Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods...Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods： 140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size, necrosis or cyst formation, radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated. Results： The efficiency rate was 84.3%. The salient efficiency rates were 54.3% for total and 30%, 36.4%, 50%, 68%, 69.2%, and 73.1% for segmenting, respectively. Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation. Radiation-induced oedema occurred for 32.7%. The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like. Conclusion： Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma. The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up. Radiobiological effect affect the efficacy evaluation. MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.展开更多
基金Guangzhou Medical Science Project (No. 2006-YB-169)
文摘Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods： 140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size, necrosis or cyst formation, radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated. Results： The efficiency rate was 84.3%. The salient efficiency rates were 54.3% for total and 30%, 36.4%, 50%, 68%, 69.2%, and 73.1% for segmenting, respectively. Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation. Radiation-induced oedema occurred for 32.7%. The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like. Conclusion： Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma. The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up. Radiobiological effect affect the efficacy evaluation. MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.
