创建信息中药学及其意义

中医基础理论现代化是中药现代化开发研究的基本前提。信息中医学提出以血液指纹图谱建立藏象信息模型体系,实现信息化处理海量生命信息的方法。以此为基础创建信息中药学,创造了适合中医药研究的生理病理模型,实现了中医学对实验动物属性的划分,创新中药药理学研究方法,实现中药基础理论研究客观化。对中药学进行了的重新分类,扩展了传统中药学的范围,更解决和发展了中药应用理论,有利于指导临床用药及开发新产品。

Digital Chinese Medicine Research: an Overview

Digital Chinese medicine(DCM)is an emerging interdisciplinary field developed from traditional Chinese medicine(TCM)and information science.In this article,we consider the significance and propose an architecture for DCM research,and highlight the key tasks that need to be performed to provide references for the integration of information science into Chinese medicine research.

Similarities between "Big Data" and Traditional Chinese Medicine information

In this paper,we analyze the four distinct characteristics of information on Traditional Chinese Medicine(TCM), namely epistemological information,phenomenon information, overall information, and time information. These characteristics bear to some extent strong similarity to the three characteristics of "Big Data", namely integrity data, fuzzy data and correlation data, so the advent of the age of "Big Data" is bound to create good opportunities for the development of TCM informatics and is also be expected to provide methods and techniques for processing and analysis of TCM "comprehensive data".

Integrating bioinformatics to identify and analyze feature genes of acute myocardial infarction and potential Chinese medicine prediction

In the present study,the Gene Expression Omnibus(GEO)dataset combined with machine learning was used to study differential genes in acute myocardial infarction(AMI)and to predict potential components and herbal medicines with regulatory effects.The human genome datasets of AMI(GSE66360 and GSE61145)were downloaded from the GEO database,and GSE66360 was used as the test set.After correction by normalization Between Arrays package of R,the limma package was used to obtain differentially expressed genes(DEGs).Then,we carried out Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG),and Disease Ontology(DO)enrichment analysis of DEGs.The feature genes were screened by SVM and random forest tree method,and the obtained feature genes were verified by the GSE61145 dataset.The components of traditional Chinese medicine(TCM)corresponding to AMI feature genes were found by the CTD database,and the corresponding TCM components were mapped by the Coremine database.According to the Dictionary of Traditional Chinese Medicine,Chinese Materia Medica,and Chinese Pharmacopoeia,the frequency,the four qi,five flavors,and meridian tropism of the obtained TCM were summarized.Through the analysis of the GSE66360 dataset,317 DEGs were obtained,of which 306 were up-regulated,and 11 were down-regulated.GO and KEGG enrichment analyses showed that the DEGs of AMI were mainly involved in neutrophil-mediated inflammation and immune response,abnormal lipid metabolism,lipid,and atherosclerosis-related pathways.DO enrichment analysis showed that the DEGs were closely related to atherosclerotic cardiovascular diseases and lung diseases.Six feature genes were obtained by SVM and random forest tree method,including ZFP36,GADD45A,PELI1,METRNL,MMP9,and CXCL16.Moreover,we found that the treatment of AMI Chinese medicine to sweet,bitter,and warm mostly attributed to the spleen,stomach,and liver.Besides,the components corresponding to the feature genes regulating AMI(ZFP36,GADD45A,PELI1,METRNL,MMP9,CXCL16)mainly included benzo(a)pyrene,tetrachlorodibenzodioxin,acetaminophen,and so on,and the corresponding TCMs included Camellia sinensis,Curcumaaromatica Salisb,Panax ginseng,and so on.In addition,a sweet taste,bitter taste,warm taste,and channel entry mainly belonged to the spleen,stomach,and liver meridians.

Analysis of clinical application patterns in acupuncture-moxibustion treatment of Alzheimer disease

Objective:To summarize the clinical application patterns in acupuncture-moxibustion treatment of AD by reviewing the clinical literatures on acupuncture-moxibustion for Alzheimer disease(AD)published between January 2009 and December 2019.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),Chinese Medicine Acupuncture-moxibustion Information Database,PubMed Medical Data Retrieval Service System,Springer Database and Ovid Technologies(OVID)were retrieved to screen clinical studies of acupuncture-moxibustion treatment of AD according to the inclusion and exclusion criteria to conduct quantitative,clustering and association analyses.Results:In acupuncture-moxibustion treatment of AD,the frequently used points were Baihui(GV 20),Zusanli(ST 36),Sishencong(EX-HN 1),Taixi(KI 3),Sanyinjiao(SP 6),and Neiguan(PC 6)in the descending order.Regarding meridians,the most frequently used one was the Governor Vessel,followed by the Stomach Meridian of Foot Yangming and Gallbladder Meridian of Foot Shaoyang.From the perspective of body regions,the points in the head-face region and the lower-limb region had the highest frequencies,followed by the upper-limb,back and chest-abdomen regions.The point group,Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Sanyinjiao(SP 6),showed the most significant association,and the group winning the second place was Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Zusanli(ST 36).The clustering analysis showed that the commonly used point pairs included Zusanli(ST 36)-Sishencong(EX-HN 1)and Taixi(KI 3)-Sanyinjiao(SP 6),which were closely associated with Baihui(GV 20).By analyzing the three commonly used acupuncture-moxibustion methods,acupuncture plus medication was found achieving the best result in the total effective rate and mini-mental state examination(MMSE)score,followed by monotherapy of electroacupuncture therapy,and these two methods were superior to acupuncture alone(P<0.05);the scores of MMSE,Alzheimer disease assessment scale-cognitive section(ADAS-cog)and activity of daily living scale(ADL)showed significant improvements after treatment(all P<0.01).Conclusion:In the acupuncture-moxibustion prescriptions for AD,the main points are Baihui(GV 20),Sishencong(EX-HN 1),Neiguan(PC 6),Zusanli(ST 36),Sanyinjiao(SP 6)and Taixi(KI 3).Monotherapy of acupuncture has the highest frequency amongst the treatment methods,but its effective rate is lower than that of acupuncture plus medication and monotherapy of electroacupuncture.