The retrospective study showed that 87.4%(248/279) ovarian poor responder could be reversed by reduced the dose of GnRH-a or increased initial Gn dose compared with full or a half dose and one third dose of GnRH-a dow...The retrospective study showed that 87.4%(248/279) ovarian poor responder could be reversed by reduced the dose of GnRH-a or increased initial Gn dose compared with full or a half dose and one third dose of GnRH-a down-regulation groups,only 11.1%(31/279) cases taken place ovarian poor responder again in next IVF-ET cycle.The result implied that profound ovarian suppression could be reversed by reduced GnRH-a dose or increased Gn dose in women with ovarian normal function.The dose of GnRH-a may have an impact on the steroidgenesis in IVF-ET cycles.展开更多
The aim of this study is to investigate the difference on the outcome of IVF-ET between the patients with and without endometriosis,and whether prolonged GnRH-a therapy improves outcome of IVF-ET in patients with endo...The aim of this study is to investigate the difference on the outcome of IVF-ET between the patients with and without endometriosis,and whether prolonged GnRH-a therapy improves outcome of IVF-ET in patients with endometriosis.The Results shows patients with endometriosis had significantly lower number of oocytes retrieved,but with similar implantation rate and clinical pregnancy rate in comparison to tubal factor infertility,and prolonged GnRH-a therapy for 2-6 months improves outcome of IVF-ET in patients with endometriosis.展开更多
Spontaneous pregnancy may be achieved in GnRH-a down-regulation.The main causes are that GnRH-a is given inadvertently during early pregnancy and the flare-up effect of GnRH-a administration induces ovulation.There ha...Spontaneous pregnancy may be achieved in GnRH-a down-regulation.The main causes are that GnRH-a is given inadvertently during early pregnancy and the flare-up effect of GnRH-a administration induces ovulation.There has been concern regarding the luteolytic effect of the agonist and teratogenicity.Most investigators think that these pregnancies produce normal offspring and needn’t be terminated.When a pregnancy is confirmed,luteal support should be continued untill the 12th gestational week.展开更多
The gonadotrophic hormones,FSH and LH play separating but complementary roles in the regulation of the folliculogenesis and steroidgenesis,leading to follicular recruitment and selection,resulting in growth and matura...The gonadotrophic hormones,FSH and LH play separating but complementary roles in the regulation of the folliculogenesis and steroidgenesis,leading to follicular recruitment and selection,resulting in growth and maturation in a spontaneous menstrual cycle and during ovulation induction.In assisted reproduction techniques,however,the relative importance of threshold of FSH and LH during the follicular phase is still subject to extensive debate,and questions surrounding the optimal amount of FSH and LH in stimulation protocols using down-regulation by GnRH-a combined with gonadotrophin protocol.From experimental and clinical evidence it seems unequivocal that the flay up stage of GnRH-a action is helpful for enhancing follicular recruitment and prolonging the window of FSH threshold value,but the down-regulation stage action is correlated with suppressed LH level resulting in individual defect in ovulation stimulated.Another document is long-acting GnRH-a preparation including the full or a half-dosage has more profound pituitary desensitization than one-third dosage of long-acting and potent or short-acting preparations,which the serum LH level <0.5 IU/L at different study points during the follicular phase.展开更多
文摘The retrospective study showed that 87.4%(248/279) ovarian poor responder could be reversed by reduced the dose of GnRH-a or increased initial Gn dose compared with full or a half dose and one third dose of GnRH-a down-regulation groups,only 11.1%(31/279) cases taken place ovarian poor responder again in next IVF-ET cycle.The result implied that profound ovarian suppression could be reversed by reduced GnRH-a dose or increased Gn dose in women with ovarian normal function.The dose of GnRH-a may have an impact on the steroidgenesis in IVF-ET cycles.
文摘The aim of this study is to investigate the difference on the outcome of IVF-ET between the patients with and without endometriosis,and whether prolonged GnRH-a therapy improves outcome of IVF-ET in patients with endometriosis.The Results shows patients with endometriosis had significantly lower number of oocytes retrieved,but with similar implantation rate and clinical pregnancy rate in comparison to tubal factor infertility,and prolonged GnRH-a therapy for 2-6 months improves outcome of IVF-ET in patients with endometriosis.
文摘Spontaneous pregnancy may be achieved in GnRH-a down-regulation.The main causes are that GnRH-a is given inadvertently during early pregnancy and the flare-up effect of GnRH-a administration induces ovulation.There has been concern regarding the luteolytic effect of the agonist and teratogenicity.Most investigators think that these pregnancies produce normal offspring and needn’t be terminated.When a pregnancy is confirmed,luteal support should be continued untill the 12th gestational week.
文摘The gonadotrophic hormones,FSH and LH play separating but complementary roles in the regulation of the folliculogenesis and steroidgenesis,leading to follicular recruitment and selection,resulting in growth and maturation in a spontaneous menstrual cycle and during ovulation induction.In assisted reproduction techniques,however,the relative importance of threshold of FSH and LH during the follicular phase is still subject to extensive debate,and questions surrounding the optimal amount of FSH and LH in stimulation protocols using down-regulation by GnRH-a combined with gonadotrophin protocol.From experimental and clinical evidence it seems unequivocal that the flay up stage of GnRH-a action is helpful for enhancing follicular recruitment and prolonging the window of FSH threshold value,but the down-regulation stage action is correlated with suppressed LH level resulting in individual defect in ovulation stimulated.Another document is long-acting GnRH-a preparation including the full or a half-dosage has more profound pituitary desensitization than one-third dosage of long-acting and potent or short-acting preparations,which the serum LH level <0.5 IU/L at different study points during the follicular phase.
