It has long been thought that bioprocess, with their inherent measurement difficulties and complex dynamics, posed almost insurmountable problems to engineers. A novel software sensor is proposed to make more effectiv...It has long been thought that bioprocess, with their inherent measurement difficulties and complex dynamics, posed almost insurmountable problems to engineers. A novel software sensor is proposed to make more effective use of those meas- urements that are already available, which enable improvement in fermentation process control. The proposed method is based on mixtures of Gaussian processes (GP) with expectation maximization (EM) algorithm employed for parameter estimation of mixture of models. The mixture model can alleviate computational complexity of GP and also accord with changes of operating condition in fermentation processes, i.e., it would certainly be able to examine what types of process-knowledge would be most relevant for local models’ specific operating points of the process and then combine them into a global one. Demonstrated by on-line estimate of yeast concentration in fermentation industry as an example, it is shown that soft sensor based state estimation is a powerful technique for both enhancing automatic control performance of biological systems and implementing on-line moni- toring and optimization.展开更多
In order to reduce the computation of complex problems, a new surrogate-assisted estimation of distribution algorithm with Gaussian process was proposed. Coevolution was used in dual populations which evolved in paral...In order to reduce the computation of complex problems, a new surrogate-assisted estimation of distribution algorithm with Gaussian process was proposed. Coevolution was used in dual populations which evolved in parallel. The search space was projected into multiple subspaces and searched by sub-populations. Also, the whole space was exploited by the other population which exchanges information with the sub-populations. In order to make the evolutionary course efficient, multivariate Gaussian model and Gaussian mixture model were used in both populations separately to estimate the distribution of individuals and reproduce new generations. For the surrogate model, Gaussian process was combined with the algorithm which predicted variance of the predictions. The results on six benchmark functions show that the new algorithm performs better than other surrogate-model based algorithms and the computation complexity is only 10% of the original estimation of distribution algorithm.展开更多
基金Project (No. 2002AA412010) supported by the National High-TechResearch and Development Program (863) of China
文摘It has long been thought that bioprocess, with their inherent measurement difficulties and complex dynamics, posed almost insurmountable problems to engineers. A novel software sensor is proposed to make more effective use of those meas- urements that are already available, which enable improvement in fermentation process control. The proposed method is based on mixtures of Gaussian processes (GP) with expectation maximization (EM) algorithm employed for parameter estimation of mixture of models. The mixture model can alleviate computational complexity of GP and also accord with changes of operating condition in fermentation processes, i.e., it would certainly be able to examine what types of process-knowledge would be most relevant for local models’ specific operating points of the process and then combine them into a global one. Demonstrated by on-line estimate of yeast concentration in fermentation industry as an example, it is shown that soft sensor based state estimation is a powerful technique for both enhancing automatic control performance of biological systems and implementing on-line moni- toring and optimization.
基金Project(2009CB320603)supported by the National Basic Research Program of ChinaProject(IRT0712)supported by Program for Changjiang Scholars and Innovative Research Team in University+1 种基金Project(B504)supported by the Shanghai Leading Academic Discipline ProgramProject(61174118)supported by the National Natural Science Foundation of China
文摘In order to reduce the computation of complex problems, a new surrogate-assisted estimation of distribution algorithm with Gaussian process was proposed. Coevolution was used in dual populations which evolved in parallel. The search space was projected into multiple subspaces and searched by sub-populations. Also, the whole space was exploited by the other population which exchanges information with the sub-populations. In order to make the evolutionary course efficient, multivariate Gaussian model and Gaussian mixture model were used in both populations separately to estimate the distribution of individuals and reproduce new generations. For the surrogate model, Gaussian process was combined with the algorithm which predicted variance of the predictions. The results on six benchmark functions show that the new algorithm performs better than other surrogate-model based algorithms and the computation complexity is only 10% of the original estimation of distribution algorithm.
