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地西他滨与环孢素治疗低危性骨髓增生异常综合征对照观察 被引量:1
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作者 王慧睿 《临床心身疾病杂志》 CAS 2017年第3期132-133,共2页
目的 比较地西他滨与环孢素治疗低危性骨髓增生异常综合征的临床疗效及安全性. 方法 将31例低危性骨髓增生异常综合征患者按治疗方案分为地西他滨组14例,环孢素组17例,前者给予低剂量地西他滨治疗,后者给予环孢素治疗,随访1 a.观察比较... 目的 比较地西他滨与环孢素治疗低危性骨髓增生异常综合征的临床疗效及安全性. 方法 将31例低危性骨髓增生异常综合征患者按治疗方案分为地西他滨组14例,环孢素组17例,前者给予低剂量地西他滨治疗,后者给予环孢素治疗,随访1 a.观察比较两组患者临床总有效率、不良反应发生率及随访1 a生存率.结果 地西他滨组总有效率为35.7%,环孢素组为64.7%,两组比较差异无统计学意义(P〉0.05).地西他滨组不良反应表现为骨髓抑制(5例)、肺部感染(5例)、腹腔感染(3例),环孢素组表现为肺部感染(1例).地西他滨组随访1 a生存率为78.6%,环孢素组为100%,地西他滨组显著低于环孢素组(P〈0.05).结论 地西他滨治疗低危性骨髓增生异常综合征疗效与环孢素无明显差异,但更易引起骨髓抑制等不良反应,患者耐受性较差、1 a内生存率较低. 展开更多
关键词 骨髓增生异常综合征 低危性 地西他滨 环孢素 临床疗效
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经食道心脏超声和经胸壁心脏超声在心源性栓塞性脑梗死诊断价值 被引量:7
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作者 王华 褚雯 +2 位作者 段智慧 张守彦 李天天 《现代医用影像学》 2019年第2期347-349,共3页
目的:观察心源性栓塞性脑梗死应用经食道心脏超声、经胸壁心脏超声的诊断价值。方法:临床资料采集我院2017年7月-2018年7月神经科诊治的108例CES患者,按不同诊断方法分2组,每组54例,对照组行经胸壁心脏超声检查,观察组行经食道心脏超声... 目的:观察心源性栓塞性脑梗死应用经食道心脏超声、经胸壁心脏超声的诊断价值。方法:临床资料采集我院2017年7月-2018年7月神经科诊治的108例CES患者,按不同诊断方法分2组,每组54例,对照组行经胸壁心脏超声检查,观察组行经食道心脏超声检查,比较两组CES检查率。结果:经心脏超声检查,观察组检出房间隔缺损6例(11.11%)、主动脉斑块1例(1.85%)、房间隔瘤4例(7.41%)、卵圆孔未闭2例(3.70%)、左方自发声学显影1例(1.85)、二尖瓣脱垂1例(1.85%)、二尖瓣增厚2例(3.70%),CES总计17例;对照组检出主动脉斑块1例(1.85%)、二尖瓣脱垂1例(1.85%)、二尖瓣增厚2例(3.70%),CES总计4例;观察组的CES检出率31.48%相比对照组7.41%明显较高,比较差异显著具统计意义(P<0.05)。结论:经食道心脏超声诊断心源性栓塞性脑梗死的效果更为显著,检出率更高。 展开更多
关键词 心源性栓塞性脑梗死 心脏超声 经食道检查 经胸壁检查 危性 低危性
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Study of Space Reactors for Exploration Missions
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作者 Elisa Cloquet Jean-Marc Ruault +5 位作者 Frederic Masson Jean-Pierre Roux Nicolas Paris Brice Cazale Laurent Manifacier Christine Poinot-Salanon 《Journal of Energy and Power Engineering》 2014年第8期1393-1408,共16页
Nuclear propulsion has been studied for many decades. The power density of nuclear fission is much higher than chemical process, and for missions to outer solar system requiring several hundred of kilowatts, or for fl... Nuclear propulsion has been studied for many decades. The power density of nuclear fission is much higher than chemical process, and for missions to outer solar system requiring several hundred of kilowatts, or for flexible manned missions to Mars requiring several megawatts, nuclear electric propulsion might be the only option offering a reasonable mass in low earth orbit. Despite the existence of low power experiences--SNAP10 in the 60's or Buk/Topaz in the 60-80's--no high power reactor has been developed: investment cost, long term timeframe, high technological challenges and radioactive hazards are the main challenges we must overtake. However, it seems reasonable to look at the technical challenges that have to be overcome for a next generation of nuclear electric systems for space exploration. This paper will present some recent studies going on in France, on space reactors for exploration. Three classes of power have been considered: 10 kWe, 100 kWe, and several megawatts. Available data from previous studies and developments performed in Russia, USA, and Europe have been collected and gave us a large overview of potential technical solutions. This was the starting point of a trade-off analysis aiming at the selection of the best options, with regards to the technological readiness level in France and Europe. The resulting preliminary designs will be presented and critical technologies needing maturation activities will be highlighted. 展开更多
关键词 Spatial nuclear reactor nuclear energy nuclear propulsion
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