In recent years,Wnt/β-catenin signaling has been identified as a key player in embryogenesis and human diseases.Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt,β-catenin,Axin...In recent years,Wnt/β-catenin signaling has been identified as a key player in embryogenesis and human diseases.Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt,β-catenin,Axin,APC,GSK-3β and CK1,which interact and coordinate to regulate the expressions of cell signaling molecules.The latest evidences suggest that some components of the Wnt/β-catenin signaling,like APC,GSK-3β,CK1,Dkk2 and WISE,play dual roles different from what they have been thought previously.Here we reviewed some recent discoveries on the canonical Wnt/β-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.展开更多
文摘In recent years,Wnt/β-catenin signaling has been identified as a key player in embryogenesis and human diseases.Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt,β-catenin,Axin,APC,GSK-3β and CK1,which interact and coordinate to regulate the expressions of cell signaling molecules.The latest evidences suggest that some components of the Wnt/β-catenin signaling,like APC,GSK-3β,CK1,Dkk2 and WISE,play dual roles different from what they have been thought previously.Here we reviewed some recent discoveries on the canonical Wnt/β-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.
文摘近年来肥胖发病率逐渐上升,流行病学研究发现,肥胖对心房颤动(atrial fibrillation,AF)的发生和预后有重要影响[1-2]。肥胖相关AF的机制尚不明确,但二者都与炎性反应增强有关。最近,肥胖诱导AF与核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎性小体之间建立了联系,成为研究热点[3]。NLRP3炎性小体参与肥胖相关AF可能的机制涉及炎症、纤维化结构重构和离子通道相关电重构。
