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蚜虫体色多态性及生态进化功能 被引量:7
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作者 李进步 方丽平 +1 位作者 孟玲 李保平 《生态学杂志》 CAS CSCD 北大核心 2014年第5期1404-1412,共9页
体色多态性在蚜虫中普遍存在,是探索生物适应环境机制及生态进化功能的一个优良范式。尽管蚜虫体色多态性被认知已经有两个多世纪,但其内在的机制仍然不甚明了。本文从蚜虫体色多态性的表现形式、体色的组成部分及色素种类、影响体色多... 体色多态性在蚜虫中普遍存在,是探索生物适应环境机制及生态进化功能的一个优良范式。尽管蚜虫体色多态性被认知已经有两个多世纪,但其内在的机制仍然不甚明了。本文从蚜虫体色多态性的表现形式、体色的组成部分及色素种类、影响体色多态的重要因子、体色多态的生态功能及维持体色多态性的机制等方面综述有关研究进展,为进一步研究蚜虫体色分化的内在机理、体色多态的维持机制及体色多态的生态进化功能等提供方向和线索。 展开更多
关键词 蚜虫 体色多态性 进化生态学
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2个纯合体色品系大瓶螺的几何形态测量学研究 被引量:3
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作者 来益同 沈华 +1 位作者 张奕祥 吴岷 《水生态学杂志》 CSCD 北大核心 2016年第2期88-95,共8页
为了探究大瓶螺(Pomacea canaliculata)体色、性别与贝壳形态之间的关系,运用几何形态测量学方法,对来自于人工繁育的F5纯合体色品系37只深褐色个体(26♀♀,11♂♂)、34只黄色个体(14♀♀,20♂♂)贝壳的正壳口观、壳口观、壳顶观进行地... 为了探究大瓶螺(Pomacea canaliculata)体色、性别与贝壳形态之间的关系,运用几何形态测量学方法,对来自于人工繁育的F5纯合体色品系37只深褐色个体(26♀♀,11♂♂)、34只黄色个体(14♀♀,20♂♂)贝壳的正壳口观、壳口观、壳顶观进行地标标点,获得贝壳的形态信息。运用主成分分析和典型变量分析,检测出不同体色、性别个体间的差异。通过各个标点对于相对扭曲的贡献率,探究其形态变化趋势。主成分分析结果表明,不同体色个体的贝壳形态存在着明显差异,正壳口观较壳口观及壳顶观更能体现贝壳差异;而不同体色的贝壳差异均不及相同体色不同性别个体间贝壳的差异。典型变量分析结果通过普氏距离和马氏距离得以反映,所有组别间的马氏距离均有显著性差异,而普氏距离仅在壳顶观的深褐色和黄色雌螺间以及壳顶观的深褐色和黄色雄螺间无显著差异;对正壳口观各标点对相对扭曲的贡献率分析表明,贝壳形态的变化主要集中在壳口上半部,支持不同体色和性别的大瓶螺在贝壳形态上存在显著差异的结论。发掘大瓶螺中所存在的这些差异对探究不同体色个体的适应性差异提供了重要参考,也表明几何形态测量学可以作为贝壳形态研究的有效方法应用于贝类形态学和种群分析等研究中。 展开更多
关键词 大瓶螺 体色多态性 纯合品系 性二态性 几何形态测量学
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Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms 被引量:5
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作者 Francesco La Marra Giuseppe Stinco +4 位作者 Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci 《Cancer Biology & Medicine》 SCIE CAS CSCD 2017年第2期162-175,共14页
Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by ... Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:"F"and"f"for Fok I,"B"and"b"for Bsm I,"A"and"a"for ApaI,and "T"and"t"for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future. 展开更多
关键词 Vitamin D receptor VDR protein expression VDR polymorphism cutaneous melanoma metastatic melanoma skin cancer predictive biomarkers FokI polymorphism
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Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes 被引量:7
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作者 Jacqueline Brown Hannelie Bothma +1 位作者 Robin Veale Pascale Willem 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第24期2909-2923,共15页
AIM: To identify molecular markers shared across South African esophageal squamous cell carcinoma (ESCC) cell lines using o/togenetics, fluorescence in situ hybridization (FISH) and single nucleotide polymorphism... AIM: To identify molecular markers shared across South African esophageal squamous cell carcinoma (ESCC) cell lines using o/togenetics, fluorescence in situ hybridization (FISH) and single nucleotide polymorphism (SNP) array copy number analysis. METHODS: We used conventional cytogenetics, FISH, and multicolor FISH to characterize the chromosomal rearrangements of five ESCC cell lines established in South Africa. The whole genome copy number profile was established from 250K SNP arrays, and data was analyzed with the CNAT 4.0 and GISTIC software. tions involved the following chromosomal regions and genes: 11q13.3 (CCND1, FGF3, FGF4, FGF19, MYEOV), 8q24.21(C-MYC, FAM84B), 11q22.1-q22.3 (B[RC2, BIRC3), 5p15.2 (CTNND2), 3qll.2-q12.2 (MINA) and 18p11.32 (TYMS, YES1). The significant deletions included 1p31.2-p31.1 (CTH, GADD45a, DIRAS3), 2q22.1 (LRPIB), 3p12.1-p14.2 (FHIT), 4q22.1-q32.1 (CASP6, SMAD1), 8p23.2-q11.1 (BNIP3L) and 18q21.1-q21.2 (SMAD4, DCC). The 3p11.2 translocation breakpoint was shared across four cell lines, supporting a role for genes involved at this site, in particular, the EPHA3 gene which has previously been reported to be deleted in ESCC.CONCLUSION: The finding that a significant number of genes that were amplified (FGF3, FGF4, FGF19, CCND1 and C-MYC) or deleted (SFRP2 gene) are involved in the Wnt and fibroblast growth factor signaling pathways, suggests that these pathways may be activated in these cell lines. 展开更多
关键词 ESOPHAGUS CANCER Single nucleotide polymorphism arrays Fluorescent in situ hybridization
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SCANNING AND ANALYSIS OF MISMATCH DISTRIBUTION ON HUMAN GENOME
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作者 QINGYUN WANG YAYUAN XIAO +1 位作者 HAILU CHEN QIN ZOU 《International Journal of Biomathematics》 2012年第3期169-176,共8页
The mismatch distribution is a good descriptive summary statistic that describes the phenomena of population genetics. This article scanned mismatch distribution on human genome with single nucleotide polymorphism (... The mismatch distribution is a good descriptive summary statistic that describes the phenomena of population genetics. This article scanned mismatch distribution on human genome with single nucleotide polymorphism (SNP) data from the International HapMap Project. It is found that the abnormal mismatch distribution could imply some special segments on some chromosomes. One of the segments, on chromosome 8, was proved as an inversion. Other special segments may also imply some special structure on chromo- somes, such as duplication. The conjectures of other segments still need further research. 展开更多
关键词 Population genetics mismatch distribution single nucleotide polymorphism(SNP).
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