The NI （non-inferiority） trial design based on the likelihood ratio test eliminates the dependency on the conventional NI margin, and it explicitly uses the MCID （minimum clinical important difference） that links ...The NI （non-inferiority） trial design based on the likelihood ratio test eliminates the dependency on the conventional NI margin, and it explicitly uses the MCID （minimum clinical important difference） that links the statistical analysis to the clinical sense. Different from the conventional trial design, the new methodology is self-adaptive to the change in the sample size and overall cure rate, and it has an asymptotic property. It is shown that MCID is de-composite into constant MCID and statistical MCID. Along with this concept, the concept of the allowed inferiority does not exist, the interpretation of the trial result is more accurate and consistent to the statistical theory as well as the clinical interpretations.展开更多
The denominations of origin being perceived by the consumers in terms of both intrinsic qualities and of extrinsic qualities, have contributed in no uncertain manner to the increase of the typical products in question...The denominations of origin being perceived by the consumers in terms of both intrinsic qualities and of extrinsic qualities, have contributed in no uncertain manner to the increase of the typical products in question, positively influenced also by the noted emergencies coming from verified alimentary alarms during the beginning of the XXI century. The objective of this paper, is to determine the habits of purchase of typical and traditional products of the people of Messina （Sicily, Italy）. To do this a ＂motivational＂ survey was carried out by traditional methodology of descriptive researches. The adopted methodology of research was quantitative and random. The random research strives to identify the factors that depend on the behaviour of purchase and the appraisal of the existing relationships of cause-effect in a determined population. The interviewed were given a questionnaire composed of 17 questions on their knowledge of the typical products characteristics, the frequency of consumption, the monthly amounts destined to the purchase, the motivations that push them to the purchase of typical products rather than pre-packed. Methodologically, our statistical analysis has been performed using the log-likelihood ratio test in order to investigate the existence of association between the joint distributions of qualitative measured variables.展开更多
基金Supported by the National Natural Science Foundation in China(30671126)Natural Science Foundation in Shandong Universi-ty of Technology(4040306017)+1 种基金Startup Foundation for Ph.D in Shandong University of Technology(4041-4050174041-405016)
文摘The NI （non-inferiority） trial design based on the likelihood ratio test eliminates the dependency on the conventional NI margin, and it explicitly uses the MCID （minimum clinical important difference） that links the statistical analysis to the clinical sense. Different from the conventional trial design, the new methodology is self-adaptive to the change in the sample size and overall cure rate, and it has an asymptotic property. It is shown that MCID is de-composite into constant MCID and statistical MCID. Along with this concept, the concept of the allowed inferiority does not exist, the interpretation of the trial result is more accurate and consistent to the statistical theory as well as the clinical interpretations.
文摘The denominations of origin being perceived by the consumers in terms of both intrinsic qualities and of extrinsic qualities, have contributed in no uncertain manner to the increase of the typical products in question, positively influenced also by the noted emergencies coming from verified alimentary alarms during the beginning of the XXI century. The objective of this paper, is to determine the habits of purchase of typical and traditional products of the people of Messina （Sicily, Italy）. To do this a ＂motivational＂ survey was carried out by traditional methodology of descriptive researches. The adopted methodology of research was quantitative and random. The random research strives to identify the factors that depend on the behaviour of purchase and the appraisal of the existing relationships of cause-effect in a determined population. The interviewed were given a questionnaire composed of 17 questions on their knowledge of the typical products characteristics, the frequency of consumption, the monthly amounts destined to the purchase, the motivations that push them to the purchase of typical products rather than pre-packed. Methodologically, our statistical analysis has been performed using the log-likelihood ratio test in order to investigate the existence of association between the joint distributions of qualitative measured variables.
