With the continuous progress on affinity peptide research, it has become more and more popular in pharmacology and medicine. lt is promising to study these viruses affinity peptide to treat infectious diseases. And th...With the continuous progress on affinity peptide research, it has become more and more popular in pharmacology and medicine. lt is promising to study these viruses affinity peptide to treat infectious diseases. And the analysis on the virus affinity peptide with high selectivity and high sensitivity could provide valuable means for disease detection, treatment as wel as the study on the molecular mechanism of virus affinity peptide. Therefore, we reviewed the bioinformatics pre-diction technologies of computer simulation, molecular docking and homology model-ing, as wel as the research method on analyzing and screening virus affinity pep-tide, such as Phage display technology.展开更多
＂BIM （building information modeling）＂ and ＂sustainability＂ are two frequently used words in construction and academia today. BIM is a design-oriented tool, which generates a virtual three-dimensional model of a ...＂BIM （building information modeling）＂ and ＂sustainability＂ are two frequently used words in construction and academia today. BIM is a design-oriented tool, which generates a virtual three-dimensional model of a project. Sustainability refers to prudent use of earth＇s natural resources, and construction sustainability is the application of this principle to building activities. Societies in general and the construction industry in particular--one of the largest in terms of natural resources consumed and waste produced--place high hopes on BIM and the principles of sustainability to reduce consumption and waste and to increase industry productivity. BIM＇s capabilities and limitations, currently more focused on model creation and energy simulations, are not well understood as they relate to construction sustainability and its goals. No method yet exists to evaluate BIM＇s contribution comprehensively to construction sustainability goals. This study presents a construction sustainability goals contribution matrix for BIM. The matrix indicates that this contribution may be more limited than it is commonly thought.展开更多
As a pivotal signal pathway,the Ras/Raf/MEK/ERK cascade can be activated by multiple extracellular stimuli and can transmit signals to diverse substrates.It remains to be elucidated how so many different signals can b...As a pivotal signal pathway,the Ras/Raf/MEK/ERK cascade can be activated by multiple extracellular stimuli and can transmit signals to diverse substrates.It remains to be elucidated how so many different signals can be variously transferred by only two MEK molecules(MEK1 and MEK2) .Because of technological limitations the complete structures of the MEKs are still unavailable.Here,we report the full-length structure of MEK2 obtained by homology modeling and molecular dynamics simulations.The simulations show that the N-terminal part of MEK2 is highly flexible and this flexibility may enable MEK2 to interact with ERKs and other ligands in diverse manners that correspond to various upstream signals and downstream consequences.展开更多
Mining right asset securitization is a market financing pattern for mineral resources, and it is a creative application of financial asset securitization. Nowadays, because of world energy price decline, the world ene...Mining right asset securitization is a market financing pattern for mineral resources, and it is a creative application of financial asset securitization. Nowadays, because of world energy price decline, the world energy market is facing weak investment and financing sharply under pressure. Under this background, this paper aims at briefly commenting on the content, processes and impact of mining right asset securitization, understanding the international mining right asset securitization specific practices, and then combining the situation of China(Shanghai) Pilot Free Trade Zone so as to give advice for the development of mining right asset securitization in China. For instance, mineral mining rights and expenses system design are not clear, so the mineral values do not reflect their true costs and the need to speed up market credit system construction.展开更多
基金Supported by the Key Science and Technology Program of Henan Province(162102110136)the Science and Technology Fund for Outstanding Young People of Henan Academy of Agricultural Sciences(2016YQ28)~~
文摘With the continuous progress on affinity peptide research, it has become more and more popular in pharmacology and medicine. lt is promising to study these viruses affinity peptide to treat infectious diseases. And the analysis on the virus affinity peptide with high selectivity and high sensitivity could provide valuable means for disease detection, treatment as wel as the study on the molecular mechanism of virus affinity peptide. Therefore, we reviewed the bioinformatics pre-diction technologies of computer simulation, molecular docking and homology model-ing, as wel as the research method on analyzing and screening virus affinity pep-tide, such as Phage display technology.
文摘＂BIM （building information modeling）＂ and ＂sustainability＂ are two frequently used words in construction and academia today. BIM is a design-oriented tool, which generates a virtual three-dimensional model of a project. Sustainability refers to prudent use of earth＇s natural resources, and construction sustainability is the application of this principle to building activities. Societies in general and the construction industry in particular--one of the largest in terms of natural resources consumed and waste produced--place high hopes on BIM and the principles of sustainability to reduce consumption and waste and to increase industry productivity. BIM＇s capabilities and limitations, currently more focused on model creation and energy simulations, are not well understood as they relate to construction sustainability and its goals. No method yet exists to evaluate BIM＇s contribution comprehensively to construction sustainability goals. This study presents a construction sustainability goals contribution matrix for BIM. The matrix indicates that this contribution may be more limited than it is commonly thought.
基金supported by the National Natural Science Foundation of China(Grant No.30670791)the National Basic Research Program of China(Grant No.2009CB918301)+1 种基金the National High Technology Research and Development Program of China(Grant No.2008AA02Z124)the State Key Laboratory of Proteomics(Grant No.SKLP-Y200810)
文摘As a pivotal signal pathway,the Ras/Raf/MEK/ERK cascade can be activated by multiple extracellular stimuli and can transmit signals to diverse substrates.It remains to be elucidated how so many different signals can be variously transferred by only two MEK molecules(MEK1 and MEK2) .Because of technological limitations the complete structures of the MEKs are still unavailable.Here,we report the full-length structure of MEK2 obtained by homology modeling and molecular dynamics simulations.The simulations show that the N-terminal part of MEK2 is highly flexible and this flexibility may enable MEK2 to interact with ERKs and other ligands in diverse manners that correspond to various upstream signals and downstream consequences.
基金the Key Research Project of Shanxi Provincial Federation of Social Sciences(No.SSKLZDKT2014043)
文摘Mining right asset securitization is a market financing pattern for mineral resources, and it is a creative application of financial asset securitization. Nowadays, because of world energy price decline, the world energy market is facing weak investment and financing sharply under pressure. Under this background, this paper aims at briefly commenting on the content, processes and impact of mining right asset securitization, understanding the international mining right asset securitization specific practices, and then combining the situation of China(Shanghai) Pilot Free Trade Zone so as to give advice for the development of mining right asset securitization in China. For instance, mineral mining rights and expenses system design are not clear, so the mineral values do not reflect their true costs and the need to speed up market credit system construction.
