目的探讨常用输液条件下连续用药时发生体外配伍变化的原因,为临床安全用药提供预见性护理干预。方法回顾2011年本院主动上报多组医嘱连续静脉输液发生体外配伍变化事件52例,运用根本原因分析法(root cause analysis,RCA),根据药物配伍...目的探讨常用输液条件下连续用药时发生体外配伍变化的原因,为临床安全用药提供预见性护理干预。方法回顾2011年本院主动上报多组医嘱连续静脉输液发生体外配伍变化事件52例,运用根本原因分析法(root cause analysis,RCA),根据药物配伍变化的不同将患者分组,找出近端原因,与2012年进行对比。结果经过护理干预后,2012年连续用药时体外配伍变化实际发生例数明显低于2011年,对比上报率,差异有统计学意义(P<0.05)。结论利用RCA分析连续用药时发生体外配伍变化的原因,有针对性地进行护理干预,能确保护理安全质量的不断提高。展开更多
Traditional Chinese medicines(TCMs)have been used to prevent and treat various diseases for thousands of years.Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing atte...Traditional Chinese medicines(TCMs)have been used to prevent and treat various diseases for thousands of years.Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing attention,especially for the toxicity of herbs.Studies have pointed out the interactions between the active compounds of herbs and transporters in the detoxification process of toxic compounds.Here,we summarize data on five toxic herbs commonly used in TCMs and their related efflux transporters to reduce toxicity to offer a scientific rationale for the compatibility principle of TCMs and provide guidance for the rational clinical use of TCMs.展开更多
文摘目的探讨常用输液条件下连续用药时发生体外配伍变化的原因,为临床安全用药提供预见性护理干预。方法回顾2011年本院主动上报多组医嘱连续静脉输液发生体外配伍变化事件52例,运用根本原因分析法(root cause analysis,RCA),根据药物配伍变化的不同将患者分组,找出近端原因,与2012年进行对比。结果经过护理干预后,2012年连续用药时体外配伍变化实际发生例数明显低于2011年,对比上报率,差异有统计学意义(P<0.05)。结论利用RCA分析连续用药时发生体外配伍变化的原因,有针对性地进行护理干预,能确保护理安全质量的不断提高。
基金We thank for the funding support from the Science and Technology Development Fund,Macao SAR(No.0040/2020/A and No.0075/2019/AMJ).
文摘Traditional Chinese medicines(TCMs)have been used to prevent and treat various diseases for thousands of years.Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing attention,especially for the toxicity of herbs.Studies have pointed out the interactions between the active compounds of herbs and transporters in the detoxification process of toxic compounds.Here,we summarize data on five toxic herbs commonly used in TCMs and their related efflux transporters to reduce toxicity to offer a scientific rationale for the compatibility principle of TCMs and provide guidance for the rational clinical use of TCMs.
