In this paper, we present the decoupling bang-bang （BB） twin-born pulses to suppress the genera/deco- herence, both amplitude and phase decoherence, in a three-level atom in V- and Ξ-configurations. We give the exa...In this paper, we present the decoupling bang-bang （BB） twin-born pulses to suppress the genera/deco- herence, both amplitude and phase decoherence, in a three-level atom in V- and Ξ-configurations. We give the exact sequence of periodic twinborn pulses in such systems.展开更多
AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients ...AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors(PPIs) for at least 8 wk,and the therapeutic outcome was assessed through validated questionnaires(GERD impact scale,GIS;visual analogue scale,VAS).LPR diagnosis was performed by ear,nose and throat specialists using the reflux finding score(RFS) and reflux symptom index(RSI).After a 16-d wash-out from PPIs,all patients underwent an upper endoscopy,stationary esophageal manometry,24-h multichannel intraluminal impedance and pH(MII-pH) esophageal monitoring.A positive correlation between LPR diagnosis and GERD was supposed based on the presence of esophagitis(ERD),pathological acid exposure time(AET) in the absence of esophageal erosions(NERD),and a positive correlation between symptoms and refluxes(hypersensitive esophagus,HE).RESULTS:The male/female ratio was 0.52(14/27),the mean age ± SD was 51.5 ± 12.7 years,and the mean body mass index was 25.7 ± 3.4 kg/m 2.All subjects reported one or more LPS.Twenty-five out of 41 patients also had typical GERD symptoms(heartburn and/or regurgitation).The most frequent laryngoscopic findings were posterior laryngeal hyperemia(38/41),linear indentation in the medial edge of the vocal fold(31/41),vocal fold nodules(6/41) and diffuse infraglottic oedema(25/41).The GIS analysis showed that 10/41 patients reported symptom relief with PPI therapy(P < 0.05);conversely,23/41 did not report any clinical improvement.At the same time,the VAS analysis showed a significant reduction in typical GERD symptoms after PPI therapy(P < 0.001).A significant reduction in LPS symptoms.On the other hand,such result was not recorded for LPS.Esophagitis was detected in 2/41 patients,and ineffective esophageal motility was found in 3/41 patients.The MII-pH analysis showed an abnormal AET in 5/41 patients(2 ERD and 3 NERD);11/41 patients had a normal AET and a positive association between symptoms and refluxes(HE),and 25/41 patients had a normal AET and a negative association between symptoms and refluxes(no GERD patients).It is noteworthy that HE patients had a positive association with typical GERD-related symptoms.Gas refluxes were found more frequently in patients with globus(29.7 ± 3.6) and hoarseness(21.5 ± 7.4) than in patients with heartburn or regurgitation(7.8 ± 6.2).Gas refluxes were positively associated with extraesophageal symptoms(P < 0.05).Overall,no differences were found among the three groups of patients in terms of the frequency of laryngeal signs.The proximal reflux was abnormal in patients with ERD/NERD only.The differences observed by means of MII-pH analysis among the three subgroups of patients(ERD/NERD,HE,no GERD) were not demonstrated with the RSI and RFS.Moreover,only the number of gas refluxes was found to have a significant association with the RFS(P = 0.028 andP = 0.026,nominal and numerical correlation,respectively).CONCLUSION:MII-pH analysis confirmed GERD diagnosis in less than 40% of patients with previous diagnosis of LPR,most likely because of the low specificity of the laryngoscopic findings.展开更多
The optimal control design for singularly perturbed time-delay systems affected by external distur-bances is considered.Based on the decomposition theory of singular perturbation,the system is decom-posed into a fast ...The optimal control design for singularly perturbed time-delay systems affected by external distur-bances is considered.Based on the decomposition theory of singular perturbation,the system is decom-posed into a fast subsystem without time-delay and a slow time-delay subsystem with disturbances.Theoptimal disturbances rejection control law of the slow subsystem is obtained by using the successive ap-proximation approach(SAA)and feedforward compensation method.Further,the feedforward and feed-back composite control(FFCC)law for the original problem is developed.The FFCC law consists of lin-ear analytic terms and a time-delay compensation term which is the limit of the solution sequence of theadjoint vector equations.A disturbance observer is introduced to make the FFCC law physically realiz-able.Numerical examples show that the proposed algorithm is effective.展开更多
Lateral inhibitory effect is a well-known feature of information processing in neural systems.This paper presents a neural array model with simple lateral inhibitory connections.After detailed examining into the dynam...Lateral inhibitory effect is a well-known feature of information processing in neural systems.This paper presents a neural array model with simple lateral inhibitory connections.After detailed examining into the dynamics of this kind of neural array,the author gives the sufficient conditions under which the outputs of the network will tend to a special stable pattern called spatial sparse pattern in which if the output of a neuron is 1,then the outputs of the neurons in its neighborhood are 0.This ability called spatial sparse coding plays an important role in self-coding,self-organization and associative memory for patterns and pattern sequences.The main conclusions about the dynamics of this kind of neural array which is related to spatial sparse coding are introduced.展开更多
基金The project supported by the National Fundamental Research Program under Grant No.2006CB921106National Natural Science Foundation of China under Grant Nos.10325521,60433050,and 60635040+1 种基金the SRFDP Program of Education Ministry of China under Grant No.20060003048the Key Project of the Ministry of Education of China under Grant No.306020
文摘In this paper, we present the decoupling bang-bang （BB） twin-born pulses to suppress the genera/deco- herence, both amplitude and phase decoherence, in a three-level atom in V- and Ξ-configurations. We give the exact sequence of periodic twinborn pulses in such systems.
文摘AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors(PPIs) for at least 8 wk,and the therapeutic outcome was assessed through validated questionnaires(GERD impact scale,GIS;visual analogue scale,VAS).LPR diagnosis was performed by ear,nose and throat specialists using the reflux finding score(RFS) and reflux symptom index(RSI).After a 16-d wash-out from PPIs,all patients underwent an upper endoscopy,stationary esophageal manometry,24-h multichannel intraluminal impedance and pH(MII-pH) esophageal monitoring.A positive correlation between LPR diagnosis and GERD was supposed based on the presence of esophagitis(ERD),pathological acid exposure time(AET) in the absence of esophageal erosions(NERD),and a positive correlation between symptoms and refluxes(hypersensitive esophagus,HE).RESULTS:The male/female ratio was 0.52(14/27),the mean age ± SD was 51.5 ± 12.7 years,and the mean body mass index was 25.7 ± 3.4 kg/m 2.All subjects reported one or more LPS.Twenty-five out of 41 patients also had typical GERD symptoms(heartburn and/or regurgitation).The most frequent laryngoscopic findings were posterior laryngeal hyperemia(38/41),linear indentation in the medial edge of the vocal fold(31/41),vocal fold nodules(6/41) and diffuse infraglottic oedema(25/41).The GIS analysis showed that 10/41 patients reported symptom relief with PPI therapy(P < 0.05);conversely,23/41 did not report any clinical improvement.At the same time,the VAS analysis showed a significant reduction in typical GERD symptoms after PPI therapy(P < 0.001).A significant reduction in LPS symptoms.On the other hand,such result was not recorded for LPS.Esophagitis was detected in 2/41 patients,and ineffective esophageal motility was found in 3/41 patients.The MII-pH analysis showed an abnormal AET in 5/41 patients(2 ERD and 3 NERD);11/41 patients had a normal AET and a positive association between symptoms and refluxes(HE),and 25/41 patients had a normal AET and a negative association between symptoms and refluxes(no GERD patients).It is noteworthy that HE patients had a positive association with typical GERD-related symptoms.Gas refluxes were found more frequently in patients with globus(29.7 ± 3.6) and hoarseness(21.5 ± 7.4) than in patients with heartburn or regurgitation(7.8 ± 6.2).Gas refluxes were positively associated with extraesophageal symptoms(P < 0.05).Overall,no differences were found among the three groups of patients in terms of the frequency of laryngeal signs.The proximal reflux was abnormal in patients with ERD/NERD only.The differences observed by means of MII-pH analysis among the three subgroups of patients(ERD/NERD,HE,no GERD) were not demonstrated with the RSI and RFS.Moreover,only the number of gas refluxes was found to have a significant association with the RFS(P = 0.028 andP = 0.026,nominal and numerical correlation,respectively).CONCLUSION:MII-pH analysis confirmed GERD diagnosis in less than 40% of patients with previous diagnosis of LPR,most likely because of the low specificity of the laryngoscopic findings.
基金the National Natural Science Foundation of China(No.60574023,40776051)the Natural Science Foundation of Zhejiang Province(No.Y107232)+1 种基金the Scientific Research Found of Zhejiang Provincial Education Department(No.Y200702660)the 123 Talent Funding Project of China Jiliang University(No.2006RC17)
文摘The optimal control design for singularly perturbed time-delay systems affected by external distur-bances is considered.Based on the decomposition theory of singular perturbation,the system is decom-posed into a fast subsystem without time-delay and a slow time-delay subsystem with disturbances.Theoptimal disturbances rejection control law of the slow subsystem is obtained by using the successive ap-proximation approach(SAA)and feedforward compensation method.Further,the feedforward and feed-back composite control(FFCC)law for the original problem is developed.The FFCC law consists of lin-ear analytic terms and a time-delay compensation term which is the limit of the solution sequence of theadjoint vector equations.A disturbance observer is introduced to make the FFCC law physically realiz-able.Numerical examples show that the proposed algorithm is effective.
文摘Lateral inhibitory effect is a well-known feature of information processing in neural systems.This paper presents a neural array model with simple lateral inhibitory connections.After detailed examining into the dynamics of this kind of neural array,the author gives the sufficient conditions under which the outputs of the network will tend to a special stable pattern called spatial sparse pattern in which if the output of a neuron is 1,then the outputs of the neurons in its neighborhood are 0.This ability called spatial sparse coding plays an important role in self-coding,self-organization and associative memory for patterns and pattern sequences.The main conclusions about the dynamics of this kind of neural array which is related to spatial sparse coding are introduced.
