastroenterology Report》 SCIE EI 2018年第4期257-262,I0001,共7页
Chronic hepatitis B is globally prevalent and is a major cause of cirrhosis and hepatocellular carcinoma.Despite immunoprophylaxis against hepatitis B in pregnancy,perinatal transmission still occurs in at least 10%of... Chronic hepatitis B is globally prevalent and is a major cause of cirrhosis and hepatocellular carcinoma.Despite immunoprophylaxis against hepatitis B in pregnancy,perinatal transmission still occurs in at least 10%of the children born to a mother with high level of viremia.Decisions regarding hepatitis B therapy during pregnancy must take into account the benefits and safety for both the mother and the unborn baby.In this review,we summarize the current treatment options for chronic hepatitis B with a focus on management during pregnancy and the evidence-based strategies to prevent vertical transmission of hepatitis B virus(HBV). 展开更多
关键词 Chronic hepatitis B PREGNANCY nucleoside analogue hepatitis B therapy
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