Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In t...Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.展开更多
Objective： To investigate the neurobiological mechanism of electroacupuncture in inhibiting bladder hyperactivity induced by L-dopa by observing frequency of urination and expression of vasoactive intestinal peptide ...Objective： To investigate the neurobiological mechanism of electroacupuncture in inhibiting bladder hyperactivity induced by L-dopa by observing frequency of urination and expression of vasoactive intestinal peptide （VIP） in sacral dorsal horn. Methods： Forty-eight rats were allocated with a random number table into normal group （n=6）, control group （n=14）, model group （n=14）, and electroacupuncture group （n=14）. All rats were treated with bladder encheiresis. Rats in the normal group were not given injection. Rats in the control group were intraperitoneally injected with physiological saline. Rats in the model and electroacupuncture groups were intraperitoneally injected with Carbidopa and L-dopa. Continuous cystometry was performed to observe the effect of electroacupuncture on urination frequency. Dynamic changes of VIP in the sacral dorsal horn were measured by immunohistochemistry and quantitative image analysis after electroacupuncture. Results： In rats of model group, urination frequency increased after treatment （P〈0.05）, in rats of electroacupuncture group, it increased at 15-75 min after L-dopa injection than that before treatment （P〈0.05）, and was same as that before treatment at 75-105 min after L-dopa injection. Positive fiber and end of VIP in the sacral dorsal horn of rats in the electroacupuncture group were more than those in the normal and model groups at 3 h after L-dopa injection （P〈0.05）, and was more than those in the normal group at 8 h after L-dopa injection （P〈0.05）, and there was no significant difference between electro-acupuncture and normal groups. Conclusion： Electroacuptmcture can promote the release of VIP from afferent nerves in rats with L-dopa-induced bladder hyperactivity to decrease urination frequency.展开更多
基金Supported by the subject of clinical research on treating chronic fatigue syndrome by acupuncture on the reaction point of back-shu points in Dongzhimen Hospital Beijing University of Chinese Medicine:2016-DZM111-JC006~~
文摘Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.
文摘Objective： To investigate the neurobiological mechanism of electroacupuncture in inhibiting bladder hyperactivity induced by L-dopa by observing frequency of urination and expression of vasoactive intestinal peptide （VIP） in sacral dorsal horn. Methods： Forty-eight rats were allocated with a random number table into normal group （n=6）, control group （n=14）, model group （n=14）, and electroacupuncture group （n=14）. All rats were treated with bladder encheiresis. Rats in the normal group were not given injection. Rats in the control group were intraperitoneally injected with physiological saline. Rats in the model and electroacupuncture groups were intraperitoneally injected with Carbidopa and L-dopa. Continuous cystometry was performed to observe the effect of electroacupuncture on urination frequency. Dynamic changes of VIP in the sacral dorsal horn were measured by immunohistochemistry and quantitative image analysis after electroacupuncture. Results： In rats of model group, urination frequency increased after treatment （P〈0.05）, in rats of electroacupuncture group, it increased at 15-75 min after L-dopa injection than that before treatment （P〈0.05）, and was same as that before treatment at 75-105 min after L-dopa injection. Positive fiber and end of VIP in the sacral dorsal horn of rats in the electroacupuncture group were more than those in the normal and model groups at 3 h after L-dopa injection （P〈0.05）, and was more than those in the normal group at 8 h after L-dopa injection （P〈0.05）, and there was no significant difference between electro-acupuncture and normal groups. Conclusion： Electroacuptmcture can promote the release of VIP from afferent nerves in rats with L-dopa-induced bladder hyperactivity to decrease urination frequency.
