According to Psychological theories of motivation, sexuality is a biological need which urges to satisfy sexual desire. Though it is not essential for the survival of an individual, it plays a major role in the growth...According to Psychological theories of motivation, sexuality is a biological need which urges to satisfy sexual desire. Though it is not essential for the survival of an individual, it plays a major role in the growth, development, adjustment and well-being. Therefore, sexuality is a common aspect in the existence and it should not be neglected. However, in many religious ethical issues, sexuality had been treated negatively and identified as a barrier for an advanced spiritual life. Even in tribal societies there were some sexual taboos that controlled man's sexual behavior to some extent. Among religious ethical codes, one may find that it had been placed an important position for controlling or completely eliminating sexual behaviors. In modem world, what is evident is that this so called sexual need has been used for many commercial and marketing purposes. Even in advertising field, sexual desire of man is used as a mean of attracting public. Phonograph has become a very profitable illegal professional today. Sexual medicines, drugs and tools are available everywhere in the society. Though sexual education had been included into the curriculum in schools and higher education institutions, the awareness of sexuality among people seems to be in a low level. While biologically man is compelled to fulfill sexual desire internally, it is motivated externally by many social factors. So that not only misconceptions of sexuality, but also misbehaviors of sexuality can be observed in the society today. By examining these current situations of man's sexual behaviors, there is a big need to formulate a sexual ethical code--a code of law with the help of religious teachings. Otherwise these various sexual behaviors may create more and more social and world problems. In this paper, my aim is to examine Buddhist ethics in order to formulate a sexual ethical code.展开更多
Starting from the thesis that translation always takes place in a certain social and cultural context and is therefore conditioned by certain contextual factors, this paper examines the particular role that poetics pl...Starting from the thesis that translation always takes place in a certain social and cultural context and is therefore conditioned by certain contextual factors, this paper examines the particular role that poetics played in Buddhist scripture translation that happened in ancient China. Buddhist poetics, in its associations with China's native poetics, did not work its way peacefully into the latter's embrace, to begin with. Instead, its appearance was first met with severe criticism and resistance. Aware of this problem, Buddhist translators in ancient China made continuous efforts in adapting Buddhist translations to the reading habits of the local people, which helped to ensure an easier acceptance of Buddhist philosophy by the Chinese people. With the growth and advancement of Buddhism in China, Buddhist poetics was no longer regarded as an enemy by its Chinese counterpart, and the style of Buddhist scripture translation was therefore able to stick closer to that of the original texts. The conclusion is that the poetics of one foreign literary system, when it comes to a new cultural environment, instead of remaining unaltered, usually goes through a complicated process of clashing and confl cfing with the native poetics before they two become reconciled and compatible with each other.展开更多
Background and objective:Acute liver failure(ALF)is a type of disease with high mortality and rapid progression with no specific treatment methods currently available.Glucocorticoids exert beneficial clinical effects ...Background and objective:Acute liver failure(ALF)is a type of disease with high mortality and rapid progression with no specific treatment methods currently available.Glucocorticoids exert beneficial clinical effects on therapy for ALF.However,the mechanism of this effect remains unclear and when to use glucocorticoids in patients with ALF is difficult to determine.The purpose of this study was to investigate the specific immunological mechanism of dexamethasone(Dex)on treatment of ALF induced by lipopolysaccharide(LPS)/D-galactosamine(D-Ga IN)in mice.Methods:Male C57 BL/6 mice were given LPS and D-Ga IN by intraperitoneal injection to establish an animal model of ALF.Dex was administrated to these mice and its therapeutic effect was observed.Hematoxylin and eosin(H&E)staining was used to determine liver pathology.Multicolor flow cytometry,cytometric bead array(CBA)method,and next-generation sequencing were performed to detect changes of messenger RNA(m RNA)in immune cells,cytokines,and Kupffer cells,respectively.Results:A mouse model of ALF can be constructed successfully using LPS/D-Ga IN,which causes a cytokine storm in early disease progression.Innate immune cells change markedly with progression of liver failure.Earlier use of Dex,at 0 h rather than 1 h,could significantly improve the progression of ALF induced by LPS/D-Ga IN in mice.Numbers of innate immune cells,especially Kupffer cells and neutrophils,increased significantly in the Dex-treated group.In vivo experiments indicated that the therapeutic effect of Dex is exerted mainly via the glucocorticoid receptor(Gr).Sequencing of Kupffer cells revealed that Dex could increase m RNA transcription level of nuclear receptor subfamily 4 group A member 1(Nr4 a1),and that this effect disappeared after Gr inhibition.Conclusions:In LPS/D-Ga IN-induced ALF mice,early administration of Dex improved ALF by increasing the numbers of innate immune cells,especially Kupffer cells and neutrophils.Gr-dependent Nr4 a1 upregulation in Kupffer cells may be an important ALF effect regulated by Dex in this process.展开更多
文摘According to Psychological theories of motivation, sexuality is a biological need which urges to satisfy sexual desire. Though it is not essential for the survival of an individual, it plays a major role in the growth, development, adjustment and well-being. Therefore, sexuality is a common aspect in the existence and it should not be neglected. However, in many religious ethical issues, sexuality had been treated negatively and identified as a barrier for an advanced spiritual life. Even in tribal societies there were some sexual taboos that controlled man's sexual behavior to some extent. Among religious ethical codes, one may find that it had been placed an important position for controlling or completely eliminating sexual behaviors. In modem world, what is evident is that this so called sexual need has been used for many commercial and marketing purposes. Even in advertising field, sexual desire of man is used as a mean of attracting public. Phonograph has become a very profitable illegal professional today. Sexual medicines, drugs and tools are available everywhere in the society. Though sexual education had been included into the curriculum in schools and higher education institutions, the awareness of sexuality among people seems to be in a low level. While biologically man is compelled to fulfill sexual desire internally, it is motivated externally by many social factors. So that not only misconceptions of sexuality, but also misbehaviors of sexuality can be observed in the society today. By examining these current situations of man's sexual behaviors, there is a big need to formulate a sexual ethical code--a code of law with the help of religious teachings. Otherwise these various sexual behaviors may create more and more social and world problems. In this paper, my aim is to examine Buddhist ethics in order to formulate a sexual ethical code.
文摘Starting from the thesis that translation always takes place in a certain social and cultural context and is therefore conditioned by certain contextual factors, this paper examines the particular role that poetics played in Buddhist scripture translation that happened in ancient China. Buddhist poetics, in its associations with China's native poetics, did not work its way peacefully into the latter's embrace, to begin with. Instead, its appearance was first met with severe criticism and resistance. Aware of this problem, Buddhist translators in ancient China made continuous efforts in adapting Buddhist translations to the reading habits of the local people, which helped to ensure an easier acceptance of Buddhist philosophy by the Chinese people. With the growth and advancement of Buddhism in China, Buddhist poetics was no longer regarded as an enemy by its Chinese counterpart, and the style of Buddhist scripture translation was therefore able to stick closer to that of the original texts. The conclusion is that the poetics of one foreign literary system, when it comes to a new cultural environment, instead of remaining unaltered, usually goes through a complicated process of clashing and confl cfing with the native poetics before they two become reconciled and compatible with each other.
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LEZ20H260001)the National Natural Science Foundation of China(No.81700552)。
文摘Background and objective:Acute liver failure(ALF)is a type of disease with high mortality and rapid progression with no specific treatment methods currently available.Glucocorticoids exert beneficial clinical effects on therapy for ALF.However,the mechanism of this effect remains unclear and when to use glucocorticoids in patients with ALF is difficult to determine.The purpose of this study was to investigate the specific immunological mechanism of dexamethasone(Dex)on treatment of ALF induced by lipopolysaccharide(LPS)/D-galactosamine(D-Ga IN)in mice.Methods:Male C57 BL/6 mice were given LPS and D-Ga IN by intraperitoneal injection to establish an animal model of ALF.Dex was administrated to these mice and its therapeutic effect was observed.Hematoxylin and eosin(H&E)staining was used to determine liver pathology.Multicolor flow cytometry,cytometric bead array(CBA)method,and next-generation sequencing were performed to detect changes of messenger RNA(m RNA)in immune cells,cytokines,and Kupffer cells,respectively.Results:A mouse model of ALF can be constructed successfully using LPS/D-Ga IN,which causes a cytokine storm in early disease progression.Innate immune cells change markedly with progression of liver failure.Earlier use of Dex,at 0 h rather than 1 h,could significantly improve the progression of ALF induced by LPS/D-Ga IN in mice.Numbers of innate immune cells,especially Kupffer cells and neutrophils,increased significantly in the Dex-treated group.In vivo experiments indicated that the therapeutic effect of Dex is exerted mainly via the glucocorticoid receptor(Gr).Sequencing of Kupffer cells revealed that Dex could increase m RNA transcription level of nuclear receptor subfamily 4 group A member 1(Nr4 a1),and that this effect disappeared after Gr inhibition.Conclusions:In LPS/D-Ga IN-induced ALF mice,early administration of Dex improved ALF by increasing the numbers of innate immune cells,especially Kupffer cells and neutrophils.Gr-dependent Nr4 a1 upregulation in Kupffer cells may be an important ALF effect regulated by Dex in this process.