The innate immune response provides the initial defense against infection. This is accomplished by families of pattern recognition receptors (PRRs) that bind to conserved molecules in bacteria, fungi and viruses. PRRs...The innate immune response provides the initial defense against infection. This is accomplished by families of pattern recognition receptors (PRRs) that bind to conserved molecules in bacteria, fungi and viruses. PRRs are finely regulated by elaborate mechanisms to ensure a beneficial outcome in response to foreign invaders. MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that are emerging as important regulators in immune responses at the post-transcriptional level, through the inhibition of translation, or by inducing mRNA degradation. It has been shown that miRNAs have unique expression profiles in cells of the innate immune systems and play pivotal roles in regulating the signal pathways of innate receptors, including Toll-like receptors, RIG-I-like receptors and Nod-like receptors. We have summarized the recent literature providing new insights into the regulation of innate receptor pathways by miRNAs.展开更多
文摘目的:了解银屑病治疗靶向药物的研究进展,为其新药研发提供参考。方法:以"银屑病""生物""靶向治疗""Psoriasis""Biological""Targeted therapy"等为关键词,组合查询2000年-2018年10月在中国期刊全文数据库、万方、维普、PubMed、Spring-erLink、Web of Science、Elsevier等数据库中的相关文献,对银屑病治疗药物的作用靶点及其制剂的研究进展进行归纳和总结。结果与结论:共检索到相关文献1 913篇,其中有效文献48篇。目前,银屑病治疗靶向药物主要是肿瘤坏死因子α抑制剂、白细胞介素及其受体抑制剂、磷酸二酯酶4抑制剂、T细胞靶向治疗药、细胞信号传导小分子抑制剂、血管内皮生长因子抑制剂等。此外,随着银屑病作用机制的深入研究,也发现了很多新的作用靶点,如神经生长因子抑制剂、趋化因子受体拮抗剂、丝裂原激活的蛋白激酶抑制剂、转录激活因子抑制剂等可作用于新的靶点,均可能在银屑病中发挥治疗作用,这些靶点为进一步研究的方向和具体研究点等提供新思路。
文摘The innate immune response provides the initial defense against infection. This is accomplished by families of pattern recognition receptors (PRRs) that bind to conserved molecules in bacteria, fungi and viruses. PRRs are finely regulated by elaborate mechanisms to ensure a beneficial outcome in response to foreign invaders. MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that are emerging as important regulators in immune responses at the post-transcriptional level, through the inhibition of translation, or by inducing mRNA degradation. It has been shown that miRNAs have unique expression profiles in cells of the innate immune systems and play pivotal roles in regulating the signal pathways of innate receptors, including Toll-like receptors, RIG-I-like receptors and Nod-like receptors. We have summarized the recent literature providing new insights into the regulation of innate receptor pathways by miRNAs.
