AIM: To study the effect of combined omeprazole(Ome) and domperidone(Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with ...AIM: To study the effect of combined omeprazole(Ome) and domperidone(Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastro- esophageal reflux diagnosed by 24-h esophageal pH moni- toring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symptom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbronchodilator forced expiratory volume in 1 second (FEVl) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9 %), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antireflux therapy compared to mean change in placebo group (P 〈 0.001). There was significant improvement in morning PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEW (11.1% vs 3.78%) and FVC (9.3%vs 1.52%) in the antireflux therapy group compared to placebo on comparng the mean change from baseline after 16 wk (P 〈 0.01) CONCLUSION: Combined therapy with Ome and Dom in adult asthmatics with gastroesophageal reflux may be beneficial by reducing asthma symptoms, rescuing medi- cation use, and improving pulmonary function.展开更多
The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contrac...The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contracts between players of different levels of the industry. Therefore, the aim of this work is the search for mechanisms that can provide value to the production phase to better increase competitiveness of the sector. For the first time, in fact, discussion about food chains have as reference a recognized legal entity, which is the integrated projects of food chain as a result of actions of agricultural policy at community, national and regional levels. The methodology is related to two steps: the administration of questionnaires to the three companies participating in food chain partnerships that have proposed a draft of integrated design of food chain in response to the notice of the Apulia region for the submission of the integrated projects of the food chain; and a cluster analysis in the wine sector of the Italian regions. The results showed, thanks to Network Analysis, the importance for the chain development of relationships formed by market relations and cooperation relations (formal and informal) and the need for more actions for the enhancement of products by research and development activities.展开更多
Introduction Neuroendocrine tumor covers a wide range of neoplasms that originate in the neuroendocrine cells which spread throughout the body. Carcinoid tumor,
基金a research grant from the University of Delhi, No. 52301/01Glaxo Smithkline Pharmaceuticals Limited and Dr. Reddy's Laboratories Ltd, No. 9834512
文摘AIM: To study the effect of combined omeprazole(Ome) and domperidone(Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastro- esophageal reflux diagnosed by 24-h esophageal pH moni- toring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symptom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbronchodilator forced expiratory volume in 1 second (FEVl) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9 %), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antireflux therapy compared to mean change in placebo group (P 〈 0.001). There was significant improvement in morning PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEW (11.1% vs 3.78%) and FVC (9.3%vs 1.52%) in the antireflux therapy group compared to placebo on comparng the mean change from baseline after 16 wk (P 〈 0.01) CONCLUSION: Combined therapy with Ome and Dom in adult asthmatics with gastroesophageal reflux may be beneficial by reducing asthma symptoms, rescuing medi- cation use, and improving pulmonary function.
文摘The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contracts between players of different levels of the industry. Therefore, the aim of this work is the search for mechanisms that can provide value to the production phase to better increase competitiveness of the sector. For the first time, in fact, discussion about food chains have as reference a recognized legal entity, which is the integrated projects of food chain as a result of actions of agricultural policy at community, national and regional levels. The methodology is related to two steps: the administration of questionnaires to the three companies participating in food chain partnerships that have proposed a draft of integrated design of food chain in response to the notice of the Apulia region for the submission of the integrated projects of the food chain; and a cluster analysis in the wine sector of the Italian regions. The results showed, thanks to Network Analysis, the importance for the chain development of relationships formed by market relations and cooperation relations (formal and informal) and the need for more actions for the enhancement of products by research and development activities.
文摘Introduction Neuroendocrine tumor covers a wide range of neoplasms that originate in the neuroendocrine cells which spread throughout the body. Carcinoid tumor,