Objective： To investigate the neuroprotective effect of Bu-Shen-Huo-Xue （BSHX） extract, a polyherbal formula, against High Glucose （HG）-induced neurotoxicity in PC12 cells. Methods： Cell viability assay, Lactate...Objective： To investigate the neuroprotective effect of Bu-Shen-Huo-Xue （BSHX） extract, a polyherbal formula, against High Glucose （HG）-induced neurotoxicity in PC12 cells. Methods： Cell viability assay, Lactate Dehydrogenase （LDH） assay, Reactive Oxygen Species （ROS） detection, Hoechst 33258, Acridine Orange （AO）/Ethidium Bromide （EB） double stain and Mitochondrial Membrane Potential （MMP） assay were performed. In addition, Bax, Bcl-2, caspase-3, cleaved caspase-3, PARP, cleaved PARP, cytochrome c and Mitogen-Activated Protein Kinases （MAPKs） were detected by western blot. Results： BSHX extract increased cell viability and decreased LDH leakage in a concentration-dependent manner in HG-induced PC12 cells. Moreover, BSHX extract decreased the level of intracellular ROS, increased mitochondrial membrane potential, regulated the expressions of Bax and Bcl-2, and inhibited the release of cytochrome c from mitochondria. Furthermore, BSHX extract attenuated the activation of caspase-3 and PARP, and inhibited the phosphorylations of c-Jun N-terminal kinase （JNK） and p38 MAPKs. Conclusion： BSHX extract exhibited significant neuroprotective effect on HG-induced apoptosis in PC12 cells. This effect may be associated with the suppression of ROS generation as well as mitochondria-mediated caspase and JNK/p38 MAPK signaling pathways.展开更多
This paper discusses some of the conventional accounting concepts, such as historical cost concept, conservatism concept, matching concept, objectivity concept, stable monetary unit assumption, and going-concern assum...This paper discusses some of the conventional accounting concepts, such as historical cost concept, conservatism concept, matching concept, objectivity concept, stable monetary unit assumption, and going-concern assumption, which are not in accordance with the Islamic accounting paradigm due to their divergence with some verses of the Holy AI-Qur＇an, the Hadiths of the Prophet Muhammad, peace be upon him （pbuh）, and the basic of Zakat calculation. This is a conceptual paper describing some of the conventional accounting concepts that are not in accordance with the paradigm of Islamic accounting. The paper concludes that the historical cost concept can be replaced by： current cash equivalent concept, historical cost and current value concepts （market selling price）, current cost concept, historical cost concept in all （except for Zakat purposes） accounting calculations, current valuation concept, and fair value concept. Conservatism concept must be eliminated if historical cost concept is not used anymore. Matching concept can be replaced by asset-liability approach concept. Objectivity concept can be replaced by Zakat accountability concept. Stability of the monetary unit assumption can be replaced by gold or silver measurement, or Dirham currency, and going-concern assumption must be eliminated.展开更多
The economic viability and social value of traditional aquaculture in rural Sierra Leone were evaluated. The hypothesis tested was that traditional methods of farming fish in ponds were not economically viable, so far...The economic viability and social value of traditional aquaculture in rural Sierra Leone were evaluated. The hypothesis tested was that traditional methods of farming fish in ponds were not economically viable, so farmers were investing their time/labour in less risky and more profitable livelihoods activities. The assumption in this assessment was that fish farming is an economic activity, and that for farmers to adopt or choose it over other livelihoods, the benefit-cost ratio of fish farming must be higher than that of alternative livelihoods. The main objective of the study was to assess why local farmers failed to adopt modem market oriented aquaculture production systems introduced by the Ministry of Fisheries and Marine Resources in rural Sierra Leone. Two hundred farmers owning fishponds on family lands were interviewed using semi-structured questionnaires and farmers＇ responses were analyzed using statistical tools （SPSS 16.0）. The mean contributions of different livelihoods to total annual incomes of farmers and the social values they attached to these livelihoods were compared. Results of the study suggested that traditional fish fanning was economically viable across the range of pond sizes sampled; but the medium-sized ponds were more profitable than the smallest and largest ponds, and labour accounted for 70% of total annual production costs in the systems assessed. The average benefit-cost ratio of 2.3 for fish fanning was favorable compared with that of 0.83 for rice farming, which was ranked as most popular livelihood activity by farmers. The payback period for traditional aquaculture investments was less than five years using informal investment loans （without interest）, and was favorably compared with that for tree crops fanning, which was also popular among farmers. Additional benefits of fish fanning included social capital and maintenance of kinship relationships.展开更多
The integration of global economic and society information makes the traditional education and means of education have been changing for thousands of years, which never appear before. The internationalization of highe...The integration of global economic and society information makes the traditional education and means of education have been changing for thousands of years, which never appear before. The internationalization of higher education has become the true fact. The non-governmental colleges has become the important part of higher education as a new power and abiding by the trend of internationalization of higher education just like the public colleges. Therefore they need to enhance the cultural exchange and cooperation with international universities and orientate their talent training mode in the international competition and even take the charge of flexible operation mechanism to pave the new way for their own characteristics and core competence.展开更多
基金This work was supported by the National Natural Science Foundation of China （Grant Nos. 81530099, 81573763 and 81773932）, the Beijing Municipal Natural Science Foundation （Grant No.7172221）, and the National Key Technology R＆D Program ＂New Drug Innovation＂ of China （Grant No. 2016YFE0116200）.
文摘Objective： To investigate the neuroprotective effect of Bu-Shen-Huo-Xue （BSHX） extract, a polyherbal formula, against High Glucose （HG）-induced neurotoxicity in PC12 cells. Methods： Cell viability assay, Lactate Dehydrogenase （LDH） assay, Reactive Oxygen Species （ROS） detection, Hoechst 33258, Acridine Orange （AO）/Ethidium Bromide （EB） double stain and Mitochondrial Membrane Potential （MMP） assay were performed. In addition, Bax, Bcl-2, caspase-3, cleaved caspase-3, PARP, cleaved PARP, cytochrome c and Mitogen-Activated Protein Kinases （MAPKs） were detected by western blot. Results： BSHX extract increased cell viability and decreased LDH leakage in a concentration-dependent manner in HG-induced PC12 cells. Moreover, BSHX extract decreased the level of intracellular ROS, increased mitochondrial membrane potential, regulated the expressions of Bax and Bcl-2, and inhibited the release of cytochrome c from mitochondria. Furthermore, BSHX extract attenuated the activation of caspase-3 and PARP, and inhibited the phosphorylations of c-Jun N-terminal kinase （JNK） and p38 MAPKs. Conclusion： BSHX extract exhibited significant neuroprotective effect on HG-induced apoptosis in PC12 cells. This effect may be associated with the suppression of ROS generation as well as mitochondria-mediated caspase and JNK/p38 MAPK signaling pathways.
文摘This paper discusses some of the conventional accounting concepts, such as historical cost concept, conservatism concept, matching concept, objectivity concept, stable monetary unit assumption, and going-concern assumption, which are not in accordance with the Islamic accounting paradigm due to their divergence with some verses of the Holy AI-Qur＇an, the Hadiths of the Prophet Muhammad, peace be upon him （pbuh）, and the basic of Zakat calculation. This is a conceptual paper describing some of the conventional accounting concepts that are not in accordance with the paradigm of Islamic accounting. The paper concludes that the historical cost concept can be replaced by： current cash equivalent concept, historical cost and current value concepts （market selling price）, current cost concept, historical cost concept in all （except for Zakat purposes） accounting calculations, current valuation concept, and fair value concept. Conservatism concept must be eliminated if historical cost concept is not used anymore. Matching concept can be replaced by asset-liability approach concept. Objectivity concept can be replaced by Zakat accountability concept. Stability of the monetary unit assumption can be replaced by gold or silver measurement, or Dirham currency, and going-concern assumption must be eliminated.
文摘The economic viability and social value of traditional aquaculture in rural Sierra Leone were evaluated. The hypothesis tested was that traditional methods of farming fish in ponds were not economically viable, so farmers were investing their time/labour in less risky and more profitable livelihoods activities. The assumption in this assessment was that fish farming is an economic activity, and that for farmers to adopt or choose it over other livelihoods, the benefit-cost ratio of fish farming must be higher than that of alternative livelihoods. The main objective of the study was to assess why local farmers failed to adopt modem market oriented aquaculture production systems introduced by the Ministry of Fisheries and Marine Resources in rural Sierra Leone. Two hundred farmers owning fishponds on family lands were interviewed using semi-structured questionnaires and farmers＇ responses were analyzed using statistical tools （SPSS 16.0）. The mean contributions of different livelihoods to total annual incomes of farmers and the social values they attached to these livelihoods were compared. Results of the study suggested that traditional fish fanning was economically viable across the range of pond sizes sampled; but the medium-sized ponds were more profitable than the smallest and largest ponds, and labour accounted for 70% of total annual production costs in the systems assessed. The average benefit-cost ratio of 2.3 for fish fanning was favorable compared with that of 0.83 for rice farming, which was ranked as most popular livelihood activity by farmers. The payback period for traditional aquaculture investments was less than five years using informal investment loans （without interest）, and was favorably compared with that for tree crops fanning, which was also popular among farmers. Additional benefits of fish fanning included social capital and maintenance of kinship relationships.
文摘The integration of global economic and society information makes the traditional education and means of education have been changing for thousands of years, which never appear before. The internationalization of higher education has become the true fact. The non-governmental colleges has become the important part of higher education as a new power and abiding by the trend of internationalization of higher education just like the public colleges. Therefore they need to enhance the cultural exchange and cooperation with international universities and orientate their talent training mode in the international competition and even take the charge of flexible operation mechanism to pave the new way for their own characteristics and core competence.
