In order to investigate more realistic group scheduling problems with position-dependent effects,the model of general position-dependent group scheduling is proposed,where the actual group setup times and actual proce...In order to investigate more realistic group scheduling problems with position-dependent effects,the model of general position-dependent group scheduling is proposed,where the actual group setup times and actual processing times are described by general functions of the normal group setup time and position in the sequence.These general functions are not assumed to have specific function structures,and are not restricted to be monotone.By mathematical analysis and proof,each considered problem is decomposed into a group scheduling process and a job scheduling process,and each scheduling process is transferred into the classic assignment problem or the classic single-machine sequence problem,and then the computational complexity to solve the considered problem is analyzed.Analysis results show that,even with general position-dependent job processing times,both the single machine makespan minimization group scheduling problems and the parallel-machine total load minimization group scheduling problems remain polynomially solvable.展开更多
AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterd...AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.展开更多
The drum shearer and high pressure water jet combined cutting system is an effective technology to cut hard coal-rock, but one problem of the technology is the choice of pick and nozzle location parameters. In order t...The drum shearer and high pressure water jet combined cutting system is an effective technology to cut hard coal-rock, but one problem of the technology is the choice of pick and nozzle location parameters. In order to solve the problem, the process and mechanism of combined cutting arc studied and mining seepage catastrophe theory is used to construct the mathematic and physical model of combined cutting hard coal-rock. Based on the model and detailed analysis of combined cutting mechanism, the single pick and nozzle combined cutting test-bed is built to test the main pick and nozzle location parameters of drum shearer and water jet combined cutting system. Test results show that the best vertical distance between the pick-tip and nozzle center point is the sum of cutting thickness and proper target distance in the Y axial direction; the best horizontal distance is the length between pick-tip point and coal-rock surface bursting crack point in the X axial direction. The best incident angle of water jet should be the same as the bursting crack line's angle in theory, but considering other important factors comprehensively, it is more reasonable when the incident angle of water jet is 90°.展开更多
The goal of this research is to investigate the ideas that functioned in shaping thought of Radif in Iranian Dastgahi music. In this regard by preparing the reasons, we pay attention to the function of education in co...The goal of this research is to investigate the ideas that functioned in shaping thought of Radif in Iranian Dastgahi music. In this regard by preparing the reasons, we pay attention to the function of education in codification of Radif. Although Iranian traditional music has long history but its codification to seven Dastgah-s and five Avaz-es in the format of Radif is attributed to Qajar Dynasty in the 19th century. In this transformation, Mirza Abdollah, Tar-Player of the Nasser al-Din Shah Period, has played an important role in final codification of Radif. Due to the truth that the past masters scrimped in music education, and Mirza Abdollah had encountered with problems to learn music, hence he has mostly cared about music education in adulthood, and it is probable that one of the reasons in collecting Gusheh-s (approximately a small piece of the Iranian Dastgahi music) and organizing them into coherent sets was making simplicity for the students to learn. Furthermore, masters who seriously and continuously have taught after Mirza Abdollah, left a narration (version) of Radif. On the other hand, definite patterns in placement of Gusheh-s and phrases of the Radif have been organized in a manner that makes educational function for it.展开更多
Fifteen turmeric genotypes from the germplasm held at National Root Crops Research Institute Umudike, Nigeria, were evaluated during the season of 2012-2013 at four locations-Jos (8.3833°N, 7.1833°E, 1,200 ...Fifteen turmeric genotypes from the germplasm held at National Root Crops Research Institute Umudike, Nigeria, were evaluated during the season of 2012-2013 at four locations-Jos (8.3833°N, 7.1833°E, 1,200 m a.s.l.), Otobi (7.11667°N and 8.08333°E), Umudike (5.4758°N, 7.5489°E) and Igbariam (6.4°N and 6.93333°E)-in order to select high yielding and stable turmeric cultivars with good quality for release in Nigeria. At each location, the experiment was laid out in randomized complete block design (RCBD) in three replications. Plot size was 9 m2. Data were collected on sprout count, plant height, number of tillers, number of leaves, main pseudo stem girth, rhizome number and weight. Analysis of variance was carried out on the combined data using GenStat Discovery Edition software. Results based on the combined data from four locations indicate that turmeric genotypes did not vary in percentage emergence and number of leaves. However, they varied in height, main pseudo stem girth, tillering, number and yield of fresh rhizomes. The effect of location on all attributes was significant (P 〈 0.05) with Jos location giving consistently the least values for all attributes thus suggesting that this location may not be suitable for the commercial production of turmeric. Genotype by environment interaction for most attributes was not significant indicating that the genotypes responded the same way across the locations. Ten genotypes, viz., UT39, UT44, UT46, UT58, UT50, UTI4, UT41, UT6, UT38 and UT35, are identified as promising and require further evaluation as pre-condition for nomination for official release to farmers.展开更多
This paper presents Isotope, an efficient, locality aware, fault-tolerant, and decentralized scheme for data location in distributed networks. This scheme is designed based on the mathematical model of decentralized l...This paper presents Isotope, an efficient, locality aware, fault-tolerant, and decentralized scheme for data location in distributed networks. This scheme is designed based on the mathematical model of decentralized location services and thus has provable correctness and performance. In Isotope, each node needs to only maintain linkage information with about O(log n) other nodes and any node can be reached within O(log n) routing hops. Compared with other related schemes, Isotope’s average locating path length is only half that of Chord, and its locating performance and locality-awareness are similar to that of Pastry and Tapestry. In addition, Isotope is more suitable for constantly changing networks because it needs to exchange only O(log n) O(log n) messages to update the routing information for nodes arrival, departure and failure.展开更多
In the period 2003-2011, lightning over-voltages accounted for about 47% of the total number of distribution transformer failures observed in the service area ofAES Sul, a power company that operates in the state of R...In the period 2003-2011, lightning over-voltages accounted for about 47% of the total number of distribution transformer failures observed in the service area ofAES Sul, a power company that operates in the state of Rio Grande doSul, in South Brazil. This paper presents the results of an investigation on the influence of the distance between transformer and MV arresters on the surges at the transformer windings caused by direct strikes to the MV network. The analysis, performed through simulations using the Alternative Transients Program, shows that in general higher voltages are produced by subsequent strokes. Although in relation to the primary side the surges transferred to the secondary are much less affected by the distance between transformers and primary arresters, such distance should always be kept as short as possible in order to reduce the probability of occurrence of transformer failures due to over-voltages at the MV bushings.展开更多
Spatial transcriptomics is an organizational study done on tissue sections that preserves the spatial information of the sample.Spatial transcriptomics aims to combine spatial information with gene expression data to ...Spatial transcriptomics is an organizational study done on tissue sections that preserves the spatial information of the sample.Spatial transcriptomics aims to combine spatial information with gene expression data to quantify the mRNA expression of a large number of genes in the spatial context of tissues and cells.As a paradigm shift in biological research,spatial transcriptomics can provide both spatial location information and transcriptome-level cellular gene expression data,elucidating the interactions between cells and the microenvironment.From the understanding of the entire functional life cycle of RNA to the characterization of molecular mechanisms to the mapping of gene expression in various tissue regions,by choosing the appropriate spatial transcriptome technology,researchers can achieve a deeper exploration of biological developmental processes,disease pathogenesis,etc.In recent years,the field of spatial transcriptomics has ushered in several challenges along with its rapid development,such as the dependence on sample types,the resolution of visualized genes,the difficulty of commercialization,and the ability to obtain detailed single-cell information.In this paper,we summarize and review the four major categories of spatial transcriptome technologies and compare and analyze the technical advantages and major challenges of multiple research strategies to assist current experimental design and research analysis.Finally,the importance of spatial transcriptomics in the integration of multi-omics analysis and disease modeling as well as the future development prospects are summarized and outlined.展开更多
The West Pingdingshan Section in Chaohu, Anhui Province, has been extensively studied in recent years and become one of the classic Lower Triassic sequences well-clarified in multiple stratigraphies. Also it is an imp...The West Pingdingshan Section in Chaohu, Anhui Province, has been extensively studied in recent years and become one of the classic Lower Triassic sequences well-clarified in multiple stratigraphies. Also it is an important section that defines the Smithian-Spathian (S-S) boundary within the Olenekian Stage. The S-S boundary strata at the section are restudied in high-resolution conodont biostratigraphy and carbon isotopes. The refined S-S boundary defined by the FAD of conodont Neospathodus pingdingshanensis is at 30 cm above the base of Bed 52, corresponding to a rapid diversification of conodonts. A sharp positive shift of δ13Ccarb curve co-occurs at the S-S boundary and it can be used as a key reference to define the boundary. The defined S-S boundary position and carbon isotopes curve can be well correlated globally.展开更多
Extensibility and attainability of topology optimization are discussed by investigating a variety of simultaneous topology opti-mization methods extended from the standard formulation.First,the state of the art is hig...Extensibility and attainability of topology optimization are discussed by investigating a variety of simultaneous topology opti-mization methods extended from the standard formulation.First,the state of the art is highlighted through systematic classification of developed methods,such as simultaneous topology optimizations of microstructure and macrostructure,structure and supports,structure and design-dependent loads,structure and locations of involved components.Second,some recent results about simultaneous topology optimization of structure and applied loads are presented.It is shown that the simultaneous topology optimization is an integrated methodology that extends the concept of standard topology optimization in the sense of systematic design.The presence of more than one kind of design variable of different nature makes the optimization problem complex but enlarges the design space to attain the optimization.展开更多
Chloroplasts are organelles found in plant cells that conduct photosynthesis. The subchloroplast locations of proteins are correlated with their functions. With the availability of a great number of protein data, it i...Chloroplasts are organelles found in plant cells that conduct photosynthesis. The subchloroplast locations of proteins are correlated with their functions. With the availability of a great number of protein data, it is highly desired to develop a com- putational method to predict the subchloroplast locations of chloroplast proteins. In this study, we proposed a novel method to predict subchloroplast locations of proteins using tripeptide compositions. It first used the binomial distribution to optimize the feature sets. Then the support vector machine was selected to perform the prediction of subchloroplast locations of proteins. The proposed method was tested on a reliable and rigorous dataset including 259 chloroplast proteins with sequence identity ≤ 25%. In the jack-knife cross-validation, 92.21% envelope proteins, 93.20% thylakoid mem- brane, 52.63% thylakoid lumen and 85.00% stroma can be correctly identified. The overall accuracy achieves 88.03% which is higher than that of other models. Based on this method, a predictor called ChloPred has been built and can be freely available from http://cobi.uestc.edu.cn/people/hlin/tools/ChloPred/. The predictor will provide important information for theoretical and experimental research of chloroplast proteins.展开更多
基金The National Natural Science Foundation of China (No.71171046)the Scientific Research Innovation Project for College Graduates in Jiangsu Province(No.CXLX_0162)
文摘In order to investigate more realistic group scheduling problems with position-dependent effects,the model of general position-dependent group scheduling is proposed,where the actual group setup times and actual processing times are described by general functions of the normal group setup time and position in the sequence.These general functions are not assumed to have specific function structures,and are not restricted to be monotone.By mathematical analysis and proof,each considered problem is decomposed into a group scheduling process and a job scheduling process,and each scheduling process is transferred into the classic assignment problem or the classic single-machine sequence problem,and then the computational complexity to solve the considered problem is analyzed.Analysis results show that,even with general position-dependent job processing times,both the single machine makespan minimization group scheduling problems and the parallel-machine total load minimization group scheduling problems remain polynomially solvable.
文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.
基金Project(2012AA062104) supported by the National High Technology Research and Development Program of ChinaProject(201104583) supported by the Postdoctoral Special Funded Projects,China
文摘The drum shearer and high pressure water jet combined cutting system is an effective technology to cut hard coal-rock, but one problem of the technology is the choice of pick and nozzle location parameters. In order to solve the problem, the process and mechanism of combined cutting arc studied and mining seepage catastrophe theory is used to construct the mathematic and physical model of combined cutting hard coal-rock. Based on the model and detailed analysis of combined cutting mechanism, the single pick and nozzle combined cutting test-bed is built to test the main pick and nozzle location parameters of drum shearer and water jet combined cutting system. Test results show that the best vertical distance between the pick-tip and nozzle center point is the sum of cutting thickness and proper target distance in the Y axial direction; the best horizontal distance is the length between pick-tip point and coal-rock surface bursting crack point in the X axial direction. The best incident angle of water jet should be the same as the bursting crack line's angle in theory, but considering other important factors comprehensively, it is more reasonable when the incident angle of water jet is 90°.
文摘The goal of this research is to investigate the ideas that functioned in shaping thought of Radif in Iranian Dastgahi music. In this regard by preparing the reasons, we pay attention to the function of education in codification of Radif. Although Iranian traditional music has long history but its codification to seven Dastgah-s and five Avaz-es in the format of Radif is attributed to Qajar Dynasty in the 19th century. In this transformation, Mirza Abdollah, Tar-Player of the Nasser al-Din Shah Period, has played an important role in final codification of Radif. Due to the truth that the past masters scrimped in music education, and Mirza Abdollah had encountered with problems to learn music, hence he has mostly cared about music education in adulthood, and it is probable that one of the reasons in collecting Gusheh-s (approximately a small piece of the Iranian Dastgahi music) and organizing them into coherent sets was making simplicity for the students to learn. Furthermore, masters who seriously and continuously have taught after Mirza Abdollah, left a narration (version) of Radif. On the other hand, definite patterns in placement of Gusheh-s and phrases of the Radif have been organized in a manner that makes educational function for it.
文摘Fifteen turmeric genotypes from the germplasm held at National Root Crops Research Institute Umudike, Nigeria, were evaluated during the season of 2012-2013 at four locations-Jos (8.3833°N, 7.1833°E, 1,200 m a.s.l.), Otobi (7.11667°N and 8.08333°E), Umudike (5.4758°N, 7.5489°E) and Igbariam (6.4°N and 6.93333°E)-in order to select high yielding and stable turmeric cultivars with good quality for release in Nigeria. At each location, the experiment was laid out in randomized complete block design (RCBD) in three replications. Plot size was 9 m2. Data were collected on sprout count, plant height, number of tillers, number of leaves, main pseudo stem girth, rhizome number and weight. Analysis of variance was carried out on the combined data using GenStat Discovery Edition software. Results based on the combined data from four locations indicate that turmeric genotypes did not vary in percentage emergence and number of leaves. However, they varied in height, main pseudo stem girth, tillering, number and yield of fresh rhizomes. The effect of location on all attributes was significant (P 〈 0.05) with Jos location giving consistently the least values for all attributes thus suggesting that this location may not be suitable for the commercial production of turmeric. Genotype by environment interaction for most attributes was not significant indicating that the genotypes responded the same way across the locations. Ten genotypes, viz., UT39, UT44, UT46, UT58, UT50, UTI4, UT41, UT6, UT38 and UT35, are identified as promising and require further evaluation as pre-condition for nomination for official release to farmers.
基金Sponsored by the National Natural Science Foundation of China(Grant No.60073074).
文摘This paper presents Isotope, an efficient, locality aware, fault-tolerant, and decentralized scheme for data location in distributed networks. This scheme is designed based on the mathematical model of decentralized location services and thus has provable correctness and performance. In Isotope, each node needs to only maintain linkage information with about O(log n) other nodes and any node can be reached within O(log n) routing hops. Compared with other related schemes, Isotope’s average locating path length is only half that of Chord, and its locating performance and locality-awareness are similar to that of Pastry and Tapestry. In addition, Isotope is more suitable for constantly changing networks because it needs to exchange only O(log n) O(log n) messages to update the routing information for nodes arrival, departure and failure.
文摘In the period 2003-2011, lightning over-voltages accounted for about 47% of the total number of distribution transformer failures observed in the service area ofAES Sul, a power company that operates in the state of Rio Grande doSul, in South Brazil. This paper presents the results of an investigation on the influence of the distance between transformer and MV arresters on the surges at the transformer windings caused by direct strikes to the MV network. The analysis, performed through simulations using the Alternative Transients Program, shows that in general higher voltages are produced by subsequent strokes. Although in relation to the primary side the surges transferred to the secondary are much less affected by the distance between transformers and primary arresters, such distance should always be kept as short as possible in order to reduce the probability of occurrence of transformer failures due to over-voltages at the MV bushings.
基金supported by the National Natural Science Foundation of China(Grant No.22275071)
文摘Spatial transcriptomics is an organizational study done on tissue sections that preserves the spatial information of the sample.Spatial transcriptomics aims to combine spatial information with gene expression data to quantify the mRNA expression of a large number of genes in the spatial context of tissues and cells.As a paradigm shift in biological research,spatial transcriptomics can provide both spatial location information and transcriptome-level cellular gene expression data,elucidating the interactions between cells and the microenvironment.From the understanding of the entire functional life cycle of RNA to the characterization of molecular mechanisms to the mapping of gene expression in various tissue regions,by choosing the appropriate spatial transcriptome technology,researchers can achieve a deeper exploration of biological developmental processes,disease pathogenesis,etc.In recent years,the field of spatial transcriptomics has ushered in several challenges along with its rapid development,such as the dependence on sample types,the resolution of visualized genes,the difficulty of commercialization,and the ability to obtain detailed single-cell information.In this paper,we summarize and review the four major categories of spatial transcriptome technologies and compare and analyze the technical advantages and major challenges of multiple research strategies to assist current experimental design and research analysis.Finally,the importance of spatial transcriptomics in the integration of multi-omics analysis and disease modeling as well as the future development prospects are summarized and outlined.
基金supported by Ministry of Science and Technology (Grant No. 2006FY120300-11)National Natural Science Foundation of China (Grant Nos. 40830212, 40921062, 40972003)
文摘The West Pingdingshan Section in Chaohu, Anhui Province, has been extensively studied in recent years and become one of the classic Lower Triassic sequences well-clarified in multiple stratigraphies. Also it is an important section that defines the Smithian-Spathian (S-S) boundary within the Olenekian Stage. The S-S boundary strata at the section are restudied in high-resolution conodont biostratigraphy and carbon isotopes. The refined S-S boundary defined by the FAD of conodont Neospathodus pingdingshanensis is at 30 cm above the base of Bed 52, corresponding to a rapid diversification of conodonts. A sharp positive shift of δ13Ccarb curve co-occurs at the S-S boundary and it can be used as a key reference to define the boundary. The defined S-S boundary position and carbon isotopes curve can be well correlated globally.
基金supported by the National Natural Science Foundation of China(Grant Nos.51275424,51221001)the National Basic Research Program of China("973"Project)(Grant No.2011CB610304)+1 种基金the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20126102130003)the NWPU Foundation for Fundamental Research(Grant No.NPU-FFR-201001)
文摘Extensibility and attainability of topology optimization are discussed by investigating a variety of simultaneous topology opti-mization methods extended from the standard formulation.First,the state of the art is highlighted through systematic classification of developed methods,such as simultaneous topology optimizations of microstructure and macrostructure,structure and supports,structure and design-dependent loads,structure and locations of involved components.Second,some recent results about simultaneous topology optimization of structure and applied loads are presented.It is shown that the simultaneous topology optimization is an integrated methodology that extends the concept of standard topology optimization in the sense of systematic design.The presence of more than one kind of design variable of different nature makes the optimization problem complex but enlarges the design space to attain the optimization.
文摘Chloroplasts are organelles found in plant cells that conduct photosynthesis. The subchloroplast locations of proteins are correlated with their functions. With the availability of a great number of protein data, it is highly desired to develop a com- putational method to predict the subchloroplast locations of chloroplast proteins. In this study, we proposed a novel method to predict subchloroplast locations of proteins using tripeptide compositions. It first used the binomial distribution to optimize the feature sets. Then the support vector machine was selected to perform the prediction of subchloroplast locations of proteins. The proposed method was tested on a reliable and rigorous dataset including 259 chloroplast proteins with sequence identity ≤ 25%. In the jack-knife cross-validation, 92.21% envelope proteins, 93.20% thylakoid mem- brane, 52.63% thylakoid lumen and 85.00% stroma can be correctly identified. The overall accuracy achieves 88.03% which is higher than that of other models. Based on this method, a predictor called ChloPred has been built and can be freely available from http://cobi.uestc.edu.cn/people/hlin/tools/ChloPred/. The predictor will provide important information for theoretical and experimental research of chloroplast proteins.