目的:探究非同型血输注在急救低血容性休克患者中的临床疗效及安全性,以期为提高急救低血容性休克患者的抢救成功率提供参考借鉴。方法:选取2017年9~2020年9月收治的因低血容性休克而需紧急输血的52例患者作为研究对象,遵循随机抽样原...目的:探究非同型血输注在急救低血容性休克患者中的临床疗效及安全性,以期为提高急救低血容性休克患者的抢救成功率提供参考借鉴。方法:选取2017年9~2020年9月收治的因低血容性休克而需紧急输血的52例患者作为研究对象,遵循随机抽样原则将患者分为对照组26例以及治疗组26例。其中,对照组患者遵循急诊输血流程输注与患者血型相合,配血相容的血液,治疗组患者紧急进行O型血输注抢救。通过比较两组患者抢救成功率、等候时间以及输血前后总胆红素(TBIL)、间接胆红素(IBIL)和血浆游离血红蛋白(FHb)等指标的差异。结果:对照组患者抢救成功率为50.0%(13/26),治疗组患者的抢救成功率为84.6%(22/26),两组间的差异具有统计学意义(P<0.05)。此外,治疗组患者的等候时间显著低于对照组(17.2±3.2 min VS.48.7±9.0 min,P<0.05)。在输血前后,治疗组与对照组患者TBIL、IBIL以及FHb等指标差异无统计学意义(P>0.05)。结论:非同型血输注能有效提高低血容性休克患者的抢救成功率,缩短患者等候时间,并具有与同型血输注类似的疗效,具有较大的临床应用价值。展开更多
Objective： To investigate the effects of two fluid resuscitations on the bacterial translocation and the inflammatory factors of small intestine in rats with hemorrhagic shock. Methods： Fifty SD healthy male rats we...Objective： To investigate the effects of two fluid resuscitations on the bacterial translocation and the inflammatory factors of small intestine in rats with hemorrhagic shock. Methods： Fifty SD healthy male rats were randomly divided into 5 groups （ n = 10 per group） ： Group A （ Sham group）, Group B （ Ringer＇ s solution for 1 h ）, Group C （Ringer＇ s solution for 24 h ）, Group D （ hydroxyethyl starch for 1 h ） and Group E （（ hydroxyethyl starch for 24 h）. A model of rats with hemorrhagic shock was established. The bacterial translocation in liver, content of tumor necrosis factor-α （TNF-α） and changes of myeloperoxidase enzyme （MPO） activities in small intestine were pathologically investigated after these two fluid resuscitations, respectively. Results ： The bacterial translocation and the expression of TNF-α in the small intestine were detected at 1 h and 24 h after fluid resuscitation. There were significant increase in the number of translocated bacteria, TNF-α and MPO activities in Group C compared with Group B, significant decrease in Group E compared with Group D and in Group B compared with Group D. The number of translocated bacteria and TNF-α expression significantly decreased in Group E as compared with Group C. Conclusions： The bacterial translocation and the expression of TNF-α in the small intestine exist 24 h after fluid resuscitation. 6 % hydroxyethyl starch can improve the intestinal mucosa barrier function better than the Ringer＇ s solution.展开更多
文摘目的:探究非同型血输注在急救低血容性休克患者中的临床疗效及安全性,以期为提高急救低血容性休克患者的抢救成功率提供参考借鉴。方法:选取2017年9~2020年9月收治的因低血容性休克而需紧急输血的52例患者作为研究对象,遵循随机抽样原则将患者分为对照组26例以及治疗组26例。其中,对照组患者遵循急诊输血流程输注与患者血型相合,配血相容的血液,治疗组患者紧急进行O型血输注抢救。通过比较两组患者抢救成功率、等候时间以及输血前后总胆红素(TBIL)、间接胆红素(IBIL)和血浆游离血红蛋白(FHb)等指标的差异。结果:对照组患者抢救成功率为50.0%(13/26),治疗组患者的抢救成功率为84.6%(22/26),两组间的差异具有统计学意义(P<0.05)。此外,治疗组患者的等候时间显著低于对照组(17.2±3.2 min VS.48.7±9.0 min,P<0.05)。在输血前后,治疗组与对照组患者TBIL、IBIL以及FHb等指标差异无统计学意义(P>0.05)。结论:非同型血输注能有效提高低血容性休克患者的抢救成功率,缩短患者等候时间,并具有与同型血输注类似的疗效,具有较大的临床应用价值。
文摘Objective： To investigate the effects of two fluid resuscitations on the bacterial translocation and the inflammatory factors of small intestine in rats with hemorrhagic shock. Methods： Fifty SD healthy male rats were randomly divided into 5 groups （ n = 10 per group） ： Group A （ Sham group）, Group B （ Ringer＇ s solution for 1 h ）, Group C （Ringer＇ s solution for 24 h ）, Group D （ hydroxyethyl starch for 1 h ） and Group E （（ hydroxyethyl starch for 24 h）. A model of rats with hemorrhagic shock was established. The bacterial translocation in liver, content of tumor necrosis factor-α （TNF-α） and changes of myeloperoxidase enzyme （MPO） activities in small intestine were pathologically investigated after these two fluid resuscitations, respectively. Results ： The bacterial translocation and the expression of TNF-α in the small intestine were detected at 1 h and 24 h after fluid resuscitation. There were significant increase in the number of translocated bacteria, TNF-α and MPO activities in Group C compared with Group B, significant decrease in Group E compared with Group D and in Group B compared with Group D. The number of translocated bacteria and TNF-α expression significantly decreased in Group E as compared with Group C. Conclusions： The bacterial translocation and the expression of TNF-α in the small intestine exist 24 h after fluid resuscitation. 6 % hydroxyethyl starch can improve the intestinal mucosa barrier function better than the Ringer＇ s solution.
