Hypocholesterolemia is characterized by serum total cholesterol that is lower than the 5th percentile for age and sex,or the cut-off value which predicts the adverse prognosis by epidemiological study.Unlike hypercho-...Hypocholesterolemia is characterized by serum total cholesterol that is lower than the 5th percentile for age and sex,or the cut-off value which predicts the adverse prognosis by epidemiological study.Unlike hypercho-lesterolemia,physicians pay less attention to the morbidity,causes and consequences of hypocholesterolemia in clinical practice.In fact,hypocholesterolemia is a common dislipidemia,and mainly results from secondary factors.The causes of primary hypocholesterolemia are some disorders owing to genetic mutation in the pathway of cholesterol absorption,biosynthesis or metabolism,including abetalipoproteinemia,hypobetalipoproteinemia,Tangier disease,chylomicron retention disease and inherited disorders of cholesterol biosynthesis.The causes of secondary hypocholesterolemia comprise anemia,hyperthyroidism,malignancy,live disease,critical illness,serious stress,malabsorption or malnutrition,acute or chronic infection,chronic inflammation,and use of some drugs.In addition,what’s more important is that hypocholesterolemia can result in some adverse events,such as increased mortality,intracerebral hemorrhage,cancer,infection,adrenal failure,suicide and mental disorder.Therefore,with the practice of intensive lipid-lowering treatment and the tendency to the increased indications of statins,it’s high time that physicians attached more importance to hypocholesterolemia.展开更多
目的分析多发性骨髓瘤(MM)患者低胆固醇血症与临床指标、临床分期、细胞遗传学异常之间的相关性,探讨低胆固醇血症发生的原因及可能机制。方法采用单因素及多因素线性分析法回顾性分析了154例确诊的MM患者血清胆固醇水平与血红蛋白、骨...目的分析多发性骨髓瘤(MM)患者低胆固醇血症与临床指标、临床分期、细胞遗传学异常之间的相关性,探讨低胆固醇血症发生的原因及可能机制。方法采用单因素及多因素线性分析法回顾性分析了154例确诊的MM患者血清胆固醇水平与血红蛋白、骨髓瘤细胞比例、临床分期及遗传学异常之间的相关性;采用实时荧光定量PCR检测初诊、完全缓解MM患者与胆固醇转运及胞内定位相关的低密度脂蛋白受体(LDLR)及三磷酸腺苷相关转运体ABCA1m RNA的表达水平。结果 MM患者血清胆固醇水平下降以低密度脂蛋白(LDL)和载脂蛋白B最为显著,且随疾病分期逐渐降低;胆固醇水平与患者遗传学异常具有一定相关性,荧光原位杂交技术(FISH)检测1q21扩增和p53缺失患者血清胆固醇水平显著低于FISH阴性的患者。LDLR m RNA在初诊和复发MM患者中的表达水平明显高于完全缓解组及对照组(P=0.001),而ABCA1 m RNA在各组间无统计学差异。结论 MM患者胆固醇降低的水平与临床分期、遗传学异常相关;MM患者的低胆固醇血症可能与LDL摄入增加有关,而胆固醇逆向转运并无显著变化。展开更多
文摘Hypocholesterolemia is characterized by serum total cholesterol that is lower than the 5th percentile for age and sex,or the cut-off value which predicts the adverse prognosis by epidemiological study.Unlike hypercho-lesterolemia,physicians pay less attention to the morbidity,causes and consequences of hypocholesterolemia in clinical practice.In fact,hypocholesterolemia is a common dislipidemia,and mainly results from secondary factors.The causes of primary hypocholesterolemia are some disorders owing to genetic mutation in the pathway of cholesterol absorption,biosynthesis or metabolism,including abetalipoproteinemia,hypobetalipoproteinemia,Tangier disease,chylomicron retention disease and inherited disorders of cholesterol biosynthesis.The causes of secondary hypocholesterolemia comprise anemia,hyperthyroidism,malignancy,live disease,critical illness,serious stress,malabsorption or malnutrition,acute or chronic infection,chronic inflammation,and use of some drugs.In addition,what’s more important is that hypocholesterolemia can result in some adverse events,such as increased mortality,intracerebral hemorrhage,cancer,infection,adrenal failure,suicide and mental disorder.Therefore,with the practice of intensive lipid-lowering treatment and the tendency to the increased indications of statins,it’s high time that physicians attached more importance to hypocholesterolemia.
文摘目的分析多发性骨髓瘤(MM)患者低胆固醇血症与临床指标、临床分期、细胞遗传学异常之间的相关性,探讨低胆固醇血症发生的原因及可能机制。方法采用单因素及多因素线性分析法回顾性分析了154例确诊的MM患者血清胆固醇水平与血红蛋白、骨髓瘤细胞比例、临床分期及遗传学异常之间的相关性;采用实时荧光定量PCR检测初诊、完全缓解MM患者与胆固醇转运及胞内定位相关的低密度脂蛋白受体(LDLR)及三磷酸腺苷相关转运体ABCA1m RNA的表达水平。结果 MM患者血清胆固醇水平下降以低密度脂蛋白(LDL)和载脂蛋白B最为显著,且随疾病分期逐渐降低;胆固醇水平与患者遗传学异常具有一定相关性,荧光原位杂交技术(FISH)检测1q21扩增和p53缺失患者血清胆固醇水平显著低于FISH阴性的患者。LDLR m RNA在初诊和复发MM患者中的表达水平明显高于完全缓解组及对照组(P=0.001),而ABCA1 m RNA在各组间无统计学差异。结论 MM患者胆固醇降低的水平与临床分期、遗传学异常相关;MM患者的低胆固醇血症可能与LDL摄入增加有关,而胆固醇逆向转运并无显著变化。
