目的提出育龄期妇女发生肺血栓栓塞症的一个新的独立危险因素。方法对1例育龄期不孕女性应用促排卵针注射用尿促性素(Menotrophin for Injection)2个月后发生急性肺血栓栓塞症的病例进行分析讨论并阅读相关文献进行分析总结。结果该患...目的提出育龄期妇女发生肺血栓栓塞症的一个新的独立危险因素。方法对1例育龄期不孕女性应用促排卵针注射用尿促性素(Menotrophin for Injection)2个月后发生急性肺血栓栓塞症的病例进行分析讨论并阅读相关文献进行分析总结。结果该患者不存在肿瘤、下肢静脉血栓、免疫系统疾病、易栓症、妊娠、分娩、口服避孕药、骨折制动等育龄期妇女常见诱发肺栓塞的高危因素。结论促排卵针注射用尿促性素为育龄期妇女发生肺血栓栓塞症的高危因素因其改变机体内环境的激素水平,其辅料甘露醇及注射用绒促性素(HCG)可能起协同作用。展开更多
Objective To observe the effect of electroacupuncture （EA） on egg quality of polycystic ovarian syndrome （PCOS） patients, and to explore its mechanism. Methods Two hundred patients who received in vitro fertilizat...Objective To observe the effect of electroacupuncture （EA） on egg quality of polycystic ovarian syndrome （PCOS） patients, and to explore its mechanism. Methods Two hundred patients who received in vitro fertilization-embryo transfer （IVF-ET） were divided into an EA group （102 cases） and a control group （98 cases） according to random number table. All the patients in the two groups were given Diane-35 and gonadotropin-releasing hormone agonist （GnRH-α） for ovarian hyperstimulation. Besides, EA intervention was applied to Shenshu （肾俞 BL 23）, Qihai （气海 GV 6）, Zusanli （足三里ST 36）, Sanyinjiao （三阴交 SP 6）, Neiguan （内关 PC 6） and Zigong （子宫 EX-CA1）, etc. in the EA group. Then egg quality, final outcome of pregnancy and levels of tumor necrosis factor-α （TNF-α） were compared between the two groups. Results （1） EA intervention significantly improved high quality embryo rate of PCOS patients （P〈0.05）, and clinical pregnancy rate was increased by 8.36%; （2） EA intervention significantly reduced the TNF-α levels of follicular fluid （13.61±15.46 vs 34.09±93.53, P〈0.05）; （3） TNF-α levels of serum and follicular fluid in the pregnancy group were lower than those of non-pregnancy group [pregnancy group： （53.91±63.32） pg/mL, （14.93±25.37） pg/mL, nonpregnancy group： （76.82 ± 82.96） pg/mL, （25.04 ± 35.79） pg/mL], and the differences were significant （both P〈0.05）. Conclusion EA improves egg quality of PCOS patients and increases the clinical pregnancy rate of IVF-ET, the mechanism may be related to TNF-α levels.展开更多
文摘目的提出育龄期妇女发生肺血栓栓塞症的一个新的独立危险因素。方法对1例育龄期不孕女性应用促排卵针注射用尿促性素(Menotrophin for Injection)2个月后发生急性肺血栓栓塞症的病例进行分析讨论并阅读相关文献进行分析总结。结果该患者不存在肿瘤、下肢静脉血栓、免疫系统疾病、易栓症、妊娠、分娩、口服避孕药、骨折制动等育龄期妇女常见诱发肺栓塞的高危因素。结论促排卵针注射用尿促性素为育龄期妇女发生肺血栓栓塞症的高危因素因其改变机体内环境的激素水平,其辅料甘露醇及注射用绒促性素(HCG)可能起协同作用。
基金Supported by the National Natural Science Foundation of China:30973790
文摘Objective To observe the effect of electroacupuncture （EA） on egg quality of polycystic ovarian syndrome （PCOS） patients, and to explore its mechanism. Methods Two hundred patients who received in vitro fertilization-embryo transfer （IVF-ET） were divided into an EA group （102 cases） and a control group （98 cases） according to random number table. All the patients in the two groups were given Diane-35 and gonadotropin-releasing hormone agonist （GnRH-α） for ovarian hyperstimulation. Besides, EA intervention was applied to Shenshu （肾俞 BL 23）, Qihai （气海 GV 6）, Zusanli （足三里ST 36）, Sanyinjiao （三阴交 SP 6）, Neiguan （内关 PC 6） and Zigong （子宫 EX-CA1）, etc. in the EA group. Then egg quality, final outcome of pregnancy and levels of tumor necrosis factor-α （TNF-α） were compared between the two groups. Results （1） EA intervention significantly improved high quality embryo rate of PCOS patients （P〈0.05）, and clinical pregnancy rate was increased by 8.36%; （2） EA intervention significantly reduced the TNF-α levels of follicular fluid （13.61±15.46 vs 34.09±93.53, P〈0.05）; （3） TNF-α levels of serum and follicular fluid in the pregnancy group were lower than those of non-pregnancy group [pregnancy group： （53.91±63.32） pg/mL, （14.93±25.37） pg/mL, nonpregnancy group： （76.82 ± 82.96） pg/mL, （25.04 ± 35.79） pg/mL], and the differences were significant （both P〈0.05）. Conclusion EA improves egg quality of PCOS patients and increases the clinical pregnancy rate of IVF-ET, the mechanism may be related to TNF-α levels.
