The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns. Because of the peculiar arrangement and configurati...The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns. Because of the peculiar arrangement and configuration of epidermal rete ridges in the glabrous skin, the traditional histological picture does not provide an exact correlation with ELM features. In particular, the fibrillar pattern lacks a histopathological correlate. To clarify the microscopic features of the fibrillar pattern, we used transverse histological sectioning to study an acquired compound melanocytic naevus of the sole, characterized by a mixedparallel-furrow/fibrillar pattern on ELM. Low-magnificati-on images of transverse sections allowed us to highlight the typical anatomical arrangement of the volar skin clearly, while high-magnification images demonstrated that the fibrillar pattern corresponded to parallel striae of intensely pigmented corneocytes arranged obliquely to the cutaneous surface.展开更多
前列腺癌在全球范围内日益增长的发病率严重威胁着老年男性的健康[1]。Gleason评分系统是由Gleason[2]在1966年手绘制出来的前列腺癌组织的生长特征的体系。多年来,国际泌尿病理协会(International society of urological pathology,IS...前列腺癌在全球范围内日益增长的发病率严重威胁着老年男性的健康[1]。Gleason评分系统是由Gleason[2]在1966年手绘制出来的前列腺癌组织的生长特征的体系。多年来,国际泌尿病理协会(International society of urological pathology,ISUP)对该评分体系进行不断地修改和完善,使得Gleason评分变成目前临床上评价前列腺癌生物学特性、分化程度、疗效等方面不可或缺的指标之一[3]。Gleason评分是基于在低倍镜下前列腺癌腺体结构及浸润程度进,其联合评分包括前列腺癌的主要成分和次要成分,评分越高,肿瘤分化程度越低,预后越差。前列腺癌死亡率较高[4]。展开更多
文摘The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns. Because of the peculiar arrangement and configuration of epidermal rete ridges in the glabrous skin, the traditional histological picture does not provide an exact correlation with ELM features. In particular, the fibrillar pattern lacks a histopathological correlate. To clarify the microscopic features of the fibrillar pattern, we used transverse histological sectioning to study an acquired compound melanocytic naevus of the sole, characterized by a mixedparallel-furrow/fibrillar pattern on ELM. Low-magnificati-on images of transverse sections allowed us to highlight the typical anatomical arrangement of the volar skin clearly, while high-magnification images demonstrated that the fibrillar pattern corresponded to parallel striae of intensely pigmented corneocytes arranged obliquely to the cutaneous surface.
文摘前列腺癌在全球范围内日益增长的发病率严重威胁着老年男性的健康[1]。Gleason评分系统是由Gleason[2]在1966年手绘制出来的前列腺癌组织的生长特征的体系。多年来,国际泌尿病理协会(International society of urological pathology,ISUP)对该评分体系进行不断地修改和完善,使得Gleason评分变成目前临床上评价前列腺癌生物学特性、分化程度、疗效等方面不可或缺的指标之一[3]。Gleason评分是基于在低倍镜下前列腺癌腺体结构及浸润程度进,其联合评分包括前列腺癌的主要成分和次要成分,评分越高,肿瘤分化程度越低,预后越差。前列腺癌死亡率较高[4]。
