AIM： To explore the expression and correlation of CD44v6, vascular endothelial growth factor （VEGF）, matrix metalloproteinase （MMP）-2 and matrix metalloproteinase （MMP）-9 in Krukenberg and primary epithelial ov...AIM： To explore the expression and correlation of CD44v6, vascular endothelial growth factor （VEGF）, matrix metalloproteinase （MMP）-2 and matrix metalloproteinase （MMP）-9 in Krukenberg and primary epithelial ovarian carcinoma. METHODS： The expressions of CD44v6, VEGF, MMP-2 and MMP-9 were detected by immunohistochemical method in 20 cases of normal ovarian tissues, 38 cases of Krukenberg tumor and 45 cases of primary epithelial ovarian carcinoma. RESULTS： The expression of CD44v6 （primary epithelial ovarian carcinoma tissue vs normal ovarian tissue： χ^2= 4.516, P= 0.034; Krukenberg tumor tissue vsnormal ovarian tissue： χ^2 = 19.537, P = 0.001） and VEGF （primary epithelial ovarian carcinoma tissue vs normal ovarian tissue： P = 0.026; Krukenberg tumor tissue vs normal ovarian tissue： χ^2 = 22.895, P = 0.001） was significantly higher in primary epithelial ovarian carcinoma tissue and Krukenberg tumor tissue than in normal ovarian tissue. The positive expression rate of MMP-2 and MMP-9 was 0% in the normal ovarian tissue. The positive expression rate of CD44v6 （ χ^2= 10.398, P= 0.001）, VEGF （ χ^2= 13.149, P = 0.001）, MMP-2 （ χ^2 = 33.668, P = 0.001） and MMP-9 （ χ^2= 38.839, P = 0.001） was remarkably higher in Krukenberg tumor than in primary epithelial ovarian carcinoma. The correlation of CD44v6, VEGF, MMP-2, and MMP-9 was observed in primary epithelial ovarian carcinoma and Krukenberg tumor. CONCLUSION： CD44v6, VEGF, MMP-2, and MMP-9 are involved in ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6, VEGF, MMP-2 and MMP-9 may contribute to the diagnosis of ovarian carcinoma, gastric cancer, and Krukenberg tumor.展开更多
Georgian historiography dates the reign of King Vakhtang Gorgasali （Gorg-a-sar--＇wolf-head＇ in Persian） to the 2nd half of 5th century. The king is considered to have died in 502 in a fight with Persians. Cyril To...Georgian historiography dates the reign of King Vakhtang Gorgasali （Gorg-a-sar--＇wolf-head＇ in Persian） to the 2nd half of 5th century. The king is considered to have died in 502 in a fight with Persians. Cyril Toumanoff has expressed an opinion about the identification of Vakhtang Gorgasali with the King of Kartli Gurgen, mentioned by Procopius of Caesarea in 523. Accordingly, he believed that in case of such an identification, Vakhtang Gorgasali should have died in 527 during the big Persian invasion of Georgia. We have noticed that the author of the martyrdom of David and Constantine, who were based on the ancient chronicle （＂Dzveli Utskebani＂---Old Story） and who created his hagiographic work in the middle of 1 lth century, made a big mistake： erroneously, due to the similarity of names, he identified the sons of Georgian King Vakhtang Gorgasali Darchil and Mihrdat and the invasion of Persians in their reign with the sons of the ruler of Georgia （Kartli） Stephanoz III Mihrdat and Archil and invasions of Arabs and Marwan ibn Muhammad （Murvan Qru--＂Marwan the Deaf＇） that took place two centuries later, in the 30s of 8th century. Consequently, the author related the martyrdom on the background of Arab invasions. The fact that according to the author of the martyrdom, the sons of Vakhtang Gorgasali were in West Georgia, namely Anakopia, and fought the so-called Arabs there, makes it clear that the historical developments were taking place in the period of the Great Persian-Byzantine War of 542-562. In the title of the work it is mentioned that the invasion, during which the martyrdom of David and Constantine took place, happened in the vicinity of the death of Vakhtang Gorgasali. Thus, it becomes clear that King Vakhtang Gorgasali could not have died during the Persian-Byzantine War of 502-505 and that the Great Invasion of Persians described in the ＂Georgian Chronicles＂, in which Vakhtang Gorgasali was wounded, could only have happened in 527. The king must have died during a war between Persia and Byzantium in 527-532, more specifically in 527 when Persians invaded Georgia. Proceeding from the above, the surmise of Cyril Toumanoff regarding the death of Vakhtang Gorgasali in 527 becomes more convincing and well-grounded. Since it is known that King Vakhtang Gorgasali lived 60 years, the date of his birth can be presumed to be 466-467. This gives us an opportunity to establish a more precise date of reign ofVakhtang＇s father-Mihrdat and his grandfather-Archil. The dates of reign we have put forward for kings Mihrdat and Archil （Archil ,130-463, Mihrdat--463-473） correspond to the information of the Assyrian version of the Life of Peter the Iberian.展开更多
基金Supported by Foundation for Scholars Abroad of Ministry of Education of China, No. [2003]406Foundation of Heilongjiang Office of Education, No. 9551138
文摘AIM： To explore the expression and correlation of CD44v6, vascular endothelial growth factor （VEGF）, matrix metalloproteinase （MMP）-2 and matrix metalloproteinase （MMP）-9 in Krukenberg and primary epithelial ovarian carcinoma. METHODS： The expressions of CD44v6, VEGF, MMP-2 and MMP-9 were detected by immunohistochemical method in 20 cases of normal ovarian tissues, 38 cases of Krukenberg tumor and 45 cases of primary epithelial ovarian carcinoma. RESULTS： The expression of CD44v6 （primary epithelial ovarian carcinoma tissue vs normal ovarian tissue： χ^2= 4.516, P= 0.034; Krukenberg tumor tissue vsnormal ovarian tissue： χ^2 = 19.537, P = 0.001） and VEGF （primary epithelial ovarian carcinoma tissue vs normal ovarian tissue： P = 0.026; Krukenberg tumor tissue vs normal ovarian tissue： χ^2 = 22.895, P = 0.001） was significantly higher in primary epithelial ovarian carcinoma tissue and Krukenberg tumor tissue than in normal ovarian tissue. The positive expression rate of MMP-2 and MMP-9 was 0% in the normal ovarian tissue. The positive expression rate of CD44v6 （ χ^2= 10.398, P= 0.001）, VEGF （ χ^2= 13.149, P = 0.001）, MMP-2 （ χ^2 = 33.668, P = 0.001） and MMP-9 （ χ^2= 38.839, P = 0.001） was remarkably higher in Krukenberg tumor than in primary epithelial ovarian carcinoma. The correlation of CD44v6, VEGF, MMP-2, and MMP-9 was observed in primary epithelial ovarian carcinoma and Krukenberg tumor. CONCLUSION： CD44v6, VEGF, MMP-2, and MMP-9 are involved in ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6, VEGF, MMP-2 and MMP-9 may contribute to the diagnosis of ovarian carcinoma, gastric cancer, and Krukenberg tumor.
文摘Georgian historiography dates the reign of King Vakhtang Gorgasali （Gorg-a-sar--＇wolf-head＇ in Persian） to the 2nd half of 5th century. The king is considered to have died in 502 in a fight with Persians. Cyril Toumanoff has expressed an opinion about the identification of Vakhtang Gorgasali with the King of Kartli Gurgen, mentioned by Procopius of Caesarea in 523. Accordingly, he believed that in case of such an identification, Vakhtang Gorgasali should have died in 527 during the big Persian invasion of Georgia. We have noticed that the author of the martyrdom of David and Constantine, who were based on the ancient chronicle （＂Dzveli Utskebani＂---Old Story） and who created his hagiographic work in the middle of 1 lth century, made a big mistake： erroneously, due to the similarity of names, he identified the sons of Georgian King Vakhtang Gorgasali Darchil and Mihrdat and the invasion of Persians in their reign with the sons of the ruler of Georgia （Kartli） Stephanoz III Mihrdat and Archil and invasions of Arabs and Marwan ibn Muhammad （Murvan Qru--＂Marwan the Deaf＇） that took place two centuries later, in the 30s of 8th century. Consequently, the author related the martyrdom on the background of Arab invasions. The fact that according to the author of the martyrdom, the sons of Vakhtang Gorgasali were in West Georgia, namely Anakopia, and fought the so-called Arabs there, makes it clear that the historical developments were taking place in the period of the Great Persian-Byzantine War of 542-562. In the title of the work it is mentioned that the invasion, during which the martyrdom of David and Constantine took place, happened in the vicinity of the death of Vakhtang Gorgasali. Thus, it becomes clear that King Vakhtang Gorgasali could not have died during the Persian-Byzantine War of 502-505 and that the Great Invasion of Persians described in the ＂Georgian Chronicles＂, in which Vakhtang Gorgasali was wounded, could only have happened in 527. The king must have died during a war between Persia and Byzantium in 527-532, more specifically in 527 when Persians invaded Georgia. Proceeding from the above, the surmise of Cyril Toumanoff regarding the death of Vakhtang Gorgasali in 527 becomes more convincing and well-grounded. Since it is known that King Vakhtang Gorgasali lived 60 years, the date of his birth can be presumed to be 466-467. This gives us an opportunity to establish a more precise date of reign ofVakhtang＇s father-Mihrdat and his grandfather-Archil. The dates of reign we have put forward for kings Mihrdat and Archil （Archil ,130-463, Mihrdat--463-473） correspond to the information of the Assyrian version of the Life of Peter the Iberian.
