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可注射磁性液固相变材料用于骨肉瘤的磁共振成像与低温磁热治疗研究 被引量:1
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作者 徐东 朱钰方 +2 位作者 郑元义 罗宇 陈航榕 《无机材料学报》 SCIE EI CAS CSCD 北大核心 2020年第11期1277-1282,共6页
过高温可诱发肿瘤周围正常组织产生炎症以及热辐射损伤。因此研发一种能在相对较低温度下(例如43℃)即可实现肿瘤细胞高致死率的磁性材料对于磁热治疗的临床应用至关重要。本研究聚焦低温、安全、高效磁热疗,选取FDA批准的液固相变材料... 过高温可诱发肿瘤周围正常组织产生炎症以及热辐射损伤。因此研发一种能在相对较低温度下(例如43℃)即可实现肿瘤细胞高致死率的磁性材料对于磁热治疗的临床应用至关重要。本研究聚焦低温、安全、高效磁热疗,选取FDA批准的液固相变材料聚乳酸–羟基乙酸(PLGA)为原料,装载一步温和还原法制备得到的超顺磁性氧化铁纳米颗粒,用于磁共振成像和磁热升温;进一步在PLGA中装载热休克蛋白HSP90的小分子抑制剂–表没食子儿茶素没食子酸酯(EGCG),抑制机体受热保护功能,实现较低温度下杀死肿瘤细胞。体外实验结果表明,制备得到的超顺磁性氧化铁纳米颗粒不仅拥有良好的T2加权成像性能,还具有优良的磁热升温性能。所制备的PLGA/Fe3O4/EGCG复合材料在交变磁场下控制升温至43℃并保温40 min后发现肿瘤细胞死亡率达70%,显示出针对骨肉瘤低温磁热治疗的良好潜力。这种可注射磁热相变材料将为骨肉瘤的治疗提供新的思路和材料支撑。 展开更多
关键词 可注射 液固相变 低温磁热 共振成像 骨肉瘤
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Effects of magnetic field and hot rolling on microstructures and properties of cryo ECAPed 1050 aluminum alloy during annealing 被引量:3
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作者 曹以恒 何立子 +3 位作者 张林 周亦胄 王平 崔建忠 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2016年第3期620-626,共7页
The evolution of hardness and microstructures of 1050 aluminum alloy prepared by hot rolling and subsequent equal- channel angular pressing at cryogenic temperature (cryoECAP) after annealing at 150?400 °C for 1 ... The evolution of hardness and microstructures of 1050 aluminum alloy prepared by hot rolling and subsequent equal- channel angular pressing at cryogenic temperature (cryoECAP) after annealing at 150?400 °C for 1 h without and with magnetic field of 12 T was investigated. The electron back scattering diffraction pattern (EBSD) and transmission electron microscopy (TEM) were utilized to characterize the grain microstructures and dislocations. It is demonstrated that the hot rolling before cryoECAP produces more equiaxed grains with a smaller average size and a higher fraction of high angle boundaries (HABs) in the subsequent cryoECAPed 1050 aluminum alloy, thus accelerating the recovery and recrystallization of cryoECAPed alloy and produces more homogeneous microstructure during annealing. The magnetic field promotes the recovery and recrystallization and leads to much lower hardness at 150?250 °C, while it can suppress the abnormal grain growth and form more homogeneous grain size distributions annealed at 300?400 °C. 展开更多
关键词 1050 aluminum alloy magnetic annealing hot rolling cryoECAP HARDNESS grain growth
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ZnO-PCBM bilayers as electron transport layers in low-temperature processed perovskite solar cells 被引量:4
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作者 Jiaqi Zhang Ching Hong Tan +5 位作者 Tian Du Maurizio Morbidoni Chieh-Ting Lin Shengda Xu James R.Durrant Martyn A.McLachlan 《Science Bulletin》 SCIE EI CSCD 2018年第6期343-348,共6页
We investigate an electron transport bilayer fabricated at 〈110℃ to form all low-temperature processed, thermally stable, efficient perovskite solar cells with negligible hysteresis. The components of the bilayer cr... We investigate an electron transport bilayer fabricated at 〈110℃ to form all low-temperature processed, thermally stable, efficient perovskite solar cells with negligible hysteresis. The components of the bilayer create a symbiosis that results in improved devices compared with either of the components being used in isolation. A sol-gel derived ZnO layer facilitates improved energy level alignment and enhanced charge carrier extraction and a [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) layer to reduce hysteresis and enhance perovskite thermal stability. The creation of a bilayer structure allows materials that are inherently unsuitable to be in contact with the perovskite active layer to be used in efficient devices through simple surface modification strategies. 展开更多
关键词 Hybrid perovskite Solar cell Electron transport layer Metal oxide
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Low-temperature heat transport of spin-gapped quantum magnets
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作者 Xia Zhao ZhiYing Zhao +1 位作者 XuGuang Liu XueFeng Sun 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2016年第11期1-16,共16页
This article reviews low-temperature heat transport studies of spin-gapped quantum magnets in the last few decades. Quantum magnets with small spins and low dimensionality exhibit a variety of novel phenomena. Among t... This article reviews low-temperature heat transport studies of spin-gapped quantum magnets in the last few decades. Quantum magnets with small spins and low dimensionality exhibit a variety of novel phenomena. Among them, some systems are characteristic of having quantum-mechanism spin gap in their magnetic excitation spectra, including spin-Peierls systems, S=1Haldane chains, S= 1/2 spin ladders, and spin dimmers. In some particular spin-gapped systems, the XY-type antiferromagnetic state induced by magnetic field that closes the spin gap can be described as a magnon Bose-Einstein condensation(BEC). Heat transport is effective in probing the magnetic excitations and magnetic phase transitions, and has been extensively studied for the spin-gapped systems. A large and ballistic spin thermal conductivity was observed in the two-leg Heisenberg S=1/2 ladder compounds. The characteristic of magnetic thermal transport of the Haldane chain systems is quite controversial on both the theoretical and experimental results. For the spin-Peierls system, the spin excitations can also act as heat carriers. In spin-dimer compounds, the magnetic excitations mainly play a role of scattering phonons. The magnetic excitations in the magnon BEC systems displayed dual roles, carrying heat or scattering phonons, in different materials. 展开更多
关键词 heat transport quantum magnets spin gap
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