梅毒及性传播疾病和艾滋病高发原因探析

造成梅毒及性传播疾病(包括HIV)流行行为危险因素还广泛存在,积极、稳妥、持续、科学的疾病预防与控制及支持策略是临床工作顺利展开的可靠保障。应客观、科学看待和解决,制定切实可行的措施。

街区式商业办公设计思路研究——以世纪金花大明宫项目概念方案设计(二期)为例

文章通过二期开放式商业街区设计的深入研究,分析了其设计原则、空间布局、景观设计以及环境心理学应用等方面。研究表明,开放式商业街区设计应以人为本,注重多元化、开放性和互动性,同时充分利用景观设计提升空间品质,并关注环境心理学在设计中的应用。文章对位于古城西安开放式商业街区的设计进行深入研究,旨在创造一种既具有空间层次感又充满活力的商业空间。

面向Z世代,主流媒体如何重构内容生产与价值传播——以中央广播电视总台年轻态创新表达为例

随着新媒介技术的崛起,Z世代已然成为互联网时代视听文化产品的消费主力。主流价值观、抽象理论概念、中华优秀传统文化开始以更加国际化、年轻态的表达呈现,焕发出互联网时代的青春光彩。近年来,中央广播电视总台的年轻态转型创新,为主流媒体内容生产的年轻态表达开拓出新的路径。

编造、故意传播虚假信息罪中“严重扰乱社会秩序”认定问题研究

“严重扰乱社会秩序”作为编造、故意传播虚假信息罪构成要件中的危害结果,在没有出台相关司法解释的前提下认定界定存在模糊不清的情况,所以导致司法实践中存在同案不同判的情形。遂本文欲将整理总结近些年来我国以编造、故意传播虚假信息罪为案由的司法判例展开实证研究,并结合相关学说,对“严重扰乱社会秩序”进行解释。

Wireless location algorithm using digital broadcasting signals based on neural network

In order to enhance the accuracy and reliability of wireless location under non-line-of-sight （NLOS） environments,a novel neural network （NN） location approach using the digital broadcasting signals is presented. By the learning ability of the NN and the closely approximate unknown function to any degree of desired accuracy,the input-output mapping relationship between coordinates and the measurement data of time of arrival （TOA） and time difference of arrival （TDOA） is established. A real-time learning algorithm based on the extended Kalman filter （EKF） is used to train the multilayer perceptron （MLP） network by treating the linkweights of a network as the states of the nonlinear dynamic system. Since the EKF-based learning algorithm approximately gives the minimum variance estimate of the linkweights,the convergence is improved in comparison with the backwards error propagation （BP） algorithm. Numerical results illustrate thatthe proposedalgorithmcanachieve enhanced accuracy,and the performance ofthe algorithmis betterthanthat of the BP-based NN algorithm and the least squares （LS） algorithm in the NLOS environments. Moreover,this location method does not depend on a particular distribution of the NLOS error and does not need line-of-sight （ LOS ） or NLOS identification.

电视问政节目的组织与策划路径研究——以《请人民阅卷》为例

近年来,电视问政节目逐步兴起,成为视听传播领域的亮点节目,目的在于问计民生、管理政事。此类节目借助电视媒介,架起政府与公众之间的沟通桥梁,面对面沟通公共事务,创建协商机制,既符合受众需求、执政需要,又充分发挥了新闻媒体的功能和优势,实现了新闻与政治的有机结合,是新传播环境下传播能力提升的重要表现。

基于多阶邻居壳数的向量中心性度量方法

K-壳分解法在度量复杂网络中节点的重要性方面具有重要的理论意义和应用价值.但K-壳方法中,存在大量壳值相等的节点,从而无法精确地比较这些具有相同壳值节点的相对重要性.因此,本文基于网络中节点自身壳值与其多阶邻居的壳值,设计利用向量的形式来表示节点在复杂网络中的相对重要性程度,提出了多阶邻居壳数向量中心性方法,并设计了该中心性向量比较方法.通过在七个真实网络中进行消息传播与静态攻击实验,发现基于多阶邻居壳数向量的中心性方法具有计算复杂度低,能够有效发现具有高传播能力的节点,在传播实验中具有优越的性能.并在静态攻击实验过程中倾向于优先破坏网络中的传播核心结构.多阶邻居壳数向量中心性方法在保留K-壳中心性信息的前提下,极大提高了节点重要性的区别程度,平衡了对节点在复杂网络中联通结构的重要性的度量和对传播结构重要性的度量,因此具有重要理论意义与应用价值.

Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism

AIM: To explore the mechanism of intra-uterine transmission,the HBV infection status of placental tissue and in vitro cultured placental trophoblastic cells was tested through in vivo and in vitro experiments. METHODS: A variety of methods,such as ELISA,RT- PCR,IHC staining and immunofluorescent staining were employed to test the HBV marker positive pregnant women's placenta and in vitro cultured placental trophoblastic cells. RESULTS: The HBV DNA levels in pregnant women's serum and fetal cord blood were correlated. For those cord blood samples positive for HBV DNA,their maternal blood levels of HBV DNA were at a high level. The HBsAg IHC staining positive cells could be seen in the placental tissues and the presence of HBV DNA detected. After co-incubating the trophoblastic cells and HBV DNA positive serum in vitro,the expressions of both HBsAg and HBV DNA could be detected. CONCLUSION: The mechanism of HBV intra-uterine infection may be due to that HBV breaches the placental barrier and infects the fetus.

Fast direction of arrival algorithm based on vector-sensor arrays using wideband sources

An acoustic vector sensor(AVS)can capture more information than a conventional acoustic pressure sensor(APS).As a result,more output channels are required when multiple AVS are formed into arrays,making processing the data stream computationally intense.This paper proposes a new algorithm based on the propagator method for wideband coherent sources that eliminates eigen-decomposition in order to reduce the computational burden.Data from simulations and lake trials showed that the new algorithm is valid:it resolves coherent sources,breaks left/right ambiguity,and allows inter element spacing to exceed a half-wavelength.

Energy-Efficient Sensing and Transmission for Multi-Hop Relay Cognitive Radio Sensor Networks

How to achieve transmissions in an energy-efficient way in multi-hop decode and forward(DF) relay cognitive radio sensor networks(CRSNs) is important since sensor nodes in CRSNs are usually battery powered. This paper aims to maximize energy efficiency(EE) by joint optimizing sensing time and power allocation in multi-channels & multihops DF relay CRSNs under constraints on outage probability and sensing performance. First, we design a channel selection scheme for sensing according to the available probabilities of multi channels. Second, we analyze the expected throughput and energy consumption and formulate the EE problem as a concave/concave fractional program. Third, coordinate ascent and Charnes-Cooper Transformation(CCT) methods are used to transform the nonlinear fractional problem into an equivalent concave problem. Subsequently, the closed form of outage probability is derived and the convergence rate of the iterative algorithm is analyzed. Finally, simulation results show that the proposed scheme can achieve effective EE.

EXTENDED MONTE CARLO LOCALIZATION ALGORITHM FOR MOBILE SENSOR NETWORKS

A real-world localization system for wireless sensor networks that adapts for mobility and irregular radio propagation model is considered. The traditional range-based techniques and recent range-free localization schemes are not well competent for localization in mobile sensor networks, while the probabilistic approach of Bayesian filtering with particle-based density representations provides a comprehensive solution to such localization problem. Monte Carlo localization is a Bayesian filtering method that approximates the mobile node's location by a set of weighted particles. In this paper, an enhanced Monte Carlo localization algorithm-Extended Monte Carlo Localization (Ext-MCL) is proposed, i.e., the traditional Monte Carlo localization algorithm is improved and extended to make it suitable for the practical wireless network environment where the radio propagation model is irregular. Simulation results show the proposal gets better localization accuracy and higher localizable node number than previously proposed Monte Carlo localization schemes not only for ideal radio model, but also for irregular one.

Study on the blood-borne virus co-infection and T lymphocyte subset among intravenous drug users

AIM： To investigate the features of various blood- borne virus infections and co-infection in intravenous drug users （IDUs）, and to examine the correlation of T lymphocyte subsets with virus co-infection. METHODS： Four hundred and six IDUs without any clinical manifestation of hepatitis and 102 healthy persons were enrolled in this study. HBV-DNA and HCV-RNA were detected by fluorescence quantitative PCR. HBsAg, HBeAg, anti-HBc, anti-HCV, HDV-Ag, anti-HGV, anti-HIV, and HCMV-IgM were assayed by enzyme-linked immunosorbent assay （ELISA） and immunochromatographic tests. The levels of Th1 and Th2 cytokines were measured by ELISA and radioactive immune assay （RIA）. The T lymphocyte subpopulation was detected by using fluorescence immunoassay. The similar indices taken from the healthy persons served as controls. RESULTS： The viral infection rate among IDUs was 36.45% for HBV, 69.7% for HCV, 47.3% for HIV, 2.22% for HDV, 1.97% for HGV, and 3.45% for HCMV. The co- infection rate of blood-borne virus was detected in 255 of 406 （62.81%） IDUs. More than 80% （161/192） of subjects infected with HIV were co-infected with the other viruses, such as HBV, HCV. In contrast, among the controls, the infection rate was 17.65% for HBV and 0% for the other viruses. Our investigation showed that there was a profound decrease in the proportion of CD4/CD8 and the percentage of CD3 and CD4, but not in the percentage of CD8. The levels of PHA-induced cytokines （IFN-γ and IL-4） and serum IL-2 were obviously decreased in IDUs. On the other hand, the level of serum IL-4 was increased. The level of IFN-γ and the percentage of CD4 were continuously decreased when the IDUs were infected with HIV or HIV co-infection. IDUs with HIV and HBV co-infection was 15.1% （29/192）. Of those 29 IDU with HIV and HBV co-infection, 51.72% （15/29） and 37.93% （11/29） were HBV-DNA-positive and HBeAg-positive, respectively. But, among IDUs without HIV infection, only 1.68% （2/119） of cases were HBV- DNA-positive.CONCLUSION： HCV, HBV and HIV infections are common in this population of IDU, leading to a high incidence of impaired Thl cytokine levels and CD4 lymphocyte. IDUs with HIV and HBV/HCV co-infection have lower expression of Th1 cytokine with enhancement of the Th2 response. HIV may be causing HBV replication by decreasing Thl function.

Injection drug use and HIV/AIDS transmission in China

After nearly three decades of being virtually drug free, use of heroin and other illicit drugs has re-emerged in China as a major public health problem. One result is that drug abuse, particularly heroin injection, has come to play a predomi- nant role in fueling China’s AIDS epidemic. The first outbreak of HIV among China’s IDUs was reported in the border area of Yunnan province between China and Myanmar where drug trafficking is heavy. Since then drug-related HIV has spread to all 31 provinces, autonomous regions and municipalities. This paper provides an overview to HIV/AIDS transmission through injection drug use in China. It begins with a brief history of the illicit drug trade in China, followed by a discussion of the emergence of drug related AIDS, and a profile of drug users and their sexual partners who have contracted the virus or who are vulnerable to infection. It ends by summarizing three national strategies being used by China to address both drug use and AIDS as major health threats.

New Measuring Temperature Setup with Optical Probe

Abstract: A new setup of measuring temperature is developed, which the probe is a micro- power consumptive one with CMOS circuit and is driven by optical power. For transmitting the measured signal and optical power signal in a long distance, the fiber technology is applied in this setup.

PVC Membrane Selective Electrode for Determination of Cadmium(Ⅱ) Ion in Chocolate Samples

Benzil bis(carbohydrazone)(BBC) is prepared and explored as new N N Schiff's base, which plays the role of an excellent ion carrier in the construction of a Cd(II) ion membrane sensor. The tris(2-ethylhexyl) phosphate best performance corresponds to a membrane composition of 30% poly(vinyl chloride), 65%(TEHP), 3.5% BBC and 1.5% tetradodecyl-ammoniumtetrakis(4-chlorophenyl) borate(ETH 500). This sensor shows very good selectivity and sensitivity towards cadmium ion over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The effect of membrane composition, selectivity, pH and influence of additive on the response properties of electrode were investigated. The response mechanism was discussed in the view of UV-spectroscopy. The electrode exhibits a Nernstian behavior(with slope of 29.7 mV per decade) over a very wide concentration range from 1.0×10?1 to 1.0×10?8 mol·L?1 with a detection limit of 3.2×10?8 mol·L?1. It shows rela-tively fast response time in whole concentration range(<8 s) and can be used for at least 10 weeks in the pH range of 2.0-9.0. The proposed sensor is successfully used for the determination of cadmium in different chocolate sam-ples and as indicator electrode in titration with ethylene diamine tetraacetate(EDTA).

An improved multidirectional velocity model for micro-seismic monitoring in rock engineering

An improved multidirectional velocity model was proposed for more accurately locating micro-seismic events in rock engineering. It was assumed that the stress wave propagation velocities from a micro-seismic source to three nearest monitoring sensors in a sensor's array arrangement were the same. Since the defined objective function does not require pre-measurement of the stress wave propagation velocity in the field, errors from the velocity measurement can be avoided in comparison to three traditional velocity models. By analyzing 24 different cases, the proposed multidirectional velocity model iterated by the Simplex method is found to be the best option no matter the source is within the region of the sensor's array or not. The proposed model and the adopted iterative algorithm are verified by field data and it is concluded that it can significantly reduce the error of the estimated source location.

Biovars and Serotypes of Ureaplasma Urealyticum among Chinese Women Undergoing Routine Gynecologic Exam, Women with Sexually Transmitted Infections, and Female Sex Workers

Objectives: To characterize the distribution pattern of biovars and scrotypes or Ureaplasma urealyyicum in normalhealthy women, sexually transmitted infections clinic clients,and in sex workers. Methods: We cultured cervical swabs taken from 261physical check-up clients, 599 STI clinic outpatients and 98 sexworkers using commercial selective medium. Some positivecultures were further biotyped and serotyped by PCR. Results: (1) U. urealyticum is more commonly isolated in sexworkers (90.8%) than in the physical check-up group (60.9%)or the STI outpatient group (61.3%) (P<0.001). (2) Biovar 1of U. 'realyticum (95.0%), especially single infection ofserotype 1. 3, and 6 of biovar 1, is commonly found in healthywomen. (3) Biovar 2 infection of U urealyticum is moreprevalent in sex workers (28.1%) and STI outpatients group(26.6%) than that in the physical check-up group (4.9%) (P<0.001). (4) Mixed infection caused by more than one serotypeof U urealyticum increased from physical check-up group(8.6%) to STI utpatients (12.4%) to sex workers (23.9%) (P<0.01). (5) There is no statistically significant difference in thedistribution of serotype 1, 3, and 6 of biovar 1 among thesethree groups (P=0.763). (6) The PCR method described here isrelatively simple, rapid and specific for the biotyping andserotyping of biovar 1 of U urealyticum. Conclusion: We should pay more attention to biovar 2 andmixed infections of U. urealyticum than single infection ofhiovar 1 in clinic practice. PCR is a good method for biotypingand serotvping.

Asymptomatic Herpes Simplex Virus Shedding in STI Patients

Objective: This study examined Herpes Simplex Virus (HSV) subclinical shedding in the genital tract of patients withgenital herpes (GH) or non-gonoccal urethritis (NGU). Method Swabs were collected after exposure to rash andgenital tract during GH relapse or remission on a weekly basisfor four to six weeks. NGU patients with negative chlamydiaand mycoplasma tests were also swabbed for a similarduration. All swabs underwent HSV DNA detection withquantitative PCR. Result: There was a significant difference in the rate ofasymptomatic HSV shedding in urinary tracts comparing GHand the control group and comparing NGU and the controlgroup (P<0.05). The rate of HSV shedding was 22%, 9.8%and 3.3% for GH, NGU and control groups respectively. Therate of HSV shedding was 21.7% (20/92) for patients withactive GH and 23% for those in remission. The HSV positiverate was significantly higher in the group with patients whohad more than six relapses within one year compared to thegroup of patients with less than six relapses.Conclusion: There is HSV subclinical shedding in theirgenital tract during active GH and remission. SubclinicalHSV shedding is more common in patients with more than sixGH relapses per year compared to GH patients with fewerrelapses. Approximately 9.9% of NGU patients with negativechlamydia mycoplasma testing was found to have subclinicalHSV infection.

Investigation on Biovars and Serotypes of Ureaplasma Urealyticum in Cervix in Chinese Gynecologic Check-up Population, Sexually Transmitted Infections Clinic Clients and Sex Workers

Objectives: To characterize the distribution pattern biovars and serotypes of Ureaplasma urealyticum in normahealthy women, sexually transmitted infections clinic clienand in sex workers. Methods: We cultured cervical swabs taken from 26physical check-up clients, 599 STI clinic outpatients and 9sex workers using commercial selective medium. Sompositive cultures were further biotyped and serotyped bPCR. Results: (1) Biovar 1 of U urealyticum (95.0%), especiallsingle infection of serotype 1, 3, and 6 of biovar 1,commonly found in healthy women. (2) U urealyticummore commonly isolated in sex workers (90.8%) than iphysical check-up group (60.9%) and STI outpatients grou(61.3%) (P<0.001). (3) Biovar 2 infection of U urealyticuris more prevalent in sex workers (28.1%) and SToutpatients group (26.6%) than that in physical check-ugroup (4.9%) (P<0.001). (4) Mixed infection caused bmore than one serotype of U. urealyticum is increasing fromphysical check-up group (8.6%) to STI outpatients (12.4%and to sex wokers (23.9%) (P<0.01). (5) There is nstatistic difference in the distribution of serotype 1, 3, and of biovar 1 among these three groups (P=0.763). (6) ThPCR method described here is relatively simple, rapid anspecific for the biotyping and serotyping of biovar 1 of Uurealyticum. Conclusion: we should pay more attention to biovarand mixed infection than single infection of biovar 1 of Uurealyticum in clinic practice. PCR is a good method ibiotyping and serotyping.

Partner's Sexual Behaviora are an Important Risk Factor for Chlamydia Trachomatis Infection among STD Patients

Risk factors for genitourinary Chlamydia trachomatis (Ct) infection were investigated using an STD elative risk factor questionnaire among 176 patients and theirregular sexual partners. Twenty-four independent variableswere selected for analysis, nine of which were confirmed asfactors associated with C. trachomatis. Four of the nine factorswere significantly correlated to infection using a multifactorialunconditional logistic regression model which included: levelof education (odds ratios [ORs]: 2.144 for below junior middleschool), number of sexual partners (ORs: 4.503 for≥5),number of regular partner's sexual partner (ORs: 16.333 for≥5), STD history of regular partner (ORs: 18.417 for theirSTD history). These data demonstrate that regular partner'ssexual behaviors are also an important risk factor for Ctinfection among STD clinic clients.