Drug rash with eosinophilia and systemic symptoms (DRESS)-is characterized by fever, rash and internal organ involvement after exposure to certain drugs. Most of the aromatic anticonvulsants, such as phenytoin, phenob...Drug rash with eosinophilia and systemic symptoms (DRESS)-is characterized by fever, rash and internal organ involvement after exposure to certain drugs. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Cross-sensitivity between not only the aromatic anticonvulsants, but also the aromatic and non-aromatic anticonvulsants, is possible. We report here a case of a Korean woman who had previously tolerated valproate, but developed DRESS due to valproate after carbamazepine intake, which indicates cross-sensitivity. Her skin lesions displayed diffuse oedematous patches on the entire body associated with tense bullae on her arms and legs. Circulating auto-antibody to 190- kDa antigen was detected in the patient’ s serum by indirect immunofluorescence and immunoblotting, which might contribute to a pathogenic role in DRESS.展开更多
重型药疹主要包括Stevens-Johnson综合征（重症型多形红斑．SJS）和中毒性表皮松解坏死症（TEN）、高敏综合征（Hypersensitivity Syndrome，HSS）又称伴嗜酸性粒细胞增多和系统症状的药物性发疹（Drug Rash with Eosinophilia and Syst...重型药疹主要包括Stevens-Johnson综合征（重症型多形红斑．SJS）和中毒性表皮松解坏死症（TEN）、高敏综合征（Hypersensitivity Syndrome，HSS）又称伴嗜酸性粒细胞增多和系统症状的药物性发疹（Drug Rash with Eosinophilia and Systemic Symptoms，DRESS）。这些重型药疹的共同特点是发病急，多器官受累，治疗过程中易有反复，并发症多，死亡率高。展开更多
药物疹伴嗜酸性粒细胞增多和系统症状（drug reaction with eosinophilia and systemic symptoms，DRESS），又称药物超敏反应综合征（drug hypersensitivity syndrom，DIHS）是一种具有特异症候的重症药疹，致死率大约为10％。2006年2...药物疹伴嗜酸性粒细胞增多和系统症状（drug reaction with eosinophilia and systemic symptoms，DRESS），又称药物超敏反应综合征（drug hypersensitivity syndrom，DIHS）是一种具有特异症候的重症药疹，致死率大约为10％。2006年2月15日，我科收治了1例DRESS综合征的患者，经过精心的治疗及护理，患者于住院13d后病情好转出院，现报道如下。展开更多
文摘Drug rash with eosinophilia and systemic symptoms (DRESS)-is characterized by fever, rash and internal organ involvement after exposure to certain drugs. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Cross-sensitivity between not only the aromatic anticonvulsants, but also the aromatic and non-aromatic anticonvulsants, is possible. We report here a case of a Korean woman who had previously tolerated valproate, but developed DRESS due to valproate after carbamazepine intake, which indicates cross-sensitivity. Her skin lesions displayed diffuse oedematous patches on the entire body associated with tense bullae on her arms and legs. Circulating auto-antibody to 190- kDa antigen was detected in the patient’ s serum by indirect immunofluorescence and immunoblotting, which might contribute to a pathogenic role in DRESS.
文摘重型药疹主要包括Stevens-Johnson综合征（重症型多形红斑．SJS）和中毒性表皮松解坏死症（TEN）、高敏综合征（Hypersensitivity Syndrome，HSS）又称伴嗜酸性粒细胞增多和系统症状的药物性发疹（Drug Rash with Eosinophilia and Systemic Symptoms，DRESS）。这些重型药疹的共同特点是发病急，多器官受累，治疗过程中易有反复，并发症多，死亡率高。
文摘药物疹伴嗜酸性粒细胞增多和系统症状（drug reaction with eosinophilia and systemic symptoms，DRESS），又称药物超敏反应综合征（drug hypersensitivity syndrom，DIHS）是一种具有特异症候的重症药疹，致死率大约为10％。2006年2月15日，我科收治了1例DRESS综合征的患者，经过精心的治疗及护理，患者于住院13d后病情好转出院，现报道如下。
