In this report, the author describes and compares two innovative processes for producing thermal energy based on cavitation and nuclear fusion reactions in the indoor environment. Experiments conducted in the laborato...In this report, the author describes and compares two innovative processes for producing thermal energy based on cavitation and nuclear fusion reactions in the indoor environment. Experiments conducted in the laboratory IHS （Intensive Heating System） of IE ＂Revinov N. M.＂ indicate that the process of lasso-vortex cavitation, which generates by means of an electric arc obtained HV-EI, gas-liquid plasma state in the EHH-CTC （electro-hydraulic heater with cavitation thermal camera） is not inferior and sometimes even superior in heat transfer to NF-AC （nuclear fusion reactions in ambient conditions）.展开更多
The tyrosine kinase receptor vascular endothelial growth factor receptor 2 （VEG FR2） is a key regulator of angiogenesis. Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues formi...The tyrosine kinase receptor vascular endothelial growth factor receptor 2 （VEG FR2） is a key regulator of angiogenesis. Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop. These modifications are under dynamic control of the acetyltransferase p300 and two deacetyiases HDAC5 and HDAC6. We demonstrate that VEGFR2 acetylation essentially regulates receptor phosphorylation. In par- ticular, VEGFR2 acetylation significantly alters the kinetics of receptor phosphorylation after ligand binding, allowing receptor phos- phoryiation and intraceUular signaling upon proLonged stimulation with VEGF. Molecular dynamics simulations indicate that acetylation of the lysine in the activation loop contributes to the transition to an open active state, in which tyrosine phosphorylation is favored by better exposure of the kinase target residues. These findings indicate that post-translational modification by acetyiation is a critical mechanism that directLy affects VEGFR2 function.展开更多
文摘In this report, the author describes and compares two innovative processes for producing thermal energy based on cavitation and nuclear fusion reactions in the indoor environment. Experiments conducted in the laboratory IHS （Intensive Heating System） of IE ＂Revinov N. M.＂ indicate that the process of lasso-vortex cavitation, which generates by means of an electric arc obtained HV-EI, gas-liquid plasma state in the EHH-CTC （electro-hydraulic heater with cavitation thermal camera） is not inferior and sometimes even superior in heat transfer to NF-AC （nuclear fusion reactions in ambient conditions）.
文摘The tyrosine kinase receptor vascular endothelial growth factor receptor 2 （VEG FR2） is a key regulator of angiogenesis. Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop. These modifications are under dynamic control of the acetyltransferase p300 and two deacetyiases HDAC5 and HDAC6. We demonstrate that VEGFR2 acetylation essentially regulates receptor phosphorylation. In par- ticular, VEGFR2 acetylation significantly alters the kinetics of receptor phosphorylation after ligand binding, allowing receptor phos- phoryiation and intraceUular signaling upon proLonged stimulation with VEGF. Molecular dynamics simulations indicate that acetylation of the lysine in the activation loop contributes to the transition to an open active state, in which tyrosine phosphorylation is favored by better exposure of the kinase target residues. These findings indicate that post-translational modification by acetyiation is a critical mechanism that directLy affects VEGFR2 function.
