Towards integration of supply chain, manufacturing/production and investment decision making, this paper presents a hierarchical model architecture which contains six sub-models covering the areas of manufacturing con...Towards integration of supply chain, manufacturing/production and investment decision making, this paper presents a hierarchical model architecture which contains six sub-models covering the areas of manufacturing control, production operation, design and revamp, production management, supply chain and investment decision making. Six types of flow, material, energy, information, humanware, partsware and capital are clasified. These flows connect enterprise components/subsystems to formulate system topology and logical structure. Enterprise components/subsystems are abstracted to generic elementary and composite classes. Finally, the model architecture is applied to a management system of an integrated suply chain, and suggestion are made on the usage of the model architecture and further development of the model as well as implementation issues.展开更多
Endocytosis occurs at the cell surface and involves internalization of the plasma membrane （PM） along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milie...Endocytosis occurs at the cell surface and involves internalization of the plasma membrane （PM） along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface. These include nutrient uptake, signaling from cell- surface receptors, and many other processes essential for cell and tissue functioning in metazoans. It is also central to the maintenance of PM lipid and protein homeostasis. There are multiple means of internalization that operate concurrently, at the cell surface. With advancement in high-resolution visualization techniques, it is now possible to track multiple endocytic cargo at the same time, revealing a remarkable diversity of endocytic processes in a single cell. A combination of live cell imaging and efficient genetic manipulations has also aided in understanding the functional hierarchy of molecular players in these mechanisms of internalization. Here we provide an account of various endocytic routes, their mechanisms of operation and occurrence across phyla.展开更多
With the rapid development of the marine economy industry, human exploitation of marine resources is increasing, which is contributing to the growing trend of eutrophication and frequent occurrence of red tide. Accord...With the rapid development of the marine economy industry, human exploitation of marine resources is increasing, which is contributing to the growing trend of eutrophication and frequent occurrence of red tide. Accordingly, investigations of seawater quality have attracted a great deal of attention. This study was conducted to construct a seawater environmental quality assessment model based on the variable fuzzy recognition model. The uncertainty and ambiguity of the seawater quality assessment were then considered, combining the monitoring values of evaluation indicators with the standard values of seawater quality. Laizhou Bay was subsequently selected for a case study. In this study, the correct variable model for different parameters was obtained according to the linear and nonlinear features of evaluation objects. Application of the variable fuzzy recognition model for Laizhou Bay, water quality evaluation and comparison with performance obtained using other approaches revealed that the generated model is more reliable than traditional methods, can more reasonably determine the water quality of various samples, and is more suitable for evaluation of a multi-index, multi-level, nonlinear marine environment system; accordingly, the generated model will be an effective tool for seawater quality evaluation.展开更多
The present study is part of the Executive Scientific Project 2 in the ItalMed Project which aims to elaborate a feasibility study for new transport connections between Italy and Algeria. The main objectives of the st...The present study is part of the Executive Scientific Project 2 in the ItalMed Project which aims to elaborate a feasibility study for new transport connections between Italy and Algeria. The main objectives of the study are to increase the degree of economic integration between the two countries and improve commercial exchanges and direct investments in Algeria by Italian private companies. Moreover, the study tries to promote Italy＇s role as logistic platform for Mediterranean Countries along the east-west and north-south corridors and to improve the capacity of Italian regions to manage international cooperation programs on transport and logistics, finally, to support regional entrepreneurship in the foreign services sector.展开更多
On the basis of analysis of the operating characteristics of SMEs, problems in financial management are pointed out, such as： limited financing channels, lack of internal control systems, weak basic accounting and ba...On the basis of analysis of the operating characteristics of SMEs, problems in financial management are pointed out, such as： limited financing channels, lack of internal control systems, weak basic accounting and backward financial management information construction, and measures like to create a favorable policy and service environment for SMEs through the legal system, to innovate the financial system, to pay attention to nurturing and incentive financial innovation talents, network-building management and to establish related punishment and supervision system, are proposed.展开更多
基金Supported by the National Natural Science Foundation of China (No. 79931000) and The State Major Basic Research Development Program (No. G20000263).
文摘Towards integration of supply chain, manufacturing/production and investment decision making, this paper presents a hierarchical model architecture which contains six sub-models covering the areas of manufacturing control, production operation, design and revamp, production management, supply chain and investment decision making. Six types of flow, material, energy, information, humanware, partsware and capital are clasified. These flows connect enterprise components/subsystems to formulate system topology and logical structure. Enterprise components/subsystems are abstracted to generic elementary and composite classes. Finally, the model architecture is applied to a management system of an integrated suply chain, and suggestion are made on the usage of the model architecture and further development of the model as well as implementation issues.
文摘Endocytosis occurs at the cell surface and involves internalization of the plasma membrane （PM） along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface. These include nutrient uptake, signaling from cell- surface receptors, and many other processes essential for cell and tissue functioning in metazoans. It is also central to the maintenance of PM lipid and protein homeostasis. There are multiple means of internalization that operate concurrently, at the cell surface. With advancement in high-resolution visualization techniques, it is now possible to track multiple endocytic cargo at the same time, revealing a remarkable diversity of endocytic processes in a single cell. A combination of live cell imaging and efficient genetic manipulations has also aided in understanding the functional hierarchy of molecular players in these mechanisms of internalization. Here we provide an account of various endocytic routes, their mechanisms of operation and occurrence across phyla.
基金Supported by the 908 Special Fund of the State Oceanic Administration:the Offshore Marine Environment Quality Evaluation of Liaoning Province(No.LN-908-02-04)the Humanities and Social Science Research Project of Ministry of Education
文摘With the rapid development of the marine economy industry, human exploitation of marine resources is increasing, which is contributing to the growing trend of eutrophication and frequent occurrence of red tide. Accordingly, investigations of seawater quality have attracted a great deal of attention. This study was conducted to construct a seawater environmental quality assessment model based on the variable fuzzy recognition model. The uncertainty and ambiguity of the seawater quality assessment were then considered, combining the monitoring values of evaluation indicators with the standard values of seawater quality. Laizhou Bay was subsequently selected for a case study. In this study, the correct variable model for different parameters was obtained according to the linear and nonlinear features of evaluation objects. Application of the variable fuzzy recognition model for Laizhou Bay, water quality evaluation and comparison with performance obtained using other approaches revealed that the generated model is more reliable than traditional methods, can more reasonably determine the water quality of various samples, and is more suitable for evaluation of a multi-index, multi-level, nonlinear marine environment system; accordingly, the generated model will be an effective tool for seawater quality evaluation.
文摘The present study is part of the Executive Scientific Project 2 in the ItalMed Project which aims to elaborate a feasibility study for new transport connections between Italy and Algeria. The main objectives of the study are to increase the degree of economic integration between the two countries and improve commercial exchanges and direct investments in Algeria by Italian private companies. Moreover, the study tries to promote Italy＇s role as logistic platform for Mediterranean Countries along the east-west and north-south corridors and to improve the capacity of Italian regions to manage international cooperation programs on transport and logistics, finally, to support regional entrepreneurship in the foreign services sector.
文摘On the basis of analysis of the operating characteristics of SMEs, problems in financial management are pointed out, such as： limited financing channels, lack of internal control systems, weak basic accounting and backward financial management information construction, and measures like to create a favorable policy and service environment for SMEs through the legal system, to innovate the financial system, to pay attention to nurturing and incentive financial innovation talents, network-building management and to establish related punishment and supervision system, are proposed.
