By reviewing the current status and progress made by China and EU in ocean related fields in the changing world,this paper tries to identify the needs,characteristics and strategic importance of the China-EU Blue Part...By reviewing the current status and progress made by China and EU in ocean related fields in the changing world,this paper tries to identify the needs,characteristics and strategic importance of the China-EU Blue Partnership.The Blue Partnership proposed by the Chinese government is open and inclusive.It values mutual beneficial,and calls for broader cooperation.China-EU Blue Partnership is not only related to the development of both China and EU,but also will significantly contribute to the implementation of the UN 2030 Agenda for Sustainable Development.Some suggestions on the further development of the Partnership are proposed to facilitate the implementation.展开更多
One of the most distinctive features of China's recent foreign policy strategy is partnership diplomacy. It represents China's new approach to gaining influence over the global landscape. It is aimed at avoidi...One of the most distinctive features of China's recent foreign policy strategy is partnership diplomacy. It represents China's new approach to gaining influence over the global landscape. It is aimed at avoiding rivalry and conflict and reforming international relations to a more stable and friendly state. It also indicates China's intention to adopt a much more flexible and practical foreign policy. China will build a network of partnerships across the globe, forging a new kind of diplomacy with Chinese characteristics.展开更多
Chromatin structure is important for controlling gene expression, but mechanisms underlying chromatin remodel- ing are not fully understood. Here we report that an FKBP （FK506 binding protein） type immunophilin, AtF...Chromatin structure is important for controlling gene expression, but mechanisms underlying chromatin remodel- ing are not fully understood. Here we report that an FKBP （FK506 binding protein） type immunophilin, AtFKBP53, possesses histone chaperone activity and is required for repressing ribosomal gene expression in Arabidopsis. The At- FKBP53 protein is a multidomain FKBP with a typical peptidylprolyl isomerase （PPIase） domain and several highly charged domains. Using nucleosome assembly assays, we showed that AtFKBP53 has histone chaperone activity and the charged acidic domains are sufficient for the activity. We show that AtFKBP53 interacts with histone H3 through the acidic domains, whereas the PPIase domain is dispensable for histone chaperone activity or histone binding. Ri- bosomal RNA gene （18S rDNA） is overexpressed when AtFKBP53 activity is reduced or eliminated in Arabidopsis plants. Chromatin immunoprecipitation assay showed that AtFKBP53 is associated with the 18S rDNA gene chro- matin, implicating that AtFKBP53 represses rRNA genes at the chromatin level. This study identifies a new histone chaperone in plants that functions in chromatin remodeling and regulation of transcription.展开更多
基金supported by Project of study of the blue economic passage under the framework of global ocean governance(2019)at National Marine Data and Information ServiceSocial Science Foundation Project(18JZD059)supported by the Ministry of Education,China.
文摘By reviewing the current status and progress made by China and EU in ocean related fields in the changing world,this paper tries to identify the needs,characteristics and strategic importance of the China-EU Blue Partnership.The Blue Partnership proposed by the Chinese government is open and inclusive.It values mutual beneficial,and calls for broader cooperation.China-EU Blue Partnership is not only related to the development of both China and EU,but also will significantly contribute to the implementation of the UN 2030 Agenda for Sustainable Development.Some suggestions on the further development of the Partnership are proposed to facilitate the implementation.
文摘One of the most distinctive features of China's recent foreign policy strategy is partnership diplomacy. It represents China's new approach to gaining influence over the global landscape. It is aimed at avoiding rivalry and conflict and reforming international relations to a more stable and friendly state. It also indicates China's intention to adopt a much more flexible and practical foreign policy. China will build a network of partnerships across the globe, forging a new kind of diplomacy with Chinese characteristics.
基金We thank Veder Garcia （University of California, Berkeley, USA） for critically reading the paper, Zengyong He for providing the AtFKBP53：：GUS transgenic line and Masami Horikoshi （The University of Tokyo, Japan） for the pET-6His-SpFkbp39P plasmid. This work was supported by grants from the National Science Foundation and US Department of Energy （toSL）.
文摘Chromatin structure is important for controlling gene expression, but mechanisms underlying chromatin remodel- ing are not fully understood. Here we report that an FKBP （FK506 binding protein） type immunophilin, AtFKBP53, possesses histone chaperone activity and is required for repressing ribosomal gene expression in Arabidopsis. The At- FKBP53 protein is a multidomain FKBP with a typical peptidylprolyl isomerase （PPIase） domain and several highly charged domains. Using nucleosome assembly assays, we showed that AtFKBP53 has histone chaperone activity and the charged acidic domains are sufficient for the activity. We show that AtFKBP53 interacts with histone H3 through the acidic domains, whereas the PPIase domain is dispensable for histone chaperone activity or histone binding. Ri- bosomal RNA gene （18S rDNA） is overexpressed when AtFKBP53 activity is reduced or eliminated in Arabidopsis plants. Chromatin immunoprecipitation assay showed that AtFKBP53 is associated with the 18S rDNA gene chro- matin, implicating that AtFKBP53 represses rRNA genes at the chromatin level. This study identifies a new histone chaperone in plants that functions in chromatin remodeling and regulation of transcription.
