Drug rash with eosinophilia and systemic symptoms (DRESS)-is characterized by fever, rash and internal organ involvement after exposure to certain drugs. Most of the aromatic anticonvulsants, such as phenytoin, phenob...Drug rash with eosinophilia and systemic symptoms (DRESS)-is characterized by fever, rash and internal organ involvement after exposure to certain drugs. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Cross-sensitivity between not only the aromatic anticonvulsants, but also the aromatic and non-aromatic anticonvulsants, is possible. We report here a case of a Korean woman who had previously tolerated valproate, but developed DRESS due to valproate after carbamazepine intake, which indicates cross-sensitivity. Her skin lesions displayed diffuse oedematous patches on the entire body associated with tense bullae on her arms and legs. Circulating auto-antibody to 190- kDa antigen was detected in the patient’ s serum by indirect immunofluorescence and immunoblotting, which might contribute to a pathogenic role in DRESS.展开更多
药物疹伴嗜酸性粒细胞增多和系统症状（drug reaction with eosinophilia and systemic symptoms，DRESS），又称药物超敏反应综合征（drug hypersensitivity syndrom，DIHS）是一种具有特异症候的重症药疹，致死率大约为10％。2006年2...药物疹伴嗜酸性粒细胞增多和系统症状（drug reaction with eosinophilia and systemic symptoms，DRESS），又称药物超敏反应综合征（drug hypersensitivity syndrom，DIHS）是一种具有特异症候的重症药疹，致死率大约为10％。2006年2月15日，我科收治了1例DRESS综合征的患者，经过精心的治疗及护理，患者于住院13d后病情好转出院，现报道如下。展开更多
药物诱导的超敏反应综合征（drug induced hypersensitivitysyndrome,DIHS）又称伴嗜酸性粒细胞增多和系统症状的药物反应（Drug reaction with eosinophilia and systemic symptoms,DRESS）,是一种少见且可危及生命的药物不良反应,临...药物诱导的超敏反应综合征（drug induced hypersensitivitysyndrome,DIHS）又称伴嗜酸性粒细胞增多和系统症状的药物反应（Drug reaction with eosinophilia and systemic symptoms,DRESS）,是一种少见且可危及生命的药物不良反应,临床上具有药物过敏和病毒感染的复合特征,呈现多样化表现,容易误诊误治。2017年对本病临床研究主要体现在以下几个方面。展开更多
文摘Drug rash with eosinophilia and systemic symptoms (DRESS)-is characterized by fever, rash and internal organ involvement after exposure to certain drugs. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Cross-sensitivity between not only the aromatic anticonvulsants, but also the aromatic and non-aromatic anticonvulsants, is possible. We report here a case of a Korean woman who had previously tolerated valproate, but developed DRESS due to valproate after carbamazepine intake, which indicates cross-sensitivity. Her skin lesions displayed diffuse oedematous patches on the entire body associated with tense bullae on her arms and legs. Circulating auto-antibody to 190- kDa antigen was detected in the patient’ s serum by indirect immunofluorescence and immunoblotting, which might contribute to a pathogenic role in DRESS.
文摘药物疹伴嗜酸性粒细胞增多和系统症状（drug reaction with eosinophilia and systemic symptoms，DRESS），又称药物超敏反应综合征（drug hypersensitivity syndrom，DIHS）是一种具有特异症候的重症药疹，致死率大约为10％。2006年2月15日，我科收治了1例DRESS综合征的患者，经过精心的治疗及护理，患者于住院13d后病情好转出院，现报道如下。
文摘药物诱导的超敏反应综合征（drug induced hypersensitivitysyndrome,DIHS）又称伴嗜酸性粒细胞增多和系统症状的药物反应（Drug reaction with eosinophilia and systemic symptoms,DRESS）,是一种少见且可危及生命的药物不良反应,临床上具有药物过敏和病毒感染的复合特征,呈现多样化表现,容易误诊误治。2017年对本病临床研究主要体现在以下几个方面。
