Background Little is known about the prevalence oforthostatic hypertension （OHT） and its effect on long-term mortality in the eld- erly. We evaluated the prevalence of OHT and its effect on mortality in hospitalized...Background Little is known about the prevalence oforthostatic hypertension （OHT） and its effect on long-term mortality in the eld- erly. We evaluated the prevalence of OHT and its effect on mortality in hospitalized elderly patients. Methods Out of 1852 patients admit- ted between 31/12/1999 and 31/12/2000 to an acute geriatric ward, 474 patients （48% males） with a mean age of 81.5 ±6.8 years were en- rolled in this study. Blood pressure （BP） was measured three times during the day in a supine and standing position. Patients with at least one increase in systolic or diastolic BP levels upon standing were diagnosed with OHT. Medical history, physical examination and laboratory parameters were retrieved from the medical records. Mortality data until 18th June 2014 were retrieved from the computerized system of the Ministry of the Interior. Results Four hundred and seven patients （86%） were diagnosed with OHT. Those without OHT had a lowerbody mass index and were more likely males, smokers, had a higher rate of Parkinson＇s disease and less congestive heart failure compared with those with OHT. Patients with OHT had a better survival rate than those without OHT （P = 0.024）. Hazard ratios （HRs） for mortality in those with OHT adjusted to age and multiple risk factors were： 0.67 [95% confidence interval （CI）： 0.51-0.87] and 0.73 （95% CI： 0.55-0.97）, respectively; a similar tendency was noticed in a sensitivity analysis by gender. Conclusion Hospitalized elderly patients with OHT had a better survival rate than those without OHT.展开更多
Objective To determine whether autoantibodies against β 1-adrenergic and M 2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino...Objective To determine whether autoantibodies against β 1-adrenergic and M 2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino acids sequence 197-222 and 169-173 of the second extracellular loops of the β 1 and M 2 receptors were used as antigens to screen sera from 265 patients. 188 were congestive heart failure (CHF) patients with different heart diseases, among them 42 were ischemic cardiomyopathy (ICD) and 52 were idiopathic dilated cardiomyopathy (IDCM),44 were hypertensive heart disease (HHD),50 were rheumatic valvular heart disease (RVHD); 77 were controls, among them 36 were simple hypertension and 41 were healthy donors (NC). Results Positive sera for β 1-adrenergic receptor was found in 45.73% (86/188) of CHF patients, while in the controls it was 10.4% (8/77) ( P <0.01); positive sera for M 2-muscarinic receptor in CHF patients was found in 49.5% (99/188), while in the control it was 11.7% (9/77) ( P <0.01). The positive ratio of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors in CHF patients with cardiac function class Ⅱ-Ⅲ (NYHA) were significantly higher than cardiac function class Ⅳ. The average titer of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors of the former was significantly higher than the latter; 56.1% of patients with autoantibodies against β 1-adrenergic receptor had autoantibodies against M 2-muscarinic receptor. Conclusions Autoantibodies against β 1-adrenergic receptor and M 2-muscarinic receptor were found in sera from heart failure patients with different cardiac diseases. We propose that autoantibodies against β 1 and M 2 receptors are not only related to the IDCM, but also to cardiac structural and functional changes.展开更多
Objective To determine whether autoantibodies against β 1-adrenergic and M 2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino...Objective To determine whether autoantibodies against β 1-adrenergic and M 2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino acids sequence 197-222 and 169-173 of the second extracellular loops of the β 1 and M 2 receptors were used as antigens to screen sera from 265 patients. 188 were congestive heart failure (CHF) patients with different heart diseases, among them 42 were ischemic cardiomyopathy (ICD) and 52 were idiopathic dilated cardiomyopathy (IDCM),44 were hypertensive heart disease (HHD),50 were rheumatic valvular heart disease (RVHD); 77 were controls, among them 36 were simple hypertension and 41 were healthy donors (NC). Results Positive sera for β 1-adrenergic receptor was found in 45.73% (86/188) of CHF patients, while in the controls it was 10.4% (8/77) ( P 【0.01); positive sera for M 2-muscarinic receptor in CHF patients was found in 49.5% (99/188), while in the control it was 11.7% (9/77) ( P 【0.01). The positive ratio of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors in CHF patients with cardiac function class Ⅱ-Ⅲ (NYHA) were significantly higher than cardiac function class Ⅳ. The average titer of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors of the former was significantly higher than the latter; 56.1% of patients with autoantibodies against β 1-adrenergic receptor had autoantibodies against M 2-muscarinic receptor. Conclusions Autoantibodies against β 1-adrenergic receptor and M 2-muscarinic receptor were found in sera from heart failure patients with different cardiac diseases. We propose that autoantibodies against β 1 and M 2 receptors are not only related to the IDCM, but also to cardiac structural and functional changes.展开更多
文摘Background Little is known about the prevalence oforthostatic hypertension （OHT） and its effect on long-term mortality in the eld- erly. We evaluated the prevalence of OHT and its effect on mortality in hospitalized elderly patients. Methods Out of 1852 patients admit- ted between 31/12/1999 and 31/12/2000 to an acute geriatric ward, 474 patients （48% males） with a mean age of 81.5 ±6.8 years were en- rolled in this study. Blood pressure （BP） was measured three times during the day in a supine and standing position. Patients with at least one increase in systolic or diastolic BP levels upon standing were diagnosed with OHT. Medical history, physical examination and laboratory parameters were retrieved from the medical records. Mortality data until 18th June 2014 were retrieved from the computerized system of the Ministry of the Interior. Results Four hundred and seven patients （86%） were diagnosed with OHT. Those without OHT had a lowerbody mass index and were more likely males, smokers, had a higher rate of Parkinson＇s disease and less congestive heart failure compared with those with OHT. Patients with OHT had a better survival rate than those without OHT （P = 0.024）. Hazard ratios （HRs） for mortality in those with OHT adjusted to age and multiple risk factors were： 0.67 [95% confidence interval （CI）： 0.51-0.87] and 0.73 （95% CI： 0.55-0.97）, respectively; a similar tendency was noticed in a sensitivity analysis by gender. Conclusion Hospitalized elderly patients with OHT had a better survival rate than those without OHT.
文摘Objective To determine whether autoantibodies against β 1-adrenergic and M 2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino acids sequence 197-222 and 169-173 of the second extracellular loops of the β 1 and M 2 receptors were used as antigens to screen sera from 265 patients. 188 were congestive heart failure (CHF) patients with different heart diseases, among them 42 were ischemic cardiomyopathy (ICD) and 52 were idiopathic dilated cardiomyopathy (IDCM),44 were hypertensive heart disease (HHD),50 were rheumatic valvular heart disease (RVHD); 77 were controls, among them 36 were simple hypertension and 41 were healthy donors (NC). Results Positive sera for β 1-adrenergic receptor was found in 45.73% (86/188) of CHF patients, while in the controls it was 10.4% (8/77) ( P <0.01); positive sera for M 2-muscarinic receptor in CHF patients was found in 49.5% (99/188), while in the control it was 11.7% (9/77) ( P <0.01). The positive ratio of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors in CHF patients with cardiac function class Ⅱ-Ⅲ (NYHA) were significantly higher than cardiac function class Ⅳ. The average titer of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors of the former was significantly higher than the latter; 56.1% of patients with autoantibodies against β 1-adrenergic receptor had autoantibodies against M 2-muscarinic receptor. Conclusions Autoantibodies against β 1-adrenergic receptor and M 2-muscarinic receptor were found in sera from heart failure patients with different cardiac diseases. We propose that autoantibodies against β 1 and M 2 receptors are not only related to the IDCM, but also to cardiac structural and functional changes.
文摘Objective To determine whether autoantibodies against β 1-adrenergic and M 2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino acids sequence 197-222 and 169-173 of the second extracellular loops of the β 1 and M 2 receptors were used as antigens to screen sera from 265 patients. 188 were congestive heart failure (CHF) patients with different heart diseases, among them 42 were ischemic cardiomyopathy (ICD) and 52 were idiopathic dilated cardiomyopathy (IDCM),44 were hypertensive heart disease (HHD),50 were rheumatic valvular heart disease (RVHD); 77 were controls, among them 36 were simple hypertension and 41 were healthy donors (NC). Results Positive sera for β 1-adrenergic receptor was found in 45.73% (86/188) of CHF patients, while in the controls it was 10.4% (8/77) ( P 【0.01); positive sera for M 2-muscarinic receptor in CHF patients was found in 49.5% (99/188), while in the control it was 11.7% (9/77) ( P 【0.01). The positive ratio of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors in CHF patients with cardiac function class Ⅱ-Ⅲ (NYHA) were significantly higher than cardiac function class Ⅳ. The average titer of autoantibodies against β 1-adrenergic and M 2-muscarinic receptors of the former was significantly higher than the latter; 56.1% of patients with autoantibodies against β 1-adrenergic receptor had autoantibodies against M 2-muscarinic receptor. Conclusions Autoantibodies against β 1-adrenergic receptor and M 2-muscarinic receptor were found in sera from heart failure patients with different cardiac diseases. We propose that autoantibodies against β 1 and M 2 receptors are not only related to the IDCM, but also to cardiac structural and functional changes.
