AIM: α-Lipoic acid (ALA) has been used as an antioxidant.The aim of this study was to investigate the effect of α-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats.METHODS: ALA at 1...AIM: α-Lipoic acid (ALA) has been used as an antioxidant.The aim of this study was to investigate the effect of α-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats.METHODS: ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 μg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase,amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis.RESULTS: ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However,the secretion of IL-1β, IL-6, and TNF-α were comparable in CCK octapeptide-induced acute pancreatitis.CONCLUSION: ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.展开更多
The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in...The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in the Cloud.In this paper,we present an alternative approach which divides big data into sequenced parts and stores them among multiple Cloud storage service providers.Instead of protecting the big data itself,the proposed scheme protects the mapping of the various data elements to each provider using a trapdoor function.Analysis,comparison and simulation prove that the proposed scheme is efficient and secure for the big data of Cloud tenants.展开更多
Neonicotinoids including IM (Imidacloprid) are widely used as plant systemic insecticides. Several studies have indicated that pesticide toxicity may be associated with the enhanced production of ROS (reactive oxyg...Neonicotinoids including IM (Imidacloprid) are widely used as plant systemic insecticides. Several studies have indicated that pesticide toxicity may be associated with the enhanced production of ROS (reactive oxygen species). Both β-carotene (I3C) and hesperidin (H) have an antioxidant property and quench free radicals. This study aimed to clarify the protective role of β-carotene and hesperidin as natural antioxidants on IM induced toxicity in hematological parameters and markers of cardiac muscle activity in male albino rats. The treatment of rats with IM showed a significant decrease in hemoglobin (Hb %), MCH (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin concentration), HCT (hematocrit) values and RBCs count comparing with control group. On the other hand, MCV (mean corpuscular volume), WBCs (white blood cells) and Pits (platelets) count pronounced a significant increase in IM group comparing to control. Also, αFP (plasma alpha fetoprotein), CEA (carcinoembryonic antigen), CK (creatine kinase), CK-MB (creatine phosphokinase myocardial band) and LDH (lactate dehydrogenase) clarify a significant increase in IM group comparing to control. Both β-carotene and hesperidin mitigate the deleterious effects of IM on previous parameters. β-Carotene and hesperidin may protect hematopoietic system and heart muscle against toxicity of IM. These improvements of the results clarify the protective effect of the used antioxidants. Conclusion: β-carotene and hesperidin, natural antioxidants, have a protective effect against IM evoked hematological and biochemical changes.展开更多
Light is a fundamental source of energy but is also potentially harmful to organisms. Plants have evolved a variety of regulatory mechanisms to respond to the naturally varying light conditions. Xanthophyll cycle is n...Light is a fundamental source of energy but is also potentially harmful to organisms. Plants have evolved a variety of regulatory mechanisms to respond to the naturally varying light conditions. Xanthophyll cycle is now recognized as a key regulator and photoprotective mechanism found ubiquitously in plants. Xanthophyll cycle has multiple functions, such as thermal dissipation, protection against oxidative stress caused by light, modulation of the structure of thylakoid membrane, involving in blue light signal transduction and regulating the synthesis ofABA (Abscisic acid). VDE (Violaxanth de-epoxidase) and ZE (zeaxanth epoxidase), are involved in xanthophyll cycle. This paper outlined the functions of xanthophylls cycle and its relative enzymes.展开更多
Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal bra...Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal brain lesions due to the complexity of neonatal hypoxic-ischemic pathophysiology, the search of new neuroprotective therapies is of great interest. In this regard, therapeutic possibilities of the endocannabinoid system have grown lately. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. Concerning perinatal asphyxia, the neuroprotective role of this endogenous system is emerging these years. The present review mainly focused on the current knowledge of the cannabinoids as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.展开更多
基金Supported by the Next Generation Growth Engine Program grant from the Ministry of Science and Technology (2004-00075), South Korea
文摘AIM: α-Lipoic acid (ALA) has been used as an antioxidant.The aim of this study was to investigate the effect of α-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats.METHODS: ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 μg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase,amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis.RESULTS: ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However,the secretion of IL-1β, IL-6, and TNF-α were comparable in CCK octapeptide-induced acute pancreatitis.CONCLUSION: ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.
基金supported in part by the National Nature Science Foundation of China under Grant No.61402413 and 61340058 the "Six Kinds Peak Talents Plan" project of Jiangsu Province under Grant No.ll-JY-009+2 种基金the Nature Science Foundation of Zhejiang Province under Grant No.LY14F020019, Z14F020006 and Y1101183the China Postdoctoral Science Foundation funded project under Grant No.2012M511732Jiangsu Province Postdoctoral Science Foundation funded project Grant No.1102014C
文摘The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in the Cloud.In this paper,we present an alternative approach which divides big data into sequenced parts and stores them among multiple Cloud storage service providers.Instead of protecting the big data itself,the proposed scheme protects the mapping of the various data elements to each provider using a trapdoor function.Analysis,comparison and simulation prove that the proposed scheme is efficient and secure for the big data of Cloud tenants.
文摘Neonicotinoids including IM (Imidacloprid) are widely used as plant systemic insecticides. Several studies have indicated that pesticide toxicity may be associated with the enhanced production of ROS (reactive oxygen species). Both β-carotene (I3C) and hesperidin (H) have an antioxidant property and quench free radicals. This study aimed to clarify the protective role of β-carotene and hesperidin as natural antioxidants on IM induced toxicity in hematological parameters and markers of cardiac muscle activity in male albino rats. The treatment of rats with IM showed a significant decrease in hemoglobin (Hb %), MCH (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin concentration), HCT (hematocrit) values and RBCs count comparing with control group. On the other hand, MCV (mean corpuscular volume), WBCs (white blood cells) and Pits (platelets) count pronounced a significant increase in IM group comparing to control. Also, αFP (plasma alpha fetoprotein), CEA (carcinoembryonic antigen), CK (creatine kinase), CK-MB (creatine phosphokinase myocardial band) and LDH (lactate dehydrogenase) clarify a significant increase in IM group comparing to control. Both β-carotene and hesperidin mitigate the deleterious effects of IM on previous parameters. β-Carotene and hesperidin may protect hematopoietic system and heart muscle against toxicity of IM. These improvements of the results clarify the protective effect of the used antioxidants. Conclusion: β-carotene and hesperidin, natural antioxidants, have a protective effect against IM evoked hematological and biochemical changes.
文摘Light is a fundamental source of energy but is also potentially harmful to organisms. Plants have evolved a variety of regulatory mechanisms to respond to the naturally varying light conditions. Xanthophyll cycle is now recognized as a key regulator and photoprotective mechanism found ubiquitously in plants. Xanthophyll cycle has multiple functions, such as thermal dissipation, protection against oxidative stress caused by light, modulation of the structure of thylakoid membrane, involving in blue light signal transduction and regulating the synthesis ofABA (Abscisic acid). VDE (Violaxanth de-epoxidase) and ZE (zeaxanth epoxidase), are involved in xanthophyll cycle. This paper outlined the functions of xanthophylls cycle and its relative enzymes.
基金supported by grants from Fondo de Investigación Sanitaria of Spanish Ministry of Health(PS09/02326)the Basque Government(GCI-07/79,IT-287-07)
文摘Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal brain lesions due to the complexity of neonatal hypoxic-ischemic pathophysiology, the search of new neuroprotective therapies is of great interest. In this regard, therapeutic possibilities of the endocannabinoid system have grown lately. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. Concerning perinatal asphyxia, the neuroprotective role of this endogenous system is emerging these years. The present review mainly focused on the current knowledge of the cannabinoids as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.