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低纤型1790dtex/2锦纶66浸胶帘布在轻型载重斜交轮胎中的应用
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作者 曲良硕 宋耀武 《现代橡胶技术》 2003年第5期14-16,共3页
对低纤型1790dtex/2锦纶66浸胶帘布在轻型载重斜交轮胎中的应用进行了研究。结果表明,低纤型1790dtex/2锦纶66浸胶帘布代替1870dtex/2锦纶66浸胶帘布使用,在保证轮胎质量的前提下,可以明显降低轮胎的生产成本。
关键词 低纤型 锦纶66浸胶帘布 载重斜交轮胎 压穿强度 耐久性能
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miR-222调控PARP-1在高糖致人肾脏系膜细胞tPA/PAI-1紊乱中的作用 被引量:1
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作者 朱恒梅 祝胜郎 +2 位作者 陈结慧 杨芸 李金艳 《新医学》 2018年第7期502-506,共5页
目的探讨微小RNA-222(miR-222)调控多聚二磷酸腺苷核糖聚合酶-1(PARP-1)在高糖诱导人肾脏系膜细胞(HMC)组织型纤溶酶原激活物/纤溶酶原激活物抑制物-1(tPA/PAI-1)紊乱中的作用。方法体外培养HMC,实时定量PCR分别检测正常糖(5 mmol/L)及... 目的探讨微小RNA-222(miR-222)调控多聚二磷酸腺苷核糖聚合酶-1(PARP-1)在高糖诱导人肾脏系膜细胞(HMC)组织型纤溶酶原激活物/纤溶酶原激活物抑制物-1(tPA/PAI-1)紊乱中的作用。方法体外培养HMC,实时定量PCR分别检测正常糖(5 mmol/L)及高糖(25 mmol/L)刺激下miR-222表达;另将体外培养的HMC分为正常糖组、25 mmol/L高糖组、高糖+miR-222 mimics阴性对照组、高糖+miR-222 mimics组4组,运用蛋白免疫印迹法检测PARP-1蛋白表达,ELISA法测定细胞上清液tPA、PAI-1的分泌蛋白。结果实时定量PCR显示,高糖组HMC在24 h时miR-222mRNA表达水平是正常糖组的2.537倍。高糖组HMC中PARP-1蛋白表达高于正常糖组(P<0.05),高糖+miR-222 mimics组HMC中PARP-1蛋白表达低于高糖组(P<0.05),而高糖+miR-222 mimics阴性对照组与高糖组比较差异无统计学意义(P>0.05)。与正常糖组比较,高糖组的tPA和tPA/PAI-1降低、PAI-1升高(P均<0.05);与高糖组比较,高糖+mimics组的tPA和tPA/PAI-1升高、PAI-1降低(P均<0.05)。高糖+miR-222 mimics阴性对照组与高糖组tPA、PAI-1及tPA/PAI-1比较差异均无统计学意义(P均>0.05)。结论高糖可增强HMC PARP-1及分泌型PAI-1的蛋白表达、减弱分泌型tPA的蛋白表达,下调tPA/PAI-1比值。miR-222可有效下调靶蛋白PARP-1的表达,并有效改善高糖诱导的tPA/PAI-1紊乱。 展开更多
关键词 微小核糖核酸-222 多聚二磷酸腺苷核糖聚合酶-1 组织溶酶原激活物/溶酶原激活物抑制物-1
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Structural behaviour of fibre metal laminates subjected to a low velocity impact 被引量:2
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作者 CANTWELL W J 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第6期1168-1177,共10页
Structural impact tests were first presented to cover typical fibre metal laminates (FMLs) subjected a low velocity projectile impact,which produced the corresponding load-displacement traces and deformation/failure m... Structural impact tests were first presented to cover typical fibre metal laminates (FMLs) subjected a low velocity projectile impact,which produced the corresponding load-displacement traces and deformation/failure modes for the validation of numerical models.Finite element (FE) models were then developed to simulate the impact behaviour of FMLs tested.The aluminium (alloy grade 2024-0) layer was modelled as an isotropic elasto-plastic material up to the on-set of post failure stage,followed by shear failure and tensile failure to simulate its failure mechanisms.The glass fibre laminate (woven glass-fibre reinforced composite) layer was modelled as an orthotropic material up to its on-set of damage,followed by damage initiation and evolution using the Hashin criterion.The damage initiation was controlled by failure tensile and compressive stresses within the lamina plane which were primarily determined by tests.The damage evolution was controlled by tensile/compressive fracture energies combined with both fibre and matrix.The FE models developed for the 2/1,3/2 and 4/3 FMLs plates made with 4-ply and 8-ply glass fibre laminate cores were validated against the corresponding experimental results.Good correlation was obtained in terms of load-displacement traces,deformation and failure modes.The validated models were ready to be used to undertake parametric studies to cover FMLs plates made with various stack sequences and composite cores. 展开更多
关键词 DAMAGE Hashin criterion finite element IMPACT FMLs progressive failure
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