Objective： The aim of the study was to observe the effects of Iobaplatin and oxaliplatin on biological behavior of colorectal carcinoma cell line. Methods： The human colorectal carcinoma cell line LoVo and HR-8348 w...Objective： The aim of the study was to observe the effects of Iobaplatin and oxaliplatin on biological behavior of colorectal carcinoma cell line. Methods： The human colorectal carcinoma cell line LoVo and HR-8348 were used in the present study, and different concentrations of Iobaplatin and oxaliplatin served as inhibitors. The invasion and metastasis potential were evaluated with Transwell chamber, and cell inhibition ratio was measured with MTT assay. Results： Lobaplatin and oxaliplatin could significantly decrease the abilities of invasion and metastasis of LoVo and HR-8348 as compared with the control group （P 〈 0.01）, but no difference between Iobaplatin and oxaliplatin groups was observed （P 〉 0.05）. No difference was found in the cell inhibition ratio between the Iobaplatin and oxaliplatin groups （P 〉 0.05）. Lobaplatin could inhibit colorectal carcinoma cells that oxaliplatin couldn＇t do. Conclusion： Lobaplatin is a new antitumor platinum drug and can inhibit colorectal carcinoma cells. Moreover, Iobaplatin could also inhibit colorectal carcinoma cells which are resistant to oxaliplatin.展开更多
In this paper, the authors analyze the impact of the specific ownership structure of the banking sector in Czech and Slovakia on the performance and applied strategies of particular banks during times of crisis. Did t...In this paper, the authors analyze the impact of the specific ownership structure of the banking sector in Czech and Slovakia on the performance and applied strategies of particular banks during times of crisis. Did the multinational banks pursue a coherent regional strategy to cope with the risks resulting from the crisis, or did they focus on finding local solutions？ The aim of this paper is to find answers to these questions. A case study is going to be used as a basic research method. Two members （Slovak and Czech） of four multinational banking groups are examined in the crisis year 2009, whereby both a qualitative analysis of the annual reports regarding strategic business or risk management decisions and a comparative quantitative analysis of selected financial data and risk indicators are employed. The authors have found that Czech and Slovak banks generally tried to follow the main strategic directions given by their parent banks during the financial crisis. However, particular financial results and risk profiles of respective subsidiaries of multinational banks still differ because of market factors specific to the different countries in which the subsidiaries are located.展开更多
For the purpose of describing the deformation characteristics of rocks,the effect of volume changes on mechanical properties of rocks should be taken into account with relation to the development of constitutive model...For the purpose of describing the deformation characteristics of rocks,the effect of volume changes on mechanical properties of rocks should be taken into account with relation to the development of constitutive model.Firstly,rocks are divided into three parts,i.e.,voids,a damaged part and an undamaged part in the course of loading.The void ratio was applied to describing the changes of voids or pores during the deformation process.Then,using statistical damage theory,a constitutive model was developed for rocks to describe their strain softening and hardening on the basis of investigating the relationship between the net stress and apparent stress,in which the influence of volume changes on rock behavior was correctly taken into account,such as the initial phase of compaction and the latter stage of dilation.Thirdly,a method of determining model parameters was also presented.Finally,this model was used to compare the theoretical results with those observed from experiments under conventional triaxial loading conditions.展开更多
文摘Objective： The aim of the study was to observe the effects of Iobaplatin and oxaliplatin on biological behavior of colorectal carcinoma cell line. Methods： The human colorectal carcinoma cell line LoVo and HR-8348 were used in the present study, and different concentrations of Iobaplatin and oxaliplatin served as inhibitors. The invasion and metastasis potential were evaluated with Transwell chamber, and cell inhibition ratio was measured with MTT assay. Results： Lobaplatin and oxaliplatin could significantly decrease the abilities of invasion and metastasis of LoVo and HR-8348 as compared with the control group （P 〈 0.01）, but no difference between Iobaplatin and oxaliplatin groups was observed （P 〉 0.05）. No difference was found in the cell inhibition ratio between the Iobaplatin and oxaliplatin groups （P 〉 0.05）. Lobaplatin could inhibit colorectal carcinoma cells that oxaliplatin couldn＇t do. Conclusion： Lobaplatin is a new antitumor platinum drug and can inhibit colorectal carcinoma cells. Moreover, Iobaplatin could also inhibit colorectal carcinoma cells which are resistant to oxaliplatin.
文摘In this paper, the authors analyze the impact of the specific ownership structure of the banking sector in Czech and Slovakia on the performance and applied strategies of particular banks during times of crisis. Did the multinational banks pursue a coherent regional strategy to cope with the risks resulting from the crisis, or did they focus on finding local solutions？ The aim of this paper is to find answers to these questions. A case study is going to be used as a basic research method. Two members （Slovak and Czech） of four multinational banking groups are examined in the crisis year 2009, whereby both a qualitative analysis of the annual reports regarding strategic business or risk management decisions and a comparative quantitative analysis of selected financial data and risk indicators are employed. The authors have found that Czech and Slovak banks generally tried to follow the main strategic directions given by their parent banks during the financial crisis. However, particular financial results and risk profiles of respective subsidiaries of multinational banks still differ because of market factors specific to the different countries in which the subsidiaries are located.
基金Project(2006AA11Z104) supported by the National High-Tech Research and Development Program of China
文摘For the purpose of describing the deformation characteristics of rocks,the effect of volume changes on mechanical properties of rocks should be taken into account with relation to the development of constitutive model.Firstly,rocks are divided into three parts,i.e.,voids,a damaged part and an undamaged part in the course of loading.The void ratio was applied to describing the changes of voids or pores during the deformation process.Then,using statistical damage theory,a constitutive model was developed for rocks to describe their strain softening and hardening on the basis of investigating the relationship between the net stress and apparent stress,in which the influence of volume changes on rock behavior was correctly taken into account,such as the initial phase of compaction and the latter stage of dilation.Thirdly,a method of determining model parameters was also presented.Finally,this model was used to compare the theoretical results with those observed from experiments under conventional triaxial loading conditions.
