OTN（光传送网，Optical Transport Network），是以波分复用技术为基础、在光层组织网络的传送网，是下一代的骨干传送网。OTN通过G．872、G．709、G.798等一系列ITU-T的建议所规范的新一代“数字传送体系”和“光传送体系”。OTN将解...OTN（光传送网，Optical Transport Network），是以波分复用技术为基础、在光层组织网络的传送网，是下一代的骨干传送网。OTN通过G．872、G．709、G.798等一系列ITU-T的建议所规范的新一代“数字传送体系”和“光传送体系”。OTN将解决传统WDM网络无波长／子波长业务调度能力、组网能力弱、保护能力弱等问题。展开更多
Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-...Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-like nanocarrier by using the coarse grained model-based density functional theory, which combines a modified fundamental measure theory for the excluded-volume effects, Wertheim's first-order thermodynamics perturbation theory for the chain connectivity and the mean field approximation for van der Waals attraction. For comparison, the monomer nanocarrier TDD system and the no nanocarrier one are also investigated. The results indicate that the drug delivery capacity of rod-like nanocarriers is about 62 times that of the no nanocarrier one, and about 6 times that of the monomer nanocarriers. The reason is that the rod-like nanocarriers would self-assemble into the smectic phase perpendicular to the membrane surface. It is the self-assembly of the rod-like nanocarriers that yields the driving force for the targeted delivery of drugs inside the cell membrane. By contrast, the conventional monomer nanocarrier drug delivery system lacks the driving force to deliver the drugs into the cell membrane. In short, the novel rod-like nanocarrier TDD system may improve the drug delivery efficiency. Although the model in this work is simple, it is expected that the system may provide a new perspective for cancer targeted therapy.展开更多
文摘OTN（光传送网，Optical Transport Network），是以波分复用技术为基础、在光层组织网络的传送网，是下一代的骨干传送网。OTN通过G．872、G．709、G.798等一系列ITU-T的建议所规范的新一代“数字传送体系”和“光传送体系”。OTN将解决传统WDM网络无波长／子波长业务调度能力、组网能力弱、保护能力弱等问题。
基金supported by the National Natural Science Foundation of China (20874005, 20736002, 20821004)the National Basic Research Program of China (2011CB706900)+1 种基金Huo Yingdong Fundamental Research Foundation (121070)Novel Team (IRT0807) from Ministry of Education and the Chemical Grid Project of BUCT
文摘Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-like nanocarrier by using the coarse grained model-based density functional theory, which combines a modified fundamental measure theory for the excluded-volume effects, Wertheim's first-order thermodynamics perturbation theory for the chain connectivity and the mean field approximation for van der Waals attraction. For comparison, the monomer nanocarrier TDD system and the no nanocarrier one are also investigated. The results indicate that the drug delivery capacity of rod-like nanocarriers is about 62 times that of the no nanocarrier one, and about 6 times that of the monomer nanocarriers. The reason is that the rod-like nanocarriers would self-assemble into the smectic phase perpendicular to the membrane surface. It is the self-assembly of the rod-like nanocarriers that yields the driving force for the targeted delivery of drugs inside the cell membrane. By contrast, the conventional monomer nanocarrier drug delivery system lacks the driving force to deliver the drugs into the cell membrane. In short, the novel rod-like nanocarrier TDD system may improve the drug delivery efficiency. Although the model in this work is simple, it is expected that the system may provide a new perspective for cancer targeted therapy.
