目的比较经尿道保留尿道前壁前列腺剜除术（transurethral ventral preserving enucleation of the prostate,TUVPEP）与经尿道前列腺电切术（transurethral resection of the prostate,TURP）治疗良性前列腺增生患者的安全性、效果和...目的比较经尿道保留尿道前壁前列腺剜除术（transurethral ventral preserving enucleation of the prostate,TUVPEP）与经尿道前列腺电切术（transurethral resection of the prostate,TURP）治疗良性前列腺增生患者的安全性、效果和严重并发症。方法200例良性前列腺增生（benign prostatic hyperplasia,BPH）患者,按照前列腺体积大小分为两层,M层为中大前列腺（45-80 g）,L层为巨大前列腺（〉80 g）,每层按随机数字表分为2组。M1组和L1组为试验组,M2组和L2组为对照组。试验组采用作者专利器械＂张氏多功能前列腺手术镜＂进行TUVPEP,简称张氏前列腺剜除术（Zhang’s enucleation of the prostate,ZSEP）,对照组进行TURP,统计手术持续时间、术中出血量、术后住院时间。出院后6个月随访,比较两组国际前列腺症状评分（IPSS）、生活质量评分（QOL）、最大尿流率（Q_（max））及严重并发症。采用SPSS 18.0统计软件进行分析,其中连续变量采用x±s表示,两组间比较采用t检验。结果 179例得到随访,试验组出血量显著少于对照组[M1组（27.63±20.35）m L与M2组（31.82±17.35）m L,P〈0.05;L1组（58.35±49.79）m L与L2组（73.39±43.78）m L,P〈0.05]。试验组住院时间显著缩短[M1组（3.80±1.03）d与M2组（6.61±1.91）d,P〈0.01;L1组（4.06±1.29）d与L2组（5.94±1.84）d,P〈0.01]。试验组术后Q_（max）显著高于对照组[M1组（21.10±7.56）m L/s与M2组（16.10±5.94）m L/s,P〈0.01;L1组（25.70±9.18）m L/s与L2组（16.20±5.01）m L/s,P〈0.01];试验组与对照组严重并发症分别为10%与21%,再次手术率分别为0%与6%,差异有统计学意义（P〈0.05）。结论与TURP比较,ZSEP显著减少出血量和手术时间,提高尿流率和减少严重并发症的发生,再次手术率极低,可缩短留置导尿时间和住院时间。展开更多
PURPOSE: Total mesorectal excision is the gold standard in the performance of an abdominoperineal resection but little has changed in the way the perineal operation is performed. A frequent problem is anterior dissect...PURPOSE: Total mesorectal excision is the gold standard in the performance of an abdominoperineal resection but little has changed in the way the perineal operation is performed. A frequent problem is anterior dissection. The aim of this study was to present the results of abdominoperineal resection using selected partial anterior en bloc resection to reduce recurrence. METHODS: The data were population-based and prospectively registered. Two experienced surgeons performed the operations. In selected cases, depending on clinical and magnetic resonance imaging findings, parts of the vagina or prostate close to the tumor were resected. All specimens were examined according to Quirke. RESULTS: Sixty-three patients underwent abdominoperineal resection with total mesorectal excision; 56 received preoperative radiotherapy. The tumors involved the anterior bowel wall in 40 cases and in 23 (58 percent) of them, en bloc resections were performed. The distance from the tumor to the conventional resection margin (without en bloc resection) was 0 mm in ten cases. The median follow-up period was 37 months. So far, one (1.7 percent) local recurrence has been detected in 58 (92 percent) curative and indeterminate cases. The cancer-specific five-year survival in these cases was 87 percent (Kaplan-Meier). CONCLUSION: A multimodal management regimen in patients with low rectal cancer, including preoperative radiotherapy and abdominoperineal resection with a high frequency of partial en bloc resection of the vagina or prostate, resulted in excellent local control and survival. In some male patients, excenteration with urinary stoma can be avoided.展开更多
文摘目的比较经尿道保留尿道前壁前列腺剜除术（transurethral ventral preserving enucleation of the prostate,TUVPEP）与经尿道前列腺电切术（transurethral resection of the prostate,TURP）治疗良性前列腺增生患者的安全性、效果和严重并发症。方法200例良性前列腺增生（benign prostatic hyperplasia,BPH）患者,按照前列腺体积大小分为两层,M层为中大前列腺（45-80 g）,L层为巨大前列腺（〉80 g）,每层按随机数字表分为2组。M1组和L1组为试验组,M2组和L2组为对照组。试验组采用作者专利器械＂张氏多功能前列腺手术镜＂进行TUVPEP,简称张氏前列腺剜除术（Zhang’s enucleation of the prostate,ZSEP）,对照组进行TURP,统计手术持续时间、术中出血量、术后住院时间。出院后6个月随访,比较两组国际前列腺症状评分（IPSS）、生活质量评分（QOL）、最大尿流率（Q_（max））及严重并发症。采用SPSS 18.0统计软件进行分析,其中连续变量采用x±s表示,两组间比较采用t检验。结果 179例得到随访,试验组出血量显著少于对照组[M1组（27.63±20.35）m L与M2组（31.82±17.35）m L,P〈0.05;L1组（58.35±49.79）m L与L2组（73.39±43.78）m L,P〈0.05]。试验组住院时间显著缩短[M1组（3.80±1.03）d与M2组（6.61±1.91）d,P〈0.01;L1组（4.06±1.29）d与L2组（5.94±1.84）d,P〈0.01]。试验组术后Q_（max）显著高于对照组[M1组（21.10±7.56）m L/s与M2组（16.10±5.94）m L/s,P〈0.01;L1组（25.70±9.18）m L/s与L2组（16.20±5.01）m L/s,P〈0.01];试验组与对照组严重并发症分别为10%与21%,再次手术率分别为0%与6%,差异有统计学意义（P〈0.05）。结论与TURP比较,ZSEP显著减少出血量和手术时间,提高尿流率和减少严重并发症的发生,再次手术率极低,可缩短留置导尿时间和住院时间。
文摘PURPOSE: Total mesorectal excision is the gold standard in the performance of an abdominoperineal resection but little has changed in the way the perineal operation is performed. A frequent problem is anterior dissection. The aim of this study was to present the results of abdominoperineal resection using selected partial anterior en bloc resection to reduce recurrence. METHODS: The data were population-based and prospectively registered. Two experienced surgeons performed the operations. In selected cases, depending on clinical and magnetic resonance imaging findings, parts of the vagina or prostate close to the tumor were resected. All specimens were examined according to Quirke. RESULTS: Sixty-three patients underwent abdominoperineal resection with total mesorectal excision; 56 received preoperative radiotherapy. The tumors involved the anterior bowel wall in 40 cases and in 23 (58 percent) of them, en bloc resections were performed. The distance from the tumor to the conventional resection margin (without en bloc resection) was 0 mm in ten cases. The median follow-up period was 37 months. So far, one (1.7 percent) local recurrence has been detected in 58 (92 percent) curative and indeterminate cases. The cancer-specific five-year survival in these cases was 87 percent (Kaplan-Meier). CONCLUSION: A multimodal management regimen in patients with low rectal cancer, including preoperative radiotherapy and abdominoperineal resection with a high frequency of partial en bloc resection of the vagina or prostate, resulted in excellent local control and survival. In some male patients, excenteration with urinary stoma can be avoided.
