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Wnt信号转导及其生物效应 被引量:6
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作者 张平 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2001年第4期415-419,共5页
Wnt蛋白与其下游效应物构成一组重要的信号转导通路 .信号转导过程包括 :Wnt首先激活细胞表面受体佛力子 (FZ) ,活化的FZ将通过Dvl、CKIε抑制糖原合成酶激酶 3β ,继而拮抗 β 链结素( β cat)催毁器的作用 ,使胞浆中 β cat积聚并进... Wnt蛋白与其下游效应物构成一组重要的信号转导通路 .信号转导过程包括 :Wnt首先激活细胞表面受体佛力子 (FZ) ,活化的FZ将通过Dvl、CKIε抑制糖原合成酶激酶 3β ,继而拮抗 β 链结素( β cat)催毁器的作用 ,使胞浆中 β cat积聚并进入核内 .β cat在核内与转录因子LEF TCF协作 ,激活控制胚胎发育和细胞命运的靶基因 ;活化的FZ还经激活JNK及Flamingo来影响细胞骨架的聚合 。 展开更多
关键词 WNT 佛力学 β-链结素 泛素/蛋白酶休 信号转导 生物效应 发育 动物
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Comparative study of static and dynamic parameters of rock for the Xishan Rock Cliff Statue
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作者 Jin JIANG Jin-zhong SUN 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2011年第10期771-781,共11页
Ultrasonic wave testing was applied to investigate the quality and weathering status of rock specimens obtained in two borings situated in the Xishan Buddha rock slope in Taiyuan, China. This paper pays special attent... Ultrasonic wave testing was applied to investigate the quality and weathering status of rock specimens obtained in two borings situated in the Xishan Buddha rock slope in Taiyuan, China. This paper pays special attention to the distribution of bulk density, dynamic parameters and static parameters of rock specimens as well as the relationship between static and dynamic parameters. The results illustrate that the distribution of both parameters is identical along the depth of two drilled holes in the rock slope. When the hole depth increases, the density of rock mass, saturated compression strength and static elastic modulus, dynamic elastic modulus and wave velocity also show increase tendency. The weathering degree in the rock mass ranging from the surface of cliff to the depth of 2.5 m is the highest while the rock mass is unsalted and more rigid when the depth is larger than 3.0 m. The relationship between dynamic elastic modulus, sonic wave velocity and horizontal depth indicates that dynamic elastic modulus is more sensitive than sonic wave velocity. Conversely, by comparing quantity relationship between static elastic modulus and sonic wave velocity, it is found that the composition of rock has a great influence on the relationship between static and dynamic parameters, that is, inequality of rock composition will lead to dispersion and abnormality of the distribution of static and dynamic parameters. 展开更多
关键词 Xishan Buddha Rock mechanics Rock quality Elastic wave velocity Elastic modulus Compression strength Ultrasonic wave testing
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