激光干涉任意转角测量信号的获得及误差补偿技术

采用信号处理的方法对激光干涉测角系统的特性进行线性化处理,需要产生两路正交信号。采用空间互相垂直的两套干涉系统获得信号难免会使系统复杂、调整困难,因此提出了一种插值处理方法,可以利用测量得到的一路信号获得线性输出信号。输出信号的非线性误差较处理前大大减小了,但是无法满足高精度测量的要求。还提出了针对误差产生的原因进行的误差补偿技术。实验结果表明,提出的方法可以实现任意转角的高精度测量,光程差的测量误差小于±0 2μm,对应的转角测量误差为0 63″。

融合注意力机制的CS-BiLSTM深度回声消除算法

在全双工通信系统中,声学回声会降低用户的体验,针对在双向通话场景下自适应滤波算法消除声学回声效果不理想以及非线性声学回声难以消除的问题,提出一种注意力机制与BiLSTM网络相结合的CS-BiLSTM深度声学回声消除算法。首先通过构建BiLSTM网络提取语音的时序特征,之后引入通道和空间注意力机制提取回声信号的空间特征信息,并融合均方根误差与平均绝对误差提出一种新的损失函数,提高模型的鲁棒性。改进后的CS-BiLSTM网络模型能够获得清晰的语音信号,具有更好的回声消除性能。仿真结果表明,在非线性回声和双向通话环境下,与其他几种参考算法相比,所提出的CS-BiLSTM算法在感知语音质量评价方面明显优于其他算法,更有效地实现了回声消除,此外,该算法结构简单且模型参数量更少。

功能获得性信号转导和转录活化子1基因缺陷

慢性皮肤黏膜念珠菌病（CMC）特征为持续或反复指甲、皮肤、口腔或生殖道黏膜白色念珠菌感染，可由各种免疫内在缺陷引起。CMC可见于T淋巴细胞免疫缺陷病、高IgE综合征、白细胞介素（IL）－12p40和IL－12受体β1（IL－12Rβ1）缺陷、Caspase募集结构域9缺陷和自身免疫性多内分泌病念珠菌病外胚层发育不良。CMC的发病机制提示IL－17A、IL－17F、IL－22免疫受损。常染色体隐性遗传IL－17RA缺陷，显性负调节的IL－17F突变是孤立的CMC（CMCD）的病因。近一半的CMCD患者由功能获得性信号转导和转录活化子1突变所致。患者还有细菌感染、病毒感染、自身免疫和炎症疾病等，提示具有广阔的临床异质性。

Enhancing manual P-phase arrival detection and automatic onset time picking in a noisy microseismic data in underground mines

Accurate detection and picking of the P-phase onset time in noisy microseismic data from underground mines remains a big challenge. Reliable P-phase onset time picking is necessary for accurate source location needed for planning and rescue operations in the event of failures. In this paper, a new technique based on the discrete stationary wavelet transform （DSWT）and higher order statist!cs, is proposed for processing noisy data from underground mines. The objectives of this method are to （1） Improve manual detection and tPicking of P-phase onset; and （ii） provide an automatic means of detecting and picking P-phase onset me accurately. The DSWT is first used to filter the signal over several scales. The manual P-phase onset detection and picking are then obtained by computing the signal energy across selected scales with frequency bands that capture the signal of interest. The automatic P-phase onset, on the other hand, is achieved by using skewness- and kurtosis-based criterion applied to selected scales in a time-frequency domain. The method was tested using synthetic and field data from an underground limestone mine. Results were compared with results obtained by using the short-term to long-term average （STA/LTA） ratio and that by Reference Ge et al. （2009）. The results show that the me!hod provides a more reliable estimate of the P-phase onset arrival than the STA]LTA method when the signal to noise ratio is very low. Also, the results obtained from the field data matched accurately with the results from Reference Ge et al. （2009）.

基于磁性纳米颗粒和金纳米粒子构建DNA电化学生物传感技术

本文构建了一种基于纳米粒子、茎环DNA和丝网印刷电极(SPCE)的电化学生物传感技术用于乳腺癌基因的快速、灵敏检测。该传感技术中,探针DNA的两端分别标记了巯基和生物素,巯基用于与金纳米粒子(AuNPs)作用,生物素用于与磁性纳米颗粒(MNPs)表面修饰的链酶亲和素作用以达到富集的目的,之后利用SPCE进行电化学检测。无目标DNA存在时,双标记DNA保持茎环结构,使得生物素分子很难和MNPs上的亲和素接触。一旦加入目标DNA,茎环结构打开,生物素得以与MNPs上的链霉亲和素发生特异性结合,形成的复合物(MNPs-DNA-AuNPs)通过磁性富集到SPCE表面,从而获得AuNPs的电化学信号。该DNA电化学生物传感对单碱基错配有良好的分辨能力,完全互补DNA的检出限为8.0×10-13 mol/L。