Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods...Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods： 140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size, necrosis or cyst formation, radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated. Results： The efficiency rate was 84.3%. The salient efficiency rates were 54.3% for total and 30%, 36.4%, 50%, 68%, 69.2%, and 73.1% for segmenting, respectively. Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation. Radiation-induced oedema occurred for 32.7%. The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like. Conclusion： Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma. The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up. Radiobiological effect affect the efficacy evaluation. MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.展开更多
Objective:To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma. Methods:Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic bo...Objective:To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma. Methods:Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic body radiotherapy. Planning of treatment was made and the prescribed dose was adjusted depending on the site of the tumor,clinical target volume(GTV),Kanofsky Performance and aim of treatment.Planning target volume received 50%–80%of the prescribed dose for 3.2–4.2 Gy per-fraction.Treatment total dose was 32–42 Gy(median dose 40 Gy)in daily fractions of 3.2–4.2 Gy for five fractions one week.Results:All the patients completed the planned radiotherapy.The tumor response rate was CR 25.9%,PR 55.6%,NR 18.59%;the response rate(CR+PR)was 81.5%.Half-year local recurrence-free survival rate was 75%;1-year local recurrence-free survival rate was 22%.There were no serious complications during radiotherapy and follow- up.Pain relieve rate in liver region was 83.3%.Conclusion:Stereotactic body radiotherapy can improve the local control and quality of life on the treatment of primary hepatic neoplasm while not increasing the treatment complication.展开更多
基金Guangzhou Medical Science Project (No. 2006-YB-169)
文摘Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods： 140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size, necrosis or cyst formation, radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated. Results： The efficiency rate was 84.3%. The salient efficiency rates were 54.3% for total and 30%, 36.4%, 50%, 68%, 69.2%, and 73.1% for segmenting, respectively. Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation. Radiation-induced oedema occurred for 32.7%. The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like. Conclusion： Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma. The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up. Radiobiological effect affect the efficacy evaluation. MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.
文摘Objective:To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma. Methods:Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic body radiotherapy. Planning of treatment was made and the prescribed dose was adjusted depending on the site of the tumor,clinical target volume(GTV),Kanofsky Performance and aim of treatment.Planning target volume received 50%–80%of the prescribed dose for 3.2–4.2 Gy per-fraction.Treatment total dose was 32–42 Gy(median dose 40 Gy)in daily fractions of 3.2–4.2 Gy for five fractions one week.Results:All the patients completed the planned radiotherapy.The tumor response rate was CR 25.9%,PR 55.6%,NR 18.59%;the response rate(CR+PR)was 81.5%.Half-year local recurrence-free survival rate was 75%;1-year local recurrence-free survival rate was 22%.There were no serious complications during radiotherapy and follow- up.Pain relieve rate in liver region was 83.3%.Conclusion:Stereotactic body radiotherapy can improve the local control and quality of life on the treatment of primary hepatic neoplasm while not increasing the treatment complication.
