Fragile X syndrome （FXS） is one of the most prevalent mental retardations. It is mainly caused by the loss of fragile X mental retardation protein （FMRP）. FMRP is an RNA binding protein and can regulate the transl...Fragile X syndrome （FXS） is one of the most prevalent mental retardations. It is mainly caused by the loss of fragile X mental retardation protein （FMRP）. FMRP is an RNA binding protein and can regulate the translation of its binding RNA, thus regulate several signaling pathways. Many FXS patients show high susceptibility to epilepsy. Epilepsy is a chronic neurological disorder which is characterized by the recurrent appearance of spontaneous seizures due to neuronal hyperactivity in the brain. Both the abnormal activation of several signaling pathway and morphological abnormality that are caused by the loss of FMRP can lead to a high susceptibility to epilepsy. Combining with the research progresses on both FXS and epilepsy, we outlined the possible mechanisms of high susceptibility to epilepsy in FXS and tried to give a prospect on the future research on the mechanism of epilepsy that happened in other mental retardations.展开更多
Based on the sticking point of the low intelligence of the existing management decision system,this paper puts forward the idea of enriching and refining the knowledge of the system and endowing it with the ability to...Based on the sticking point of the low intelligence of the existing management decision system,this paper puts forward the idea of enriching and refining the knowledge of the system and endowing it with the ability to learn by means of adopting three types of heterogeneous knowledge representation and knowledge management measures.At length,this paper outlines the basic framework of an intelligence system for the sake of management decision problem.展开更多
In some countries, there exists a risk of power deficit in the EPS （electrical power system）. This is a very serious problem and there are various solutions to deal with it. A power deficit in the EPS leads to frequ...In some countries, there exists a risk of power deficit in the EPS （electrical power system）. This is a very serious problem and there are various solutions to deal with it. A power deficit in the EPS leads to frequency decrease in the power system. A dedicated automation to load shedding is used to maintain proper EPS operation. For some time, it has applied a mechanism called demand-side response, which in case of an emergency situation allows for a ＂more civilized＂ rationing of electricity to customers, with their consent. Such programs require that the utilities pay the customers for their agreement. The author proposes a new solution, intermediate between strict ALS （acting relieving automation） and demand-side response programs, where the companies have to send information about the price of energy or control signals to households.展开更多
Objective To explore the therapeutic efficacy and mechanism of acupuncture at Lieque （列缺 LU 7） in treatment of cervical vertigo （CV）. Methods Forty CV patients met the inclusion criteria were enrolled and treate...Objective To explore the therapeutic efficacy and mechanism of acupuncture at Lieque （列缺 LU 7） in treatment of cervical vertigo （CV）. Methods Forty CV patients met the inclusion criteria were enrolled and treated with acupuncture at bilateral LU 7 points, once daily with 10 times as a course. The changes of blood flow velocity in bilateral vertebral artery and basilar artery were observed through transcranial doppler sonography （TCD） before treatment, after deqi with acupuncture and after a course of treatment, respectively. The scores and therapeutic efficacy on clinical symptoms were assessed according to CV symptoms and the functional assessment scale as well as the Criteria-for Diagnosis and Curative Effect in TCM Syndromes before treatment and after a course of treatment. Results Before treatment, after deqi and after a course of treatment, the blood flow velocity of basilar artery （BA）, left vertebral artery （LVA） and right vertebral artery （RVA） in 22 patients with a decreased blood flow velocity were respectively 23.20±4.84 vs 26.30 ± 4.17 vs 29.20 ± 4.20 （mm/s, BA）, 21.65 ± 3.62 vs 24.20 ± 2.89 vs 26.40 ± 3.62 （mm/s, LVA） and 21.90±3.04 vs 24.25±3.01 vs 26.50_±3.95 （mm/s, RVA）, while in 18 patients with an increased blood flow velocity were respectively 39.94 ± 8.24 vs 35.17 ± 4.84 vs 32.06 ± 3.49 （mm/s, BA）, 41.83 ± 5.64 vs 37.28 ± 2.32 vs 35.61 ± 2.09 （mm/s, LVA） and 37.11 ± 9.83 vs 32.22 ± 6.13 vs 28.11 ± 4.12 （mm/s, RVA）. Except that the difference of blood flow velocity of RVA was not significant in patients with an increased blood flow velocity before treatment and after deqi （P 〉 0.05）, the Vm of all vessels in 40 patients was improved after deqi with acupuncture and a course of treatment （P〈0.01, P〈0.05）. According to CV symptoms and the functional assessment scale, before treatment and after a course of treatment, the scores were 15.68 ± 5.35 and 26.30 ± 3.76, respectively, indicating that after a course of treatment, the symptoms were significantly improved （P 〈 0.01）. According to the Criteria for Diagnosis and Curative E.f]ect in TCM Syndromes, after a course of treatment, the total effective rate was 100% （40/40） and the cured rate was 55.0% （22/40）. Conclusion Acupuncture at LU 7 not only improves the blood supply of vertebral-basilar artery in CV patients, but also has a significant curative effect on improving the clinical symptoms.展开更多
Objective To observe clinical efficacy of acupuncture at ]ing-well point combined with educational training for the treatment of children with severe mental retardation. Methods Sixty children with severe mental retar...Objective To observe clinical efficacy of acupuncture at ]ing-well point combined with educational training for the treatment of children with severe mental retardation. Methods Sixty children with severe mental retardation were randomly divided into ]ing-well point acupuncture plus simple special education and language training group （group A） and simple special education and language training group （group B） with 30 child patients in each group according to registration order. All the patients were treated once every other day, 10 times as a course of treatment. There were 20 days of interval between each course of treatment. Curative effect was analyzed after 3 courses of treatment. Gesell Developmental Scale test was conducted for all children before and after treatment. Development quotient at the functional area of social adaptability, large motor, fine motor, language skill and social behavior of individuals was recorded and compared between groups and before and after treatment to evaluate the curative effect. Results Social adaptability and fine motor of children were improved in the group B after treatment. And in the group A, social adaptability, fine motor, language skill and social behavior of individuals were improved after treatment. Meanwhile, the group A was superior to the group B in curative effect of overall social adaptability and language skill （both P〈0.05）. The overall response rate in group B was 23.3% （7/30） and in group A was 46.6% （14/30, P〈0.05）. Conclusion Acupuncture at jing-well point combined with educational training can effectively improve the intelligence level of children with severe mental retardation and its curative effect is better than that of simply education and training.展开更多
Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photore- ceptors. The major fly rhodopsin, Rhl, undergoes light-induced endocytosis and degr...Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photore- ceptors. The major fly rhodopsin, Rhl, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how translation of Rhl is regulated. Here, we show that adult photorecep- tors maintain a constant, abundant quantity of ninaE mRNA, which encodes Rhl. We demonstrate that the Fmrl protein associ- ates with ninaE mRNA and represses its translation. Further, light exposure triggers a calcium-dependent dephosphorylation of Fmrl, which relieves suppression of Rhl translation. We demonstrate that Mts, the catalytic subunit of protein phosphatase 2A （PP2A）, mediates light-induced Fmrl dephosphorylation in a regulatory B subunit of PP2A （CKa）-dependent manner. Finally, we show that blocking light-induced Rhl translation results in reduced light sensitivity. Our results reveal the molecular mechanism of Rhl homoeostasis and physiological consequence of Rhl dysregulation.展开更多
文摘Fragile X syndrome （FXS） is one of the most prevalent mental retardations. It is mainly caused by the loss of fragile X mental retardation protein （FMRP）. FMRP is an RNA binding protein and can regulate the translation of its binding RNA, thus regulate several signaling pathways. Many FXS patients show high susceptibility to epilepsy. Epilepsy is a chronic neurological disorder which is characterized by the recurrent appearance of spontaneous seizures due to neuronal hyperactivity in the brain. Both the abnormal activation of several signaling pathway and morphological abnormality that are caused by the loss of FMRP can lead to a high susceptibility to epilepsy. Combining with the research progresses on both FXS and epilepsy, we outlined the possible mechanisms of high susceptibility to epilepsy in FXS and tried to give a prospect on the future research on the mechanism of epilepsy that happened in other mental retardations.
基金The paper is supported by National Natural Science Foundation of China (No 70271002)
文摘Based on the sticking point of the low intelligence of the existing management decision system,this paper puts forward the idea of enriching and refining the knowledge of the system and endowing it with the ability to learn by means of adopting three types of heterogeneous knowledge representation and knowledge management measures.At length,this paper outlines the basic framework of an intelligence system for the sake of management decision problem.
文摘In some countries, there exists a risk of power deficit in the EPS （electrical power system）. This is a very serious problem and there are various solutions to deal with it. A power deficit in the EPS leads to frequency decrease in the power system. A dedicated automation to load shedding is used to maintain proper EPS operation. For some time, it has applied a mechanism called demand-side response, which in case of an emergency situation allows for a ＂more civilized＂ rationing of electricity to customers, with their consent. Such programs require that the utilities pay the customers for their agreement. The author proposes a new solution, intermediate between strict ALS （acting relieving automation） and demand-side response programs, where the companies have to send information about the price of energy or control signals to households.
文摘Objective To explore the therapeutic efficacy and mechanism of acupuncture at Lieque （列缺 LU 7） in treatment of cervical vertigo （CV）. Methods Forty CV patients met the inclusion criteria were enrolled and treated with acupuncture at bilateral LU 7 points, once daily with 10 times as a course. The changes of blood flow velocity in bilateral vertebral artery and basilar artery were observed through transcranial doppler sonography （TCD） before treatment, after deqi with acupuncture and after a course of treatment, respectively. The scores and therapeutic efficacy on clinical symptoms were assessed according to CV symptoms and the functional assessment scale as well as the Criteria-for Diagnosis and Curative Effect in TCM Syndromes before treatment and after a course of treatment. Results Before treatment, after deqi and after a course of treatment, the blood flow velocity of basilar artery （BA）, left vertebral artery （LVA） and right vertebral artery （RVA） in 22 patients with a decreased blood flow velocity were respectively 23.20±4.84 vs 26.30 ± 4.17 vs 29.20 ± 4.20 （mm/s, BA）, 21.65 ± 3.62 vs 24.20 ± 2.89 vs 26.40 ± 3.62 （mm/s, LVA） and 21.90±3.04 vs 24.25±3.01 vs 26.50_±3.95 （mm/s, RVA）, while in 18 patients with an increased blood flow velocity were respectively 39.94 ± 8.24 vs 35.17 ± 4.84 vs 32.06 ± 3.49 （mm/s, BA）, 41.83 ± 5.64 vs 37.28 ± 2.32 vs 35.61 ± 2.09 （mm/s, LVA） and 37.11 ± 9.83 vs 32.22 ± 6.13 vs 28.11 ± 4.12 （mm/s, RVA）. Except that the difference of blood flow velocity of RVA was not significant in patients with an increased blood flow velocity before treatment and after deqi （P 〉 0.05）, the Vm of all vessels in 40 patients was improved after deqi with acupuncture and a course of treatment （P〈0.01, P〈0.05）. According to CV symptoms and the functional assessment scale, before treatment and after a course of treatment, the scores were 15.68 ± 5.35 and 26.30 ± 3.76, respectively, indicating that after a course of treatment, the symptoms were significantly improved （P 〈 0.01）. According to the Criteria for Diagnosis and Curative E.f]ect in TCM Syndromes, after a course of treatment, the total effective rate was 100% （40/40） and the cured rate was 55.0% （22/40）. Conclusion Acupuncture at LU 7 not only improves the blood supply of vertebral-basilar artery in CV patients, but also has a significant curative effect on improving the clinical symptoms.
基金Supported by Foshan Medical Key Science and Technology Project,F.K.[2013]No.79,project number 201308181
文摘Objective To observe clinical efficacy of acupuncture at ]ing-well point combined with educational training for the treatment of children with severe mental retardation. Methods Sixty children with severe mental retardation were randomly divided into ]ing-well point acupuncture plus simple special education and language training group （group A） and simple special education and language training group （group B） with 30 child patients in each group according to registration order. All the patients were treated once every other day, 10 times as a course of treatment. There were 20 days of interval between each course of treatment. Curative effect was analyzed after 3 courses of treatment. Gesell Developmental Scale test was conducted for all children before and after treatment. Development quotient at the functional area of social adaptability, large motor, fine motor, language skill and social behavior of individuals was recorded and compared between groups and before and after treatment to evaluate the curative effect. Results Social adaptability and fine motor of children were improved in the group B after treatment. And in the group A, social adaptability, fine motor, language skill and social behavior of individuals were improved after treatment. Meanwhile, the group A was superior to the group B in curative effect of overall social adaptability and language skill （both P〈0.05）. The overall response rate in group B was 23.3% （7/30） and in group A was 46.6% （14/30, P〈0.05）. Conclusion Acupuncture at jing-well point combined with educational training can effectively improve the intelligence level of children with severe mental retardation and its curative effect is better than that of simply education and training.
文摘Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photore- ceptors. The major fly rhodopsin, Rhl, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how translation of Rhl is regulated. Here, we show that adult photorecep- tors maintain a constant, abundant quantity of ninaE mRNA, which encodes Rhl. We demonstrate that the Fmrl protein associ- ates with ninaE mRNA and represses its translation. Further, light exposure triggers a calcium-dependent dephosphorylation of Fmrl, which relieves suppression of Rhl translation. We demonstrate that Mts, the catalytic subunit of protein phosphatase 2A （PP2A）, mediates light-induced Fmrl dephosphorylation in a regulatory B subunit of PP2A （CKa）-dependent manner. Finally, we show that blocking light-induced Rhl translation results in reduced light sensitivity. Our results reveal the molecular mechanism of Rhl homoeostasis and physiological consequence of Rhl dysregulation.
